Recent advances in focal adhesion kinase (FAK)-targeting antitumor agents

Si-Kai Zhu, Qi Wu, Guang-Xin Liu, An-Qi Geng and Ping-An Wang

RSC Adv., 2025, 15, 20957
DOI: 10.1039/D5RA01880C

Easy access to 5-cyanotriazoles via Pd-catalyzed cyanation of 5-iodotriazoles

Rostislav N. Galashev, Gennadij V. Latyshev, Yury N. Kotovshchikov, Nikolay V. Lukashev and Irina P. Beletskaya

Org. Biomol. Chem., 2025, 23, 4725
DOI: 10.1039/D5OB00356C

Nitrile biosynthesis in nature: how and why?

Mingyu Liu and Shengying Li

Nat. Prod. Rep., 2024, 41, 649
DOI: 10.1039/D3NP00028A

A transition metal-free [3 + 2] cycloaddition approach for the efficient synthesis of trisubstituted pyrrole derivatives from β-chlorovinyl aldehydes

Jyoti, Vaishali, Shreya Sharma, Diptangshu P. Borthakur, Deepika, Chandi C. Malakar and Virender Singh

Org. Biomol. Chem., 2025, 23, 4735
DOI: 10.1039/D5OB00351B

Solvent-controlled silver catalyzed radical transformation of α-imino-oxy acids with cyclic aldimines

Jingjing Wang, Yuran Qin, Ke Cui, Xueqi Li, Mingyue Cui, Sheng Cao, Linbo Zhang, Qin Shen, Teng Wang and Feng Li

Chem. Commun., 2025, 61, 3359
DOI: 10.1039/D4CC05675B

Photoredox/Cu dual catalyzed 1,4-cyanosulfonylation enabled by remote cyano migration

Xiaofei Xie, Yan Li, Zhengyuan Bo, Yingguang Zhu and Kang Chen

Org. Chem. Front., 2024, 11, 4857
DOI: 10.1039/D4QO00827H

Bacterial Biosynthesis of Nitrile-Containing Natural Products: Basis for Recognition of Diversified Substrates

Ming Peng, Qiaoling Wu, Lele Ma, Zhao-Jie Teng, Xuben Hou, Hongjie Zhu and Jianhua Ju

ACS Catal., 2024, 14, 17780
DOI: 10.1021/acscatal.4c06581

Biocompatible Synthesis of Macrocyclic Thiazol(in)e Peptides

Junming He and Christoph Nitsche

Chemistry A European J, 2024, 30
DOI: 10.1002/chem.202401716

Advances in the Search for SARS-CoV-2 Mpro and PLpro Inhibitors

Marcel Arruda Diogo, Augusto Gomes Teixeira Cabral and Renata Barbosa de Oliveira

Pathogens, 2024, 13, 825
DOI: 10.3390/pathogens13100825

Silver-Catalyzed Difluorocarbene Activation Enables Multicomponent Synthesis of δ,γ-Unsaturated β-Hydroxynitriles

Tong Zhou, Yu Chen, Xu Yuan, Qiaoqiao Wang, Mingquan Yuan, Jianwu Tian and Yi Jin

J. Org. Chem., 2025, 90, 12734
DOI: 10.1021/acs.joc.5c01578

Covalent Inhibitors - An Overview of Design Process, Challenges and Future Directions

Simon Mugisa and Manikanta Murahari

COC, 2025, 29, 1424
DOI: 10.2174/0113852728361926250123092017

Regioselective Hydrocyanation of Internal Alkynes Enabled by a Transition‐Metal‐Free Dual‐Catalytic System

Aleksandra Zasada and Dawid Lichosyt

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202500940

JAK3 Inhibitors: Covalent and Noncovalent Interactions of a Cyanamide Group Investigated by Multiscale Free-Energy Simulations

Laura Scalvini, Daniele Pala, Alberto Cuzzolin, Francesca Galvani, Alessio Lodola, Silvia Rivara, Marco Mor and Andrea Rizzi

J. Chem. Inf. Model., 2025, 65, 1404
DOI: 10.1021/acs.jcim.4c01889

Nirmatrelvir: From Discovery to Modern and Alternative Synthetic Approaches

Michela Galli, Francesco Migliano, Valerio Fasano, Alessandra Silvani, Daniele Passarella and Andrea Citarella

Processes, 2024, 12, 1242
DOI: 10.3390/pr12061242

Dipeptide-Derived Alkynes as Potent and Selective Irreversible Inhibitors of Cysteine Cathepsins

Lydia Behring, Gloria Ruiz-Gómez, Christian Trapp, Maryann Morales, Robert Wodtke, Martin Köckerling, Klaus Kopka, M. Teresa Pisabarro, Jens Pietzsch and Reik Löser

