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Integrating microfluidic and bioprinting technologies: advanced strategies for tissue vascularization
Xuan Mei, Ziyi Yang, Xiran Wang, Alan Shi, Joel Blanchard, Fanny Elahi, Heemin Kang, Gorka Orive and Yu Shrike Zhang
Lab Chip, 2025, 25, 764
DOI: 10.1039/D4LC00280F

Angiogenesis gene signatures in patient-derived tumor spheroids for genetic and tumor angiogenesis profiling
Sujin Hyung, Jihoon Ko, Minae An, Seung Tae Kim, Se Hoon Park, Jung Yong Hong, Sung Hee Lim, Kyoung-Mee Kim and Jeeyun Lee
J. Mater. Chem. B, 2025, 13, 11597
DOI: 10.1039/D5TB00577A

A microfluidic hanging drop-based spheroid co-culture platform for probing tumor angiogenesis
Didem Rodoplu, Jefunnie Sierra Matahum and Chia-Hsien Hsu
Lab Chip, 2022, 22, 1275
DOI: 10.1039/D1LC01177D

Spatially controlled diffusion range of tumor-associated angiogenic factors to develop a tumor model using a microfluidic resistive circuit
Yu-Hsiang Hsu, Wen-Chih Yang, Yi-Ting Chen, Che-Yu Lin, Chiou-Fong Yang, Wei-Wen Liu, Subhashree Shivani and Pai-Chi Li
Lab Chip, 2024, 24, 2644
DOI: 10.1039/D3LC00891F

Recent advances in spheroid-based microfluidic models to mimic the tumour microenvironment
Jooyoung Ro, Junyoung Kim and Yoon-Kyoung Cho
Analyst, 2022, 147, 2023
DOI: 10.1039/D2AN00172A

Low-cost rapid prototyping and assembly of an open microfluidic device for a 3D vascularized organ-on-a-chip
Qinyu Li, Kai Niu, Ding Wang, Lian Xuan and Xiaolin Wang
Lab Chip, 2022, 22, 2682
DOI: 10.1039/D1LC00767J

Angio-Net: deep learning-based label-free detection and morphometric analysis of in vitro angiogenesis
Suryong Kim, Jungseub Lee, Jihoon Ko, Seonghyuk Park, Seung-Ryeol Lee, Youngtaek Kim, Taeseung Lee, Sunbeen Choi, Jiho Kim, Wonbae Kim, Yoojin Chung, Oh-Heum Kwon and Noo Li Jeon
Lab Chip, 2024, 24, 751
DOI: 10.1039/D3LC00935A

Evaluating migration and cytotoxicity of tissue-resident and conventional NK cells in a 3D microphysiological system using live-cell imaging
Hyeri Choi, June Ho Shin, Hyeonsu Jo, John B. Sunwoo and Nool Li Jeon
Lab Chip, 2025, 25, 2696
DOI: 10.1039/D4LC01095G

Vascularized tissue on mesh-assisted platform (VT-MAP): a novel approach for diverse organoid size culture and tailored cancer drug response analysis
Jungseub Lee, Sangmin Jung, Hye Kyoung Hong, Hyeonsu Jo, Stephen Rhee, Ye-Lin Jeong, Jihoon Ko, Yong Beom Cho and Noo Li Jeon
Lab Chip, 2024, 24, 2208
DOI: 10.1039/D3LC01055D

A tumor spheroid array chip for high-fidelity evaluation of liposomal drug delivery through the EPR effect
Yedam Lee, Sujin Kim, Hyeyeon Koh, Yeonwoo Park, Jung Y. Han and Jihoon Ko
Lab Chip, 2026, 26, 2439
DOI: 10.1039/D5LC00893J

The vascular niche in next generation microphysiological systems
Makena L. Ewald, Yu-Hsi Chen, Abraham P. Lee and Christopher C. W. Hughes
Lab Chip, 2021, 21, 3244
DOI: 10.1039/D1LC00530H

On-chip-angiogenesis based on a high-throughput biomimetic three-dimensional cell spheroid culture system
Yachao Wang, Xuemei Zeng, Peng Chen, Wei Du, Yumei Pei, Guoping Wang and Bi-Feng Liu
Analyst, 2023, 148, 3870
DOI: 10.1039/D3AN00817G

