Research progress on drug delivery systems based on traditional chinese medicine polysaccharides for the treatment of colon cancer

Liu Yu Rong, Zhan Yu, Liu Jing, Sun Chao and Tang Xue Gui

J. Mater. Chem. B, 2026, 14, 1494
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Resistant starch and tannic acid synergistically ameliorated dextran sulfate sodium-induced ulcerative colitis, particularly in the distal colon

Zijun Liu, Shunjing Luo, Chengmei Liu and Xiuting Hu

Food Funct., 2024, 15, 7553
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Extraction and Structural Characterization of Four Grape Polysaccharides and Their Protective Effects in Alcohol-Induced Gastric Mucosal Injury

Jian Shao, Jizhen Li, Yonghui Zhao, Rong Huang, Aixin Guo, Lijuan Hou, Xiangpeng Leng and Qiu Li

Foods, 2024, 13, 3500
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A polysaccharide isolated from sea cucumber intestines enhances immunity and modulates gut microbiota and metabolism with efficacy comparable to that from the body wall

Xinyi Jin, Lin Bai, Chen Song, Jingjing Li, Xiaomeng Ren, Fanhua Kong, Chunqing Ai and Shuang Song

Food Bioscience, 2026, 75, 108084
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Phenolics‐Rich Extract from Agarwood Leaf‐Tea Alleviate Dextran Sulfate Sodium (DSS)‐Induced Ulcerative Colitis Via Modulating Intestinal Barrier Function, Liver Inflammation, and Gut Microbiota

Ruyan Fan, Wensong Wei, Youjing Wei, Xue Lin, Shaobo Zhou and Lu Wang

Molecular Nutrition Food Res, 2024, 68
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Evaluation of the Relative Ordered Structure of Polysaccharide: a case study on polysaccharide characterization from Gymnadenia conopsea

Junqiao Wang, Chengxi Feng, Hui Yan, Zhe Wang, Yajie Wang, Junyi Yin and Shaoping Nie

Bioactive Carbohydrates and Dietary Fibre, 2026, 35, 100519
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A synbiotic combination of arabinogalactan and Bacteroides thetaiotaomicron ameliorates ulcerative colitis in mice

Shanshan Zhang, Yonggan Sun, Yuhao Li, Chunhua Chen and Shaoping Nie

Food Research International, 2026, 230, 118617
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Effects of Hydrolysis Condition and Detection Method on the Monosaccharide Composition Analysis of Polysaccharides from Natural Sources

Meijuan Zhao, Fengyan Kuang, Yingyue Zhang and Guangping Lv

Separations, 2023, 11, 2
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Okra Flower Polysaccharides Ameliorate Dextran Sulfate Sodium-Induced Ulcerative Colitis by Modulating ABC Transporters Via the Gut Microbiota

Yuanle Deng, Ziqiao Zhao, Xiangfu Gu, Liqun Wang, Yujie Zhang, Xiaoyi Huang, Xingjie Li, Xudan Lei, Zhujuan Xiong, Fusheng Zhang and Yongxia Zhu

J. Agric. Food Chem., 2026, 74, 10249
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Benefits and mechanisms of polysaccharides derived from traditional Chinese medicine for ulcerative colitis treatment (Review)

Yuebo Jia, Zheng Jiao, Lingshuo Bai, Gege Li and Lijian Pang

Exp Ther Med, 2026, 32, 1
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Auricularia auricula’s Exopolysaccharide Mitigates DSS-Induced Colitis Through Dectin–1-Mediated Immunomodulation and Microbiota Remodeling

Luísa Coutinho Coelho, Luísa Dan Favilla, Thais Bergmann de Castro, Maria Carolina B. Di Medeiros Leal, Christian Hoffmann and Anamélia Lorenzetti Bocca

Pharmaceuticals, 2025, 18, 1085
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Cordyceps Sinensis Reduces Inflammation and Protects BEAS-2B Cells From LPS-Induced THP-1 Cell Injury

Xiaqing Wu, Xin Li, Ying Chai, Yushan Tian, Hongjuan Wang, Xiao Li, Jingzheng Zhang, Chunmei Guang, Enliang Hong, Haoping Cheng, Qingyuan Hu, Huan Chen and Hongwei Hou

JIR, 2025, Volume 18, 4143
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Cordycepin inhibits kidney injury by regulating GSK‐3β‐mediated Nrf2 activation

Zhiling Tang, Kean Chen, Chun Sun, Xiangjun Ying and Ming Li

J Biochem & Molecular Tox, 2024, 38
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Luteolin modulates macrophage phenotypic switching via the AMPK-PPARγ pathway to alleviate ulcerative colitis in mice

Shuai Yang, Hongwei Duan, Jianlin Zeng, Zhenxing Yan, Tian Niu, Xiaofei Ma, Yong Zhang, Junjie Hu, Lihong Zhang and Xingxu Zhao

