The asymmetric catalytic synthesis of 1,2-diamines has received considerable interest, due to their presence in biologically active compounds and their applications for the development of synthetic building blocks, chiral ligands and organocatalysts.
Phosphazene base, P2-tBu, promoted the telescopic three-component reaction of diethyl phosphite, cinnamonitrile derivatives, and N-Boc imines, providing β-aminophosphonates having a tetrasubstituted carbon in a highly diastereoselective manner.
The distinctive structural features and broad synthetic utility of carbohydrates have established them as key scaffolds in asymmetric synthesis.
Asymmetric organocatalysis has acquired a prominent place in modern synthesis of noncanonical α-amino acids (ncAAs), valuable structural elements in organic synthesis, chemical biology, and medicine.
The advances in the Povarov reactions under visible-light conditions are highlighted, offering helpful guidance for selecting suitable synthetic protocols.