J. Med. Chem., 2023, 66, 3818
DOI: 10.1021/acs.jmedchem.2c01360

Identification of nitrile-containing isoquinoline-related natural product derivatives as coronavirus entry inhibitors in silico and in vitro

Nasim Shahhamzehei, Sara Abdelfatah, Hannah S. Schwarzer-Sperber, Kathrin Sutter, Rümeysa Yücer, Gerhard Bringmann, Roland Schwarzer and Thomas Efferth

Biomedicine & Pharmacotherapy, 2024, 180, 117517
DOI: 10.1016/j.biopha.2024.117517

Chiral Discrimination of Nitrile Compounds Using a 19F-Labeled Palladium Probe

Guangxing Gu, Yue Yue, Chenyang Wang, Wei Zhang, Jian Wu, Ya Li and Yanchuan Zhao

Org. Lett., 2023, 25, 4819
DOI: 10.1021/acs.orglett.3c01525

Divergent Regioselective Synthesis of Functionalized 1,2,3‐1H‐Triazoles from Nitriles and Arylazides Under Metal‐Free and/or Solvent‐Free Conditions

Fernanda Petzold Pauli, Edson de Oliveira Lima Filho, Gerlon de Almeida Ribeiro Oliveira, Luciano Morais Lião, Vinicius Rangel Campos, Luana da Silva Magalhães Forezi, Vitor Francisco Ferreira and Fernando de Carvalho da Silva

Chemistry An Asian Journal, 2024, 19
DOI: 10.1002/asia.202400845

Potent and Selective Human 5-HT2B Serotonin Receptor Antagonists: 4′-Cyano-(N)-methanocarba-adenosines by Synthetic Serendipity

Dilip K. Tosh, Matteo Pavan, Allison A. Clark, Josie Lammers, Serafina Villano, Silvia Marri, Silvia Sgambellone, Suebin Choi, Jihyun Lee, Marko S. Ivancich, Hailey A. Bock, Ryan G. Campbell, Sarah A. Lewicki, Ian M. Levitan, Eric Chen, Naili Liu, Tamar Demby, Oksana Gavrilova, Zhan-Guo Gao, Laura Lucarini, John D. McCorvy and Kenneth A. Jacobson

J. Med. Chem., 2024, 67, 21264
DOI: 10.1021/acs.jmedchem.4c02174

Asymmetric Synthesis of Chiral Aliphatic α‐Tertiary Aminonitriles via Organocatalytic Isomerization of Cyanoketimines

Ling Xu, Jisheng Luo and Li Deng

Chin. J. Chem., 2024, 42, 3387
DOI: 10.1002/cjoc.202400774

Divergent Radical, Dimerization, and Carbene Formation from One‐Electron Reduction of 2‐Cyanoimidazolium Salts

Jawon Jang, Jaelim Kim and Eunsung Lee

Asian J Org Chem, 2025, 14
DOI: 10.1002/ajoc.202500443

Exploring the Chiral Match–Mismatch Effect in the Chiral Discrimination of Nitriles

Guangxing Gu, Yining Sun, Chenyang Wang, Yilin Zeng, Tianci Peng, Byungjin Koo and Yanchuan Zhao

Anal. Chem., 2025, 97, 1909
DOI: 10.1021/acs.analchem.4c06117

Regioselective Synthesis of Isonitrile-Containing Densely Functionalized Alkenes from Propynenitriles

Jyoti Jyoti, Rahul Jamra, Deepika Deepika, Shreya Sharma, Chandi C. Malakar and Virender Singh

Synlett, 2025, 36, 2304
DOI: 10.1055/a-2538-1363

Novel selective proline-based peptidomimetics for human cathepsin K inhibition

Felipe Cardoso Prado Martins, Fernanda dos Reis Rocho, Vinícius Bonatto, Pedro Henrique Jatai Batista, Jerônimo Lameira, Andrei Leitão and Carlos A. Montanari

Bioorganic & Medicinal Chemistry Letters, 2024, 110, 129887
DOI: 10.1016/j.bmcl.2024.129887

Sono‐And Mechanochemistry‐Assisted Dual Strategies for Cyanomethylation of Carboxylic Acids: Robust and Practical Synthetic Protocols to a Diverse Series of Cyanomethyl Esters

Pintu Karmakar and Goutam Brahmachari

Chemistry A European J, 2025
DOI: 10.1002/chem.202501966

Recent advances in asymmetric [2+1] cycloaddition with α-cyano diazo compounds

Shuicai Chen, Qiuzhan Huang, Xiaoyu Ren, Zhen Guo, Chengming Wang and Cong-Ying Zhou

Tetrahedron Chem, 2025, 15, 100137
DOI: 10.1016/j.tchem.2025.100137

A Comprehensive Review of Radical-Mediated Intramolecular Cyano-Group Migration

Jia-Liang Zhu and Mei-Lin Chen

Molecules, 2025, 30, 2959
DOI: 10.3390/molecules30142959

Diversity oriented synthesis of cyano-substituted polycyclic N-heteroaryl compounds in green solvent

Yuan-Qi Li, Zhi-Jie Kang, Ben-Jun Han, Yan-Chun Zhang, Fan Teng and Cheng-Tao Feng

Sustainable Chemistry and Pharmacy, 2025, 46, 102114
DOI: 10.1016/j.scp.2025.102114

The Nitrile Bis-Thiol Bioconjugation Reaction

Mikesh Patel, Nafsika Forte, Charlie R. Bishop, Michael J. Porter, Matthew Dagwell, Kersti Karu, Vijay Chudasama and James R. Baker

J. Am. Chem. Soc., 2024, 146, 274
DOI: 10.1021/jacs.3c08762

Organophotocatalytic Three‐Component Assembly of C4‐Cyanoalkylated Phthalazin‐1(2H)‐Ones

Poornima Mishra, Ruchir Kant and Namrata Rastogi

Chemistry An Asian Journal, 2025, 20
DOI: 10.1002/asia.202401931

Covalent small-molecule inhibitors of SARS-CoV-2 Mpro: Insights into their design, classification, biological activity, and binding interactions

Ahmed M. Shawky, Faisal A. Almalki, Hayat Ali Alzahrani, Ashraf N. Abdalla, Bahaa G.M. Youssif, Nashwa A. Ibrahim, Mohammed Gamal, Hany A.M. El-Sherief, Maha M. Abdel-Fattah, Ahmed A. Hefny, Ahmed H. Abdelazeem and Ahmed M. Gouda

European Journal of Medicinal Chemistry, 2024, 277, 116704
DOI: 10.1016/j.ejmech.2024.116704

Design and Synthesis of Barbiturates and Hydantoins with Multitarget Antidiabetic Effect☆

Samantha Juárez-Cruz, Samuel Estrada-Soto, Blanca Colin-Lozano, Hugo Marquina-Rodriguez, Thalía Delgado-Aguilar, Carlos Martínez-Conde, Abraham Gutiérrez-Hernández, Emanuel Hernández-Núñez, Abraham Giacoman-Martínez, Julio Cesar Almanza-Pérez and Gabriel Navarrete-Vazquez

J. Mex. Chem. Soc., 2024, 68, 609
DOI: 10.29356/jmcs.v68i4.2284

Potent α-glucosidase inhibitors with benzimidazole-propionitrile hybridization; synthesis, bioassay and docking study

Ebrahim Saeedian Moghadam, Abdullah Mohammed Al-Sadi, Mahdis Sadeghi Moghadam, Bahareh Bayati, Somayeh Mojtabavi, Mohammad Ali Faramarzi, Mohsen Amini and Raid Abdel-Jalil

Future Medicinal Chemistry, 2024, 16, 2395
DOI: 10.1080/17568919.2024.2401314

Synthesis, crystal structure, and DFT of ( R )-2-(8-hydroxy-1,6,7,8-tetrahydro-2 H -indeno[5,4-b]furan-8-yl) acetonitrile

Jin-Lan Li, Yuan Shi, Li-Xue Ma, Zhi-Xu Zhou and Chun Ji

Molecular Crystals and Liquid Crystals, 2023, 765, 1
DOI: 10.1080/15421406.2023.2206714

Titanium-promoted conversion of N2 into N-methylimides

Rui Hu, Yidan Qi, Xingyu Wang, Yunhui Yang and Congyang Wang

Chinese Chemical Letters, 2025, 111197
DOI: 10.1016/j.cclet.2025.111197

Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update

Laura Hillebrand, Xiaojun Julia Liang, Ricardo A. M. Serafim and Matthias Gehringer

J. Med. Chem., 2024, 67, 7668
DOI: 10.1021/acs.jmedchem.3c01825

Tandem, Catalyst‐Free C−C Synthesis of Nitriles from Aldehydes and Methyl Cyanoacetate with Sodium Hypophosphite

Vasily Korochantsev, Artemy Fatkulin, Evgeniya Podyacheva, Alexander Boldyrev, Oleg I. Afanasyev and Denis Chusov

Eur J Org Chem, 2025, 28
DOI: 10.1002/ejoc.202401108

Recent Advances on Targeting Proteases for Antiviral Development

Pedro Henrique Oliveira Borges, Sabrina Baptista Ferreira and Floriano Paes Silva

Viruses, 2024, 16, 366
DOI: 10.3390/v16030366

Differential specificity of SARS‐CoV‐2 main protease variants on peptide versus protein‐based substrates

Fernanda R. Rocho, Scott J. Snipas, Anwar Shamim, Wioletta Rut, Marcin Drag, Carlos A. Montanari and Guy S. Salvesen

The FEBS Journal, 2024, 291, 61
DOI: 10.1111/febs.16970

Recent Developments of Transition‐Metal‐Catalyzed Cross‐Coupling of Nitriles and Alcohols

Xiuju Cai, Xurui Wei and Ming Huang

ChemistrySelect, 2024, 9
DOI: 10.1002/slct.202402955

Classifying covalent protein binders by their targeted binding site

Walaa A. Bedewy, John W. Mulawka and Marc J. Adler

Bioorganic & Medicinal Chemistry Letters, 2025, 117, 130067
DOI: 10.1016/j.bmcl.2024.130067

Regioselective Hydrocyanation of Internal Alkynes Enabled by a Transition‐Metal‐Free Dual‐Catalytic System

Aleksandra Zasada and Dawid Lichosyt

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202500940

Substituted meta[n]Cycloparaphenylenes: Synthesis, Photophysical Properties and Host–guest Chemistry

Felix Bernt and Hermann A. Wegner

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202301001

Discovery of new covalent inhibitors of monoacylglycerol lipase with the nitrile warhead via SCARdock

Juanping Wang, Xiaoyu Shi, Junlai Wang, Qiang Zheng, Peipei Shao and Sen Liu

Bioorganic Chemistry, 2025, 159, 108378
DOI: 10.1016/j.bioorg.2025.108378

Evaluating the protonation state of the catalytic Cys25 in cruzain cysteine protease: A target for Chagas disease

Clauber H. S. da Costa, Vinícius Bonatto, Hemillin Brenda Teixeira Santos, Carlos Gabriel da Silva de Souza, Carlos A. Montanari, Munir S. Skaf, F. Javier Luque and Jerônimo Lameira

Protein Science, 2025, 34
DOI: 10.1002/pro.70283

Structural and Mechanistic Basis for Nitrile Synthetase by an Argininosuccinate Synthetase-Like Enzyme

Yujing Zeng, Keke Zhang, Tiantian Lu, Xinjian Yin, Qiang Wang, Longwei Xiong, Heng Guo, Jing Li, Xuefeng Lu, Lan Liu, Honglei Ma and Zhizeng Gao

ACS Catal., 2025, 16254
DOI: 10.1021/acscatal.5c04243

Electrochemical demethoxyl-cyanation of methoxyarenes via SNAr

Shuai Chen, Anzai Shi, Guoqing Yang, Pengfei Xie, Feng Liu and Youai Qiu

Chinese Chemical Letters, 2025, 36, 110810
DOI: 10.1016/j.cclet.2024.110810

Specificity and breadth of plant specialized metabolite–microbe interactions

Daniel J. Kliebenstein

Current Opinion in Plant Biology, 2024, 77, 102459
DOI: 10.1016/j.pbi.2023.102459

Correlating Predicted Reactivities with Experimental Inhibition Data of Covalent ChlaDUB1 Inhibitors

Thomas Zimmermann, Erik Endres, Christoph Sotriffer and Michael Decker

ACS Med. Chem. Lett., 2024, 15, 1708
DOI: 10.1021/acsmedchemlett.4c00267

Palladium-catalyzed enantioselective [2σ + 2π] cycloadditions of vinyl-carbonyl-bicyclo[1.1.0]butanes with arylidenemalononitriles

Tianzhu Qin and Weiwei Zi

Chinese Chemical Letters, 2025, 111072
DOI: 10.1016/j.cclet.2025.111072

Structure-property Relationships Reported for the New Drugs Approved in 2022

Kihang Choi

MRMC, 2024, 24, 330
DOI: 10.2174/1389557523666230519162803

Landscape of In Silico Tools for Modeling Covalent Modification of Proteins: A Review on Computational Covalent Drug Discovery

Md Nazmul Hasan, Manisha Ray and Arjun Saha

J. Phys. Chem. B, 2023, 127, 9663
DOI: 10.1021/acs.jpcb.3c04710

tert-BuONO-Promoted Nitrosation of 4-Nitroisoxazole-Based Enamines: Synthesis of 5-Cyanoisoxazoles and Their Application

Nadezhda E. Astakhova, Dmitry A. Vasilenko, Maria S. Kuzmina, Aleksandr K. Pupeza, Yuri K. Grishin, Victor A. Tafeenko and Elena B. Averina

J. Org. Chem., 2025, 90, 12138
DOI: 10.1021/acs.joc.5c01207

Novel cyanide-containing porphyrins: Unleashing in vitro photodynamic therapy potential

Wen-Yuan Zhang, Gui-Chen Li, Dong-Le Tian, Bo Wang, Yan Fan, Xue-Qin Sun, Xiao-Gang Yang, Chun-Yan Zhang, Xiao-Xia Feng, Wei-Bing Xu and Jia-Cheng Liu

Journal of Molecular Structure, 2025, 1322, 140487
DOI: 10.1016/j.molstruc.2024.140487