Injection molded open microfluidic well plate inserts for user-friendly coculture and microscopy
John H. Day, Tristan M. Nicholson, Xiaojing Su, Tammi L. van Neel, Ivor Clinton, Anbarasi Kothandapani, Jinwoo Lee, Max H. Greenberg, John K. Amory, Thomas J. Walsh, Charles H. Muller, Omar E. Franco, Colin R. Jefcoate, Susan E. Crawford, Joan S. Jorgensen and Ashleigh B. Theberge
Lab Chip, 2020, 20, 107
DOI: 10.1039/C9LC00706G

Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies
Charlotte Bouquerel, Anastasiia Dubrova, Isabella Hofer, Duc T. T. Phan, Moencopi Bernheim, Ségolène Ladaigue, Charles Cavaniol, Danilo Maddalo, Luc Cabel, Fatima Mechta-Grigoriou, Claire Wilhelm, Gérard Zalcman, Maria Carla Parrini and Stéphanie Descroix
Lab Chip, 2023, 23, 3906
DOI: 10.1039/D3LC00531C

Multidimensional controllable fabrication of tumor spheroids based on a microfluidic device
Ying Hou, Yajing Zheng, Xiaonan Zheng, Yucheng Sun, Xizhen Yi, Zengnan Wu and Jin-Ming Lin
Lab Chip, 2023, 23, 2654
DOI: 10.1039/D3LC00251A

An engineered pancreatic cancer model with intra-tumoral heterogeneity of driver mutations
Hye-ran Moon, Altug Ozcelikkale, Yi Yang, Bennett D. Elzey, Stephen F. Konieczny and Bumsoo Han
Lab Chip, 2020, 20, 3720
DOI: 10.1039/D0LC00707B

Infrared imaging with visible light in microfluidic devices: the water absorption barrier
Mona Suryana, Thomas Produit, Hongzhi Yang, Giovanni Birarda, Jegan Vishnuwardhana Shanmugar, Leonid Krivitsky, Anna Paterova and Gianluca Grenci
Analyst, 2025, 150, 405
DOI: 10.1039/D4AN01201A

Cancer-on-chip technology: current applications in major cancer types, challenges and future prospects
Zakaria Baka, Marie Stiefel, Agathe Figarol, Claire Godier, Abhik Mallick, Olivier Joubert, Nureddin Ashammakhi, Eric Gaffet and Halima Alem
Prog. Biomed. Eng., 2022, 4, 032001
DOI: 10.1088/2516-1091/ac8259

Tumoroids, a valid preclinical screening platform for monitoring cancer angiogenesis
Zahra Abbasi-Malati, Parisa Khanicheragh, Maryam Taghavi Narmi, Narges Mardi, Nafiseh Didar Khosrowshahi, Amirataollah Hiradfar, Aysa Rezabakhsh, Fatemeh Sadeghsoltani, Somayyeh Rashidi, Sara Aghakhani Chegeni, Golbarg Roozbahani and Reza Rahbarghazi
Stem Cell Res Ther, 2024, 15
DOI: 10.1186/s13287-024-03880-4

3D cancer models: One step closer to in vitro human studies
Nicoletta Manduca, Ester Maccafeo, Ruggero De Maria, Antonella Sistigu and Martina Musella
Front. Immunol., 2023, 14
DOI: 10.3389/fimmu.2023.1175503

Microfluidics‐Molded Through‐Hole Membranes for 3D Culture Array‐Based Tumor Manipulation and Analysis
Meilin Sun, Kai Han, Dan Liu, Rui Hu and Wenming Liu
Adv Materials Technologies, 2020, 5
DOI: 10.1002/admt.202000084

Analysis of the Internal Hypoxic Environment in Solid Tumor Tissue Using a Folding Paper System
Chia-Hao Huang, Kowit-Yu Chong and Kin Fong Lei
ACS Appl. Mater. Interfaces, 2021, 13, 33885
DOI: 10.1021/acsami.1c08857

