A three-component, general and practical route for diastereoselective synthesis of aza-spirocyclic pyrazolones via a decarboxylative annulation process

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New J. Chem., 2021, 45, 2374
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Construction of a spiro[pyrazolone-4,2′-pyridoindole] scaffold via a [3 + 3] cycloaddition of 2-indolylmethanol with a 4-aminopyrazolone-derived azomethine ylide

Shah Nawaz, Yue Huang, Xiaoze Bao, Shiqiang Wei, Xingfu Wei, Jingping Qu and Baomin Wang

Org. Biomol. Chem., 2021, 19, 8530
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Enantioselective organocatalytic formal [3+2]-cycloaddition of isatin-derived ketimines with benzylidenemalononitriles and benzylidineindanones

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New J. Chem., 2021, 45, 22034
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Diastereoselective formal [3 + 3] cycloaddition of isatin-based α-(trifluoromethyl)imines with N,N′-dialkyloxyureas

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Stereoselective synthesis and applications of spirocyclic oxindoles

Alexander J. Boddy and James A. Bull

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Catalytic enantioselective synthesis of chiral 4-hydroxy 4′-substituted pyrazolones by the vinylogous aldol reaction of pyrazole-4,5-diones with 3-alkylidene-2-oxindoles

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New J. Chem., 2021, 45, 13747
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Synthesis of functionalized 3,2′-pyrrolidinyl spirooxindoles via domino 1,6-addition/annulation reactions of para-quinone methides and 3-chlorooxindoles

Xiaochen Tian, Yongxing Zhang, Weiwu Ren and Yang Wang

Org. Chem. Front., 2022, 9, 615
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Recent synthetic strategies of spiro-azetidin-2-one, -pyrrolidine, -indol(one) and -pyran derivatives-a review

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Iodine assisted synthesis of CF3 appended spirodihydrofuryl/cyclopropyl oxindoles by changing the active methylene sources

Thirupathi Reddy Penjarla, Maheshwar Kundarapu, Krishnan Rangan and Anupam Bhattacharya

Org. Biomol. Chem., 2020, 18, 9623
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Catalytic asymmetric [3 + 2] cycloaddition of pyrazolone-derived MBH carbonate: highly stereoselective construction of the bispiro-[pyrazolone-dihydropyrrole-oxindole] skeleton

Zhou Tian, Jing Jiang, Zhen-Hui Yan, Qing-Qing Luo, Gu Zhan, Wei Huang, Xiang Li and Bo Han

Chem. Commun., 2022, 58, 5363
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Convenient synthesis of spiro-pyrazolone–pyrrolidinones via ipso-cyclization of arylidene pyrazolones with 2-chloro-N-phenylacetamides

Kavyashree Kuppayya Gond and Mahagundappa Rachappa Maddani

New J. Chem., 2024, 48, 15866
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Recent advances in the applications of pyrazolone derivatives in enantioselective synthesis

Xiaoze Bao, Xingyue Wang, Jin-Miao Tian, Xinyi Ye, Baomin Wang and Hong Wang

Org. Biomol. Chem., 2022, 20, 2370
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An interrupted Corey–Chaykovsky reaction of designed azaarenium salts: synthesis of complex polycyclic spiro- and fused cyclopropanoids

Bara Singh, Arshad J. Ansari, Nirmal Malik and S. S. V. Ramasastry

Chem. Sci., 2023, 14, 6963
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Asymmetric synthesis of the perhydroepoxyethanoindole core via sequential [4 + 2]-addition/reduction/fluoroannulation reactions

Madavi S. Prasad and Murugesan Sivaprakash

Org. Biomol. Chem., 2023, 21, 339
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Recent advances in organocatalytic asymmetric multicomponent cascade reactions for enantioselective synthesis of spirooxindoles

Yongchao Wang, Angel A. Cobo and Annaliese K. Franz

Org. Chem. Front., 2021, 8, 4315
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Access to highly enantioselective and diastereoselective spirooxindole dihydrofuran fused pyrazolones

Prakash K. Warghude, Abhijeet S. Sabale and Ramakrishna G. Bhat

Org. Biomol. Chem., 2020, 18, 1794
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Diastereoselective synthesis of indolenine-based spiro[pyrazolone-4,2′-pyrrolidine] scaffolds via 1,3-dipolar cycloaddition of 4-aminopyrazolones, aldehydes, and indolenines

