Onchidium struma polysaccharides exhibit hypoglycemic activity and modulate the gut microbiota in mice with type 2 diabetes mellitus

Yunfeng Zhao, Peilin Song, Shuai Yin, Tianyong Fan, Fengwei Li, Xiaodong Ge, Tingting Liu, Wei Xu, Su Xu and Ligen Chen

Food Funct., 2023, 14, 1937
DOI: 10.1039/D2FO02450K

Hypoglycemic potential of the extracts and active compounds from the aerial parts of Dioscorea opposita (Chinese yam)

Laibin Zhang, Xiaona Nie, Huihui Li, Shuangyan Guo and Jieli Lv

Journal of Functional Foods, 2025, 126, 106707
DOI: 10.1016/j.jff.2025.106707

Research Progress of Traditional Chinese Medicine in Adjuvant Treatment of Type 1 Diabetes

Jian Luo, Fuli Hu, Zhuolin Jia, Xiaoli Zhu, Ye Zhou, Changhe Hu, Lingying Yu and Zhimin Chen

Phytotherapy Research, 2025, 39, 5567
DOI: 10.1002/ptr.8514

Dietary oxygenated water mitigates type 2 diabetes mellitus by modulating gut microbiota and enhancing glucose metabolism in skeletal muscle

Yue Xiao, Dongmei Yang, Xiaoqing Chen, Li Xiong, Huan Guo, Sheng Ma, Bin Li, Hong Gao and Yina Huang

Food Bioscience, 2024, 62, 105110
DOI: 10.1016/j.fbio.2024.105110

Short-Clustered Maltodextrin Activates Ileal Glucose-Sensing and Induces Glucagon-like Peptide 1 Secretion to Ameliorate Glucose Homeostasis in Type 2 Diabetic Mice

Haocun Kong, Luxi Yu, Caiming Li, Xiaofeng Ban, Zhengbiao Gu and Zhaofeng Li

J. Agric. Food Chem., 2022, 70, 12604
DOI: 10.1021/acs.jafc.2c04978

Modulation of gut microbiota by crude mulberry polysaccharide attenuates knee osteoarthritis progression in rats

Yi-Zhou Zheng, Qing-Rou Chen, Hong-Mei Yang, Ji-Ao Zhao, Ling-Zhi Ren, Ye-Qun Wu, Yong-Ling Long, Tong-Ming Li and Yang Yu

International Journal of Biological Macromolecules, 2024, 262, 129936
DOI: 10.1016/j.ijbiomac.2024.129936

Recent advances in medicinal and edible homologous plant polysaccharides: Preparation, structure and prevention and treatment of diabetes

Lan Li, Jingchen Xie, Zhimin Zhang, Bohou Xia, Yamei Li, Yan Lin, Minjie Li, Ping Wu and Limei Lin

International Journal of Biological Macromolecules, 2024, 258, 128873
DOI: 10.1016/j.ijbiomac.2023.128873

Effects of chitosan guanidine on blood glucose regulation and gut microbiota in T2DM

Yuancheng Liu, Qingya Miao, Yang Liu and Mengmeng Jiang

International Journal of Biological Macromolecules, 2024, 279, 135422
DOI: 10.1016/j.ijbiomac.2024.135422

Synergistic Effects of Plant Polysaccharides and Probiotics: A Novel Dietary Approach for Parkinson’s Disease Intervention

Ye Jin, Lu Wang, Ruiting Lin, Jing He, Da Liu, Yang Liu and Yongzhi Deng

Pharmaceuticals, 2026, 19, 157
DOI: 10.3390/ph19010157

Lactiplantibacillus plantarum strain 84-3 and Staphylococcus aureus phages alleviate type 2-diabetes-induced S. aureus and BCAAs increases by PI3K/AKT/GLUT4 signaling pathway

Tingting Liang, Qihui Gu, Zhuang Liang, Tong Jiang, Ya Chen, Tong Chen, Bo Dong, Bing Gu and Qingping Wu

Food Science and Human Wellness, 2025, 14, 9250678
DOI: 10.26599/FSHW.2025.9250678

Recent advances in the extraction, purification, structural characterization, bioactivities, and applications of polysaccharides from Dioscorea opposita

Yanhe Lang and Zhiru Qian

Carbohydrate Research, 2026, 565, 109910
DOI: 10.1016/j.carres.2026.109910

Network pharmacology prediction to discover the potential pharmacological action mechanism of Rhizoma Dioscoreae for liver regeneration

Wei Liu, Wenyu Wang, Chenglong Tian, Ming-Zhong Sun, Shuqing Liu and Qinlong Liu

Korean J Physiol Pharmacol, 2024, 28, 479
DOI: 10.4196/kjpp.2024.28.5.479

Multiple fingerprinting and chromatography-immunoreactivity relationship of polysaccharides from Dioscorea opposite Thunb

Zhiying Bian, Jie Ding, Xin Zhang, Jingyi Zhang, Chuanxiang Zhang, Guichun Shang, Lihao Zhu, Yongqing Zhang, Qian Liu and Yuhong Liu

Food Chemistry, 2025, 464, 141891
DOI: 10.1016/j.foodchem.2024.141891

Sweet-Tasting Plants in regulating glucose metabolism: Mechanisms, applications and future directions

Yan Zheng, Yuqi Si, Xinyi Li, Shuran Jin, Yaling Chen and Xumeng Chen

Journal of Functional Foods, 2025, 135, 107089
DOI: 10.1016/j.jff.2025.107089

Prospects of yam (Dioscorea) polysaccharides: Structural features, bioactivities and applications

Luyao Zhang, Shirui Wang, Weimei Zhang, Guanglu Chang, Lanping Guo, Xia Li and Wenyuan Gao

Food Chemistry, 2024, 446, 138897
DOI: 10.1016/j.foodchem.2024.138897

Gut microbial fermentation promotes the intestinal anti-inflammatory activity of Chinese yam polysaccharides

Yajuan Bai, Yue Zhou, Ruifen Zhang, Yanxia Chen, Fengzhong Wang and Mingwei Zhang

Food Chemistry, 2023, 402, 134003
DOI: 10.1016/j.foodchem.2022.134003

Yam polysaccharide extraction, purification, structural features, and biological properties: A review

Chongbi Wei, Shaowa Lv, Lei Jiang, Fang Fang, Lei Liu, Shuang Sun, Yunjie Ma and Yuyan Guo

Carbohydrate Research, 2026, 559, 109746
DOI: 10.1016/j.carres.2025.109746

Effects of Dioscorea opposita polysaccharides on insulin resistance and gut microbiota in high-fat-diet induced type 2 diabetic rats

Wei Liu, Rumeng Jin, Fanyi Ma, Peng Zhao, Yuting Su, Jiani Wang, Yun Zhang, Ruijiao Wang, Jinhua Zhu and Xiuhua Liu

International Journal of Biological Macromolecules, 2025, 304, 141004
DOI: 10.1016/j.ijbiomac.2025.141004

Acidic polysaccharide CP-2 from Dioscoreae Rhizoma ameliorated acute alcoholic liver injury through the gut-liver axis and AMPK/PPAR pathway

Yujun Xie, Mingxing Tao, Xiaodong Yan, Xinxin Fan, Alamusi Bayoude, Yu Lu, Shuangli Zhao, Boyang Yu and Renshi Li

International Journal of Biological Macromolecules, 2025, 310, 143145
DOI: 10.1016/j.ijbiomac.2025.143145

Yao-Shan of traditional Chinese medicine: an old story for metabolic health

Shuangling Yang, Hongzhi Yang and Yaxing Zhang

Front. Pharmacol., 2023, 14
DOI: 10.3389/fphar.2023.1194026

Multi-level fingerprinting and immune activity evaluation for polysaccharides from Dioscorea opposita Thunb.

Chuanxiang Zhang, Jie Ding, Zhiying Bian, Xin Liu, Di Wang, Guiyun Cao, Lihao Zhu, Jin Zhang, Qian Liu and Yuhong Liu

International Journal of Biological Macromolecules, 2024, 280, 135767
DOI: 10.1016/j.ijbiomac.2024.135767

Effect of in vitro simulated gastrointestinal digestion on the antioxidant activity, molecular weight, and microstructure of polysaccharides from Chinese yam

Xiaojuan Feng, Nana Bie, Jingyao Li, Mengli Zhang, Yihua Feng, Tingting Ding, Yue Zhao and Chunling Wang

International Journal of Biological Macromolecules, 2022, 207, 873
DOI: 10.1016/j.ijbiomac.2022.03.154