Journal of Ethnopharmacology, 2025, 339, 119157
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Bioactive Polysaccharides Prevent Lipopolysaccharide-Induced Intestinal Inflammation via Immunomodulation, Antioxidant Activity, and Microbiota Regulation

Mingyang Gao, Wanqing Zhang, Yan Ma, Tingting Liu, Sijia Wang, Shuaihu Chen, Zhengli Wang and Hong Shen

Foods, 2025, 14, 2575
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The ethanolic extract of domesticated Amauroderma rugosum alleviated DSS-induced ulcerative colitis via repairing the intestinal barrier

Jianyuan Kang, Weicang Xie, Lingping Wu, Yuanyuan Liu, Youcai Xu, Yifei Xu, Yanzhen Mai, Lisheng Peng, Bin Huang, Shaoju Guo and Shuang Luo

Food Sci Biotechnol, 2024, 33, 3335
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Bitter Melon Polysaccharides Enhance Goblet Cell Function and Mucosal Integrity in DSS‐Induced Colitis Through Microbiota Remodeling

Tangying Kang, Yiming Zhu, Jiaxuan Zhu, Meiling Xiao, Yansheng Zhao, Ying Zhu and Xiang Xiao

Food Bioengineering, 2026, 5, 30
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Agrocybe cylindracea Polysaccharides Ameliorate DSS-Induced Colitis by Restoring Intestinal Barrier Function and Reprogramming Immune Homeostasis via the Gut–Liver Axis

Aamna Atta, Muhammad Naveed, Mujeeb Ur Rahman, Yamina Alioui, Immad Ansari, Sharafat Ali, Eslam Ghaleb, Nabeel Ahmed Farooqui, Mohammad Abusidu, Yi Xin and Bin Feng

IJMS, 2025, 26, 6805
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Protective bioactivity of Ziziphus jujuba dates polysaccharide on colitis via improving the intestinal barrier and modifying the gut microbiota

Qiaoying Song and Xinyong You

Carbohydrate Polymer Technologies and Applications, 2025, 11, 100931
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Phenolamide Extract of Apricot Bee Pollen Alleviates DSS-Induced Ulcerative Colitis in Mice by Reducing Oxidative Stress, Modulating Inflammation, and Regulating Gut Microbiota

Wei Liu, Rui Liu, Yihang Han, Xin Chen and Qun Lu

Antioxidants, 2026, 15, 403
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The effects of Cordyceps polysaccharides on ischemic brain injury in rats via intervening with IL-23/IL-17 axis and the intestinal barrier

Yang Jiang, Yan Liao, Zhenquan Liu, Manyu Zhou, Huizhang Wang, Huiming Qi, Shuyong Sun, Saiwen Xi and Yibo Tang

International Journal of Biological Macromolecules, 2024, 283, 137526
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Cordyceps sinensis polysaccharide disrupts the macrophage pyroptosis-neutrophil extracellular traps axis to ameliorate acute lung injury

Jingwen Xu, Sihan Chen, Shushu Xie, Fangmei Zhou, Mingyuan Zhou, Xiaoqing Ye, Bingqi Zhu, Zhishan Ding and Yuchi Chen

Journal of Ethnopharmacology, 2026, 122063
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A Systematic Review on the Research Progress on Polysaccharides from Fungal Traditional Chinese Medicine

Chenxi Bai, Fazhi Su, Wensen Zhang and Haixue Kuang

Molecules, 2023, 28, 6816
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Molecular Mechanisms of Polysaccharides in Regulating Immune Function and Treating Rheumatoid Arthritis Through Modulation of Gut Microbiota

Kunqin Huang, Jianlei Xie and Fang Zhang

Immunological Investigations, 2026, 1
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Immune cell-targeted nanocarrier delivery systems for inflammatory bowel disease therapy: mechanisms and strategies

Yuying Tang, Zijian Wu, Hui Zhao, Wenjing Liang, Ao Qu, Runyan Wang, Shuaishuai Gao, Pei Zhao, Jiali Liu, Zhizhe Zhang, Xuemei Han, Wu Liang and Wen Zhang

International Journal of Pharmaceutics, 2026, 698, 126963
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Luteolin ameliorates DSS-induced colitis in mice via suppressing macrophage activation and chemotaxis

Liwei Xue, Xiaosheng Jin, Tingting Ji, Rongzhou Li, Xiaoju Zhuge, Fang Xu, Zijiao Quan, Haibin Tong and Weilai Yu

International Immunopharmacology, 2023, 124, 110996
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Early life stress induces irritable bowel syndrome from childhood to adulthood in mice

Enfu Tao, Yuhao Wu, Chenmin Hu, Zhenya Zhu, Diya Ye, Gao Long, Bo Chen, Rui Guo, Xiaoli Shu, Wei Zheng, Ting Zhang, Xinyi Jia, Xiao Du, Marong Fang and Mizu Jiang

Front. Microbiol., 2023, 14
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Quantitative Proteomics Analysis Insights into the Cordyceps Polysaccharides Biosynthesis

Chunhua Xu, Yifan Guo, Xiaoni Chen, Xi Liu, Zhiyuan Li and Shan Lin

Appl Biochem Biotechnol, 2026, 198, 1899
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Potential interventions and interactions of bioactive polyphenols and functional polysaccharides to alleviate inflammatory bowel disease – A review

Muhammad Salman Farid, Bakhtawar Shafique, Rui Xu, Łukasz Łopusiewicz and Changhui Zhao

Food Chemistry, 2025, 462, 140951
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Polysaccharide from natural Ophiocordyceps sinensis alleviated dextran sulfate sodium-induced colitis through modulating sIgA formation and gut microbiota

Shuping Chen, Junqiao Wang, Qiuyue Fang, Nan Dong, Steve W. Cui and Shaoping Nie

Journal of Functional Foods, 2025, 131, 106921
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Hirsutella sinensis fungus Alleviates Ulcerative Colitis via Modulating Gut microbiota-derived Ursodeoxycholic Acid Biosynthesis to Inhibit Th17 Cell Differentiation

Jie Fu, Jianglin Chen, Guofu Feng, Saifei Xi, Xianli Liu, Qinghua Yao, Huiying Fu and Qiyang Shou

Journal of Future Foods, 2025
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Polysaccharides of Cistanche tubulosa (Schenk) R. Wight alleviate ulcerative colitis by modulating short-chain fatty acid production and the MAPK/NF-κB pathway through regulation of the gut microbiota

Shuyi Ji, Dongxuan Zheng, Yu Wang, Yawen Bai, Junjie Tan, XueMei Qin, Jun Yao and Jing Shen

International Immunopharmacology, 2026, 169, 116015
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The Large Molecular Weight Polysaccharide from Wild Cordyceps and Its Antitumor Activity on H22 Tumor-Bearing Mice

Li Tan, Sijing Liu, Xiaoxing Li, Jing He, Liying He, Yang Li, Caixia Yang, Yong Li, Yanan Hua and Jinlin Guo

Molecules, 2023, 28, 3351
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Nondestructive rapid identification of wild Cordyceps sinensis with portable instrument

Mengqi Zhang, Qin Li, Lei Nie, Ping Hai, Wei Zhang, Wangmao Caiji, Wenyan Liang, Hui Zhang and Hengchang Zang

Phytochemical Analysis, 2024, 35, 1540
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Anti-Inflammatory Mechanisms and Translational Relevance of Cordyceps sinensis and Its Bioactive Constituents

Jiahao Xie, Jingwen Xu, Qi Fan and Yuchi Chen

JIR, 2026, Volume 19, 1
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Research advancements and perspectives of inflammatory bowel disease: A comprehensive review

Junyi Bai, Ying Wang, Fuhao Li, Yueyao Wu, Jun Chen, Meng Li, Xi Wang and Bin Lv

Science Progress, 2024, 107
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Polygonatum cyrtonema polysaccharides reshape the gut microbiota to ameliorate dextran sodium sulfate-induced ulcerative colitis in mice

Chaoyou Lin, Dawei Song, Shangwen Wang, Yunfei Chu, Changxing Chi, Sining Jia, Mengyi Lin, Chenbei He, Chengxi Jiang, Fanghua Gong and Qiongzhen Chen

Front. Pharmacol., 2024, 15
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Recent progress in plant-derived polysaccharides with prebiotic potential for intestinal health by targeting gut microbiota: a review

Xiaozhen Wang, Xia Li, Luyao Zhang, Lingzhuo An, Lanping Guo, Luqi Huang and Wenyuan Gao

Critical Reviews in Food Science and Nutrition, 2024, 64, 12242
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Astragalus Polysaccharide Improved DSS‐Induced Colitis in Mice By Remodeling the Gut Microbiota

Israr Khan, Yanrui Bai, Junxiang Li, Ziyuan Wang, Zhiming Xu, Tao Yuan, Xiangyuan Liu, Yu Zhang, Chunjiang Zhang and Shu Xu

eFood, 2026, 7
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Polysaccharides from Black Mulberry Attenuate Colitis through Gut Microbiota Mediated TNF-α/pNF-κB/ICAM-1 Signaling Pathway

Li-Tao Yi, Xin-Yu Wang, Lin Zhou, Jie Cheng, Guang-Hui Xu and Ji-Xiao Zhu

J. Agric. Food Chem., 2025, 73, 14314
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Desulfovibrio in the Gut: The Enemy within?

Sudha B. Singh, Amanda Carroll-Portillo and Henry C. Lin

Microorganisms, 2023, 11, 1772
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Cordyceps cicadae polysaccharides ameliorate ulcerative colitis by modulating the gut microbiota and regulating the bile acid/FXR/NF-κB signaling pathway

Siyu Zhou, Fayu Su, Qinhan Gao, Majie Wang, Jialin Duan and Jiankang Li

Phytomedicine, 2026, 153, 158007
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