Shah Nawaz, Shiqiang Wei, Yue Huang, Wenyao Wang, Jingping Qu and Baomin Wang

Org. Biomol. Chem., 2021, 19, 6964
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Dinuclear zinc-catalyzed enantioselective formal [3 + 2] cycloaddition of N-2,2,2-trifluoroethylisatin ketimines with low reactivity aurone derivatives

Rui-Li Wang, Shi-Kun Jia, Ya-Jun Guo, Yang Yi, Yuan-Zhao Hua, Hui-Jie Lu and Min-Can Wang

Org. Biomol. Chem., 2021, 19, 8492
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Metal catalyzed asymmetric 1,3-dipolar cycloaddition of azomethine ylides: structural diversity at the dipole partner

Juan Carlos Carretero, Nuria Rodríguez and Javier Adrio

Chem. Commun., 2025, 61, 3821
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Efficient enantioselective synthesis of CF2H-containing dispiro[benzo[b]thiophene-oxindole-pyrrolidine]s via organocatalytic cycloaddition

Yabo Deng, Yongzhen Li, Yalan Wang, Shuo Sun, Sichao Ma, Pengfei Jia, Wenguang Li, Kairong Wang and Wenjin Yan

Org. Chem. Front., 2022, 9, 210
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Synthesis of difluoromethylated spiropyrazolones via [3 + 2] cycloaddition of difluoroacetohydrazonoyl bromides with alkylidene pyrazolones

Yang Feng, Yuanyuan Ren, Duoduo Tang, Ke-Hu Wang, Junjiao Wang, Danfeng Huang, Xiaobo Lv and Yulai Hu

Org. Biomol. Chem., 2024, 22, 2797
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Enantioselective synthesis of isoxazole-containing spirooxindole tetrahydroquinolines via squaramide-catalysed cascade reactions

Tong-Hao Li, Cheng Niu and Da-Ming Du

Org. Biomol. Chem., 2022, 20, 5582
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Synthesis of fully functionalised spiropyran pyrazolone skeletons via a formal [4 + 2] cascade process using β-nitro-styrene-derived MBH-alcohols

Yeruva Pavankumar Reddy and Shaik Anwar

RSC Adv., 2022, 12, 34634
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Asymmetric Metal‐Templated Approach to Amino Acids with a CF3‐Containing 3,2’‐Pyrrolidinyl Spirooxindole Core via a Michael/Mannich [3+2]‐Cycloaddition Reaction

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Adv Synth Catal, 2024, 366, 1205
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Catalytic Asymmetric Construction of Tertiary Carbon Centers Featuring an α-Difluoromethyl Group with CF2H-CH2-NH2 as the “Building Block”

Fengyun Gao, Yifei Guo, Mengmeng Sun, Yalan Wang, Changyan Yang, Yuqiang Wang, Kairong Wang and Wenjin Yan

Org. Lett., 2021, 23, 2584
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Recent Advances in the Construction of Trifluoromethyl‐Containing Spirooxindoles through Cycloaddition Reactions

Hou‐Ze Gui, Yin Wei and Min Shi

Chemistry An Asian Journal, 2020, 15, 1225
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Highly diastereoselective assembly of isoxazole and trifluoromethyl containing spiro[pyrrolidin-oxindoles] from N-2,2,2-trifluoroethyl-substituted isatin imines and styrylisoxazoles

Shuai-Jiang Liu, Qing Mao, Ya-Jun Zhong, Jing Xue, Ben-Hong Chen, Qian Zhao and Wei Huang

Tetrahedron Letters, 2021, 62, 152687
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N-Heterocyclic Carbene (NHC)-Catalyzed [3+2] Cycloaddition to Highly Diastereoselective Synthesis of Spirooxindole Dihydrofuran Fused Pyrazolone Compounds

Yan Liu, Xiaomei Wang, Lin He, Shiwu Li and Zhifei Zhao

Chinese Journal of Organic Chemistry, 2024, 44, 1301
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Recent Advances in Catalytic Enantioselective Synthesis of Pyrazolones with a Tetrasubstituted Stereogenic Center at the 4-Position

Laura Carceller-Ferrer, Gonzalo Blay, José R. Pedro and Carlos Vila

Synthesis, 2021, 53, 215
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Rapid entry to bispiro heterocycles merging five pharmacophores using phase-transfer catalysis

Lin Chen, Hui-Yan Geng, Zheng-Jun Chen, Wei Liang and Wen-Ya Jiao

Tetrahedron Letters, 2021, 78, 153276
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An Efficient Route to Access Spirooxindole–Pyrazolone-Fused Cyclopentenes by a Diastereoselective [3+2] Annulation

Abhijeet S. Sabale, Prakash K. Warghude and Ramakrishna G. Bhat

Synlett, 2023, 34, 1732
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Synthesis of 7′-Arylidenespiro[indoline-3,1′-pyrrolizines] and 7′-Arylidenespiro[indene-2,1′-pyrrolizines] via [3 + 2] Cycloaddition and β-C–H Functionalized Pyrrolidine

Ying Huang, Hui-Lin Fang, Yi-Xin Huang, Jing Sun and Chao-Guo Yan

J. Org. Chem., 2019, 84, 12437
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Recent Advances in Catalytic Asymmetric Reactions Involving Trifluoroethyl Ketimines

Zhongwen Sun, Congcong Zhang, Lijun Chen, Huiding Xie, Bo Liu and Dandan Liu

Chinese Journal of Organic Chemistry, 2021, 1789
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Non‐Covalent Organocascade Catalysis: Michael–Mannich Synergy for Enantioselective Building of Aza‐Spirocycles

Ram N Yadav, Luciana C. Schmidt, Ashok Kumar Srivastava and Md. Firoj Hossain

ChemCatChem, 2025, 17
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Recent Advances of N-2,2,2-Trifluoroethylisatin Ketimines in Organic Synthesis

Yuting Liu, Lijie Wang, Donglai Ma and Yongxing Song

Molecules, 2023, 28, 2990
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Synthesis of Chiral Spiro[oxindole-3,2′-pyrrolidine] Derivatives Integrated with Spiro Indane-1,3-dione and Trifluoromethyl Group Pharmacophores via Organocatalyzed Asymmetric [3+2] Annulation

Fei Li, Zhuo Li, Youming Wang and Zhenghong Zhou

Synthesis, 2023, 55, 1427
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Highly stereoselective organocatalytic synthesis of pyrrolidinyl spirooxindoles containing halogenated contiguous quaternary carbon stereocenters

Fei-Yu Chen, Li Xiang, Gu Zhan, Hong Liu, Bin Kang, Shu-Cang Zhang, Cheng Peng and Bo Han

Tetrahedron Letters, 2020, 61, 151806
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Bifunctinoal Phosphonium Salt‐Catalyzed Asymmetric Cyclodearomatization of 2‐Nitroindoles and 2‐Nitrobenzofurans for Constructing CF3‐Containing Spiro‐Polycycles

Zhiyu Jiang, Xin Liu, Hongkui Zhang, Jian‐Ping Tan, Xiaoyu Ren, Guowei Gao and Tianli Wang

Adv Synth Catal, 2021, 363, 3115
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Phase‐Transfer Catalytic Strategy: Rapid Synthesis of Spiro‐Fused Heterocycles, Integrated with Four Pharmacophores‐Succinimide, Pyrrolidine, Oxindole, and Trifluoromethyl Group

Zheng‐Jun Chen, Wei Liang, Zhuo Chen and Lin Chen

Eur J Org Chem, 2021, 2021, 788
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DMAP-catalyzed decarboxylative [3+2] cycloadditions: A strategy for diastereoselective synthesis of trifluoromethylated chromanone-fused pyrrolidinyl spirooxindoles

Xiong-Wei Liu, Jing Yue, Zheng Li, Dan Wu, Min-Yi Tian, Qi-Lin Wang and Ying Zhou

Tetrahedron, 2020, 76, 131678
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N-Heterocyclic Carbene-Catalyzed [4＋2] Cycloaddition of Salicylaldehydes with Pyrazole-4,5-diones for the Synthesis of Spiroketal-Pyrazolones

Xiaomei Wang, Yan Liu, Shiwu Li and Zhifei Zhao

Chinese Journal of Organic Chemistry, 2025, 45, 267
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Convenient Synthesis of Functionalized Spiropyrazolone‐Fused Pyrazolo[1,5‐c]Quinazolines via Catalyst‐Free (3 + 2) Cycloaddition of Quinazoline‐Derived Azomethine Imines With Arylidene Pyrazolones

Kai‐Kai Wang, Wen‐Jin Li, Yu Tang, Bo Hao, Jing Cao, Yi‐Xuan Lu, Yu Xiao, Rongxiang Chen and Guo‐Yi Yan