Imaging Technologies for Microfluidic Biochips
Jeongmoo Han, Ungyo Kang, Eun-Yi Moon, Hongki Yoo and Bomi Gweon
BioChip J, 2022, 16, 255
DOI: 10.1007/s13206-022-00067-y

Microfluidic Biofabrication of 3D Multicellular Spheroids by Modulation of Non-geometrical Parameters
Silvia Lopa, Francesco Piraino, Giuseppe Talò, Valerio Luca Mainardi, Simone Bersini, Margherita Pierro, Luigi Zagra, Marco Rasponi and Matteo Moretti
Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00366

3D micromesh-based hybrid bioprinting: multidimensional liquid patterning for 3D microtissue engineering
Byungjun Lee, Suryong Kim, Jihoon Ko, Seung-Ryeol Lee, Youngtaek Kim, Seonghyuk Park, Jiho Kim, Sujin Hyung, Ho-Young Kim and Noo Li Jeon
NPG Asia Mater, 2022, 14
DOI: 10.1038/s41427-022-00355-x

Nanofabrication Technologies to Control Cell and Tissue Function in Three-Dimension
Hidenori Otsuka
Gels, 2023, 9, 203
DOI: 10.3390/gels9030203

A high-throughput microfabricated platform for rapid quantification of metastatic potential
Smiti Bhattacharya, Abora Ettela, Jonathan Haydak, Chad M. Hobson, Alan Stern, Miran Yoo, Teng-Leong Chew, G. Luca Gusella, Emily J. Gallagher, James C. Hone and Evren U. Azeloglu
Sci. Adv., 2024, 10
DOI: 10.1126/sciadv.adk0015

3D bioprinted, vascularized neuroblastoma tumor environment in fluidic chip devices for precision medicine drug testing
Daniel Nothdurfter, Christian Ploner, Débora C Coraça-Huber, Doris Wilflingseder, Thomas Müller, Martin Hermann, Judith Hagenbuchner and Michael J Ausserlechner
Biofabrication, 2022, 14, 035002
DOI: 10.1088/1758-5090/ac5fb7

Emerging biomaterials and technologies to control stem cell fate and patterning in engineered 3D tissues and organoids
Mojtaba Farahani, James Carthew, Sanchyan Bhowmik, Chloe Shard, Ana Nunez-Nescolarde, Guillermo A. Gomez, Victor J. Cadarso, Alexander N. Combes and Jessica E. Frith
Biointerphases, 2022, 17
DOI: 10.1116/6.0002034

Current Advances in 3D Dynamic Cell Culture Systems
Xin Huang, Zhengxiang Huang, Weidong Gao, Wendong Gao, Ruiying He, Yulin Li, Ross Crawford, Yinghong Zhou, Lan Xiao and Yin Xiao
Gels, 2022, 8, 829
DOI: 10.3390/gels8120829

High‐Scale 3D‐Bioprinting Platform for the Automated Production of Vascularized Organs‐on‐a‐Chip
Anna Fritschen, Nils Lindner, Sebastian Scholpp, Philipp Richthof, Jonas Dietz, Philipp Linke, Zeno Guttenberg and Andreas Blaeser
Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202304028

Advances in hydrogel-based vascularized tissues for tissue repair and drug screening
Ying Wang, Ranjith Kumar Kankala, Caiwen Ou, Aizheng Chen and Zhilu Yang
Bioactive Materials, 2022, 9, 198
DOI: 10.1016/j.bioactmat.2021.07.005

Microvascularized tumor organoids-on-chips: advancing preclinical drug screening with pathophysiological relevance
Jungeun Lim, Hanna Ching, Jeong-Kee Yoon, Noo Li Jeon and YongTae Kim
Nano Convergence, 2021, 8
DOI: 10.1186/s40580-021-00261-y

Osteosarcoma tumor microenvironment: the key for the successful development of biologically relevant 3D in vitro models
João Rodrigues, Bruno Sarmento and Catarina Leite Pereira
In vitro models, 2022, 1, 5
DOI: 10.1007/s44164-022-00008-x

Advances in Spheroids and Organoids on a Chