An efficient method is presented for the synthesis of chromeno[2,3-d]pyrimidine/chromeno[4,3-b]chromene derivatives via pTSA-catalyzed cyclization of 1,3-dimethylbarbituric acid/4-hydroxycoumarin, electron-rich arenes, and various salicylaldehydes.
Synthetic protocols access to complex dispiro[indene-2,3′-cyclopentane-1′,5′′-pyrimidines], dispiro[indoline-3,3′-cyclopentane-1′,5′′-pyrimidines] and spiro[cyclopenta[c]indeno[1,2-b]chromene-3,5′-pyrimidines] in good yields and with high diastereoselectivity was developed.
We demonstrate two distinct photomechanical responses (i.e. photomechanical bending and photosalient bursting) of two new 1,3-dimethylbarbituric acid derivative crystals based on tailoring their substituents and the modulation of their spacers.
Through this research, we have established an environmentally friendly and sustainable approach for the synthesis of spirobarbiturate (SB) derivatives, which hold significant potential in the field of medicinal chemistry.
CS-(M3SP)2-NH2·HSO4, was successfully utilized as a promoter in the synthesis of (±)-spiro[indoline-3,4′-pyrazolo[3,4-b]quinoline]dione and (±)-spiroindoline-pyrano[2,3-c]quinolone derivatives.