Journal of Heterocyclic Chem, 2026, 63, 483
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Squaramide Catalyzed Asymmetric Synthesis of Five‐ and Six‐Membered Rings

Anup Biswas, Avisek Ghosh, Rajat Shankhdhar and Indranil Chatterjee

Asian J Org Chem, 2021, 10, 1345
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Organocatalysis in 1,3-Dipolar Cycloaddition Reactions (A Review)

Yu. A. Pronina, L. A. Teglyai, A. I. Ponyaev, M. L. Petrov, V. M. Boitsov and A. V. Stepakov

Russ J Gen Chem, 2024, 94, 1
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Direct access to spirooxindole dihydropyrrole fused pyrazolones and bis-spiropyrazolone derivatives

Prakash K. Warghude, Anindita Bhowmick and Ramakrishna G. Bhat

Tetrahedron Letters, 2022, 97, 153791
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Recent Advances in Squaramide‐Catalyzed Asymmetric Mannich Reactions

Xi‐Qiang Hou and Da‐Ming Du

Adv Synth Catal, 2020, 362, 4487
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Brønsted Base and Lewis Acid Cooperatively Catalyzed Asymmetric exo′-Selective [3 + 2] Cycloaddition of Trifluoromethylated Azomethine Ylides and Methyleneindolinones

Yang Yi, Yuan-Zhao Hua, Hui-Jie Lu, Lan-Tao Liu and Min-Can Wang

Org. Lett., 2020, 22, 2527
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Construction of Chiral All‐Carbon Quaternary Stereocenters by Asymmetric Friedel−Crafts Reaction of Isatin Derivatives

Jindong Li, Wenjing Lu, Yangmian Lu, Zhenggen Zha and Zhiyong Wang

Chin. J. Chem., 2022, 40, 195
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Highly diastereoselective synthesis of trifluoromethyl containing spiro[pyrrolidin-3,2′-oxindoles] from N-2,2,2-trifluoroethylsubstituted isatin imines and β,γ-unsaturated α-keto esters

Ya Xiong, Xiao-Xue Han, Yu Lu, Hui-Juan Wang, Min Zhang and Xiong-Wei Liu

Tetrahedron, 2021, 87, 132112
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(4S,4'S)-2,2'-(4,6-Dibenzofurandiyl)bis[4,5-dihydro-4-phenyloxazole]-Ni(II) Complexes Catalyzed Highly Enantioselective Nitrile Imine Cycloaddition Reactions

Xixian Cao, Jun You, Qiye Liu, Bo Liu, Yanchao Yu and Wenju Wu

Chinese Journal of Organic Chemistry, 2024, 44, 2315
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Diastereoselective construction of structurally diverse trifluoromethyl bispiro-[oxindole-pyrrolidine-chromanone]s through [3+2] cycloaddition reactions

Zheng Li, Yu Lu, You-Ping Tian, Xiao-Xue Han, Xiang-Wei Liu, Ying Zhou and Xiong-Li Liu

Tetrahedron, 2021, 98, 132297
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Developments in Organocatalysis Transformations of Unsaturated Pyrazolones

Fatemeh Doraghi, Farzad Gilaninezhad, Somaye Karimian, Bagher Larijani and Mohammad Mahdavi

COS, 2025, 22, 439
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Photoredox‐Catalyzed Synthesis of a Novel Class of Fluoroalkyl Pyrazolones

Emanuele F. Pissinati, Meysam Azizzade, Till Opatz and Márcio W. Paixão

Adv Synth Catal, 2025, 367
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Recent Strategies in the Synthesis of Spiroindole and Spirooxindole Scaffolds

Shima Nasri, Mohammad Bayat and Faezeh Mirzaei

Top Curr Chem (Z), 2021, 379
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Asymmetric Addition and Cycloaddition Reactions with Ylidene‐Five‐Membered Heterocycles

Ricardo Torán, Rubén Miguélez, Amparo Sanz‐Marco, Carlos Vila, José R. Pedro and Gonzalo Blay

Adv Synth Catal, 2021, 363, 5196
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The Molecular Diversity Scope of Oxindole Derivatives in Organic Synthesis

Ghodsi Mohammadi Ziarani, Fatemeh Javadi and Fatemeh Mohajer

COC, 2021, 25, 779
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