This review aims to provide an overview of the biosyntheses of the striking azetidine-containing natural products, with an emphasis on the biosynthetic mechanisms of naturally occurring azetidines.
This study reports the design, synthesis, and biological evaluation of a novel series of 3-oxo-2,3-dihydropyridazine derivatives for selective inhibition of ITK, with potential application in T-cell leukemia treatment.
Electrophilic azetidinylation reagents enable efficient, “any-stage” installation of azetidine rings onto nucleophiles, providing modular access to 3,3-disubstituted azetidines for drug development.
Subjecting 2,2-disubstituted azetidines to amide coupling with carboxylic acids is found to effect either N-acylation or ring expansion to spiro- and 6,6-disubstituted 5,6-dihydro-4H-1,3-oxazines, dependent on the reaction conditions.
This paper presents a mild and efficient dual copper/photoredox-catalyzed multi-component allylation of azabicyclo[1.1.0]butanes using a radical-relay strategy.