This review highlights advances in one-pot multicomponent synthesis of naphthyridine derivatives, focusing on efficient, atom-economical methods, diverse scaffolds and mechanistic insights fostering innovation in organic synthesis.
Our attempts to access these heteroatom-containing aromatic hexacycles are reported, as well as their photophysical properties, and ability to inhibit the activity of PIM 1 and 2 protein kinases.
From a quinolone library and subsequent medicinal chemistry optimization, we identified the fluoroquinolone 33, which demonstrated anti-ovarian cancer activity through a mechanism involving TRBP and resulting in the modulation of miRNA maturation.
In this investigation, we synthesized pyridonaphthyridines, as a new class of fused heterocyclic compounds, through an efficient multicomponent reaction.
Quinolino-azaullazines were prepared by combination of Pd catalyzed cross-coupling with Povarov and cycloisomerisation reactions. They show intramolecular charge transfer properties that can be tuned by the substitution pattern.