A one-pot, transition-metal-free, regioselective synthesis of spirooxindole derivatives containing benzimidazole-fused 1,4-benzoxazepine and benzosultam scaffolds has been developed.
Scandium triflate catalyzed synthesis of azo-fused benzothiazoloquinazolinones in ethanol via a multicomponent reaction. DFT and docking studies revealed strong interactions. In vitro assays showed cytotoxicity, suggesting anticancer potential.
Synthesis of 2-amino substituted benzo- and naphtho-furans via [4 + 1] cycloaddition of 2-hydroxy-substituted p-QMs and various alkyl/aryl isocyanides has been achieved by using Sc(OTf)3 as the catalyst.
Anti-proliferative evaluation and in silico validation of synthesized substituted-3-hydroxy-2-oxindoles.
This is the first example of the construction of harmaline-based spiropolycyclic scaffolds using harmaline-based N–C synthons and evaluation of 3cb as an anticancer agent.