Polysaccharides from Lycium barbarum, yam, and sunflower ameliorate colitis in a structure and intrinsic flora-dependent manner

Shanshan Zhang, Ruchen Zhou, Xiaoran Xie, Shanshan Xiong, Lixiang Li and Yanqing Li

Carbohydrate Polymers, 2025, 349, 122905
DOI: 10.1016/j.carbpol.2024.122905

A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition

Shiting Yu, Yiwen Zhang, Jiao Xi, Jiabao Feng, Tongde Xie, Daian Pan, Daqing Zhao, Jixiang Ren, Zhengqi Dong, Meichen Liu and Siming Wang

International Journal of Biological Macromolecules, 2026, 335, 149351
DOI: 10.1016/j.ijbiomac.2025.149351

Molecular mechanism and structure-activity relationships of natural source polysaccharides in intervening type 2 diabetes mellitus through antioxidant effects: A systematic review

Luyuan Yang, Hailu Hou, Hong Yan, Hongmei Deng, Borui Guan and Huaguo Chen

Carbohydrate Polymers, 2026, 377, 124830
DOI: 10.1016/j.carbpol.2025.124830

Research progress on the structure, derivatives, pharmacological activity, and drug carrier capacity of Chinese yam polysaccharides: A review

Yuanyuan Guo, Fangrui Liu, Jin Zhang, Jing Chen, Wenxiao Chen, Yongjian Hong, Jinghong Hu and Qian Liu

International Journal of Biological Macromolecules, 2024, 261, 129853
DOI: 10.1016/j.ijbiomac.2024.129853

Termite Fungus Comb Polysaccharides Alleviate Hyperglycemia and Hyperlipidemia in Type 2 Diabetic Mice by Regulating Hepatic Glucose/Lipid Metabolism and the Gut Microbiota

Haihan Xiao, Xudong Song, Peng Wang, Weilin Li, Senhua Qin, Chaofu Huang, Beimin Wu, Bao Jia, Qionghua Gao and Ziyi Song

IJMS, 2024, 25, 7430
DOI: 10.3390/ijms25137430

Plant Extracts for Type 2 Diabetes: Mechanisms, Clinical Implications and Future Directions—A Systematic Review

Yiqiang Wang, Xuan Liu and Qin Li

j biobased mat bioenergy, 2024, 18, 771
DOI: 10.1166/jbmb.2024.2418

Allantoin reduces glucotoxicity and lipotoxicity in a type 2 diabetes rat model by modulating the PI3K and MAPK signaling pathways

Yao Zhao, Ming Qiao, Xiaomei Wang, Xinjie Luo, Jianhua Yang and Junping Hu

Heliyon, 2024, 10, e34716
DOI: 10.1016/j.heliyon.2024.e34716

Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II

Dan Liang, Lu Liu, Yulin Qi, Feng Nan, Ju Huang, Shiyun Tang, Jianyuan Tang and Nianzhi Chen

Journal of Ethnopharmacology, 2024, 324, 117745
DOI: 10.1016/j.jep.2024.117745

Fructus Mori polysaccharides modulate the axial distribution of gut microbiota and fecal metabolites to improve symptoms of hyperglycemia in type 2 diabetic mice

Wang Pingping, Hu Changli, Li Qiaoyun, Wu Kegang, Chai Xianghua, Fu Xiong, Peng Yunping and Chen Chun

International Journal of Biological Macromolecules, 2025, 307, 141949
DOI: 10.1016/j.ijbiomac.2025.141949

A polysaccharide from Morchella esculenta mycelia: Structural characterization and protective effect on antioxidant stress on PC12 cells against H2O2-induced oxidative damage

Xintao Chen, Lei Wu, Yaru Lei, Hui Tang, Zhejiang Yan, Sijie Zhu, Tingchi Wen and Zhenyuan Zhu

International Journal of Biological Macromolecules, 2025, 298, 139886
DOI: 10.1016/j.ijbiomac.2025.139886

Bioactive Metabolites of Dioscorea Species and Their Potential Applications in Functional Food Development

Pengcheng Wang, Yashi Wang, Shiqi Liu, Kai Wang, Yuxuan Yao, Weizhen Liu, Donghui Li, Wei Wang, Bin Li and Yupei Yang

Foods, 2025, 14, 2537
DOI: 10.3390/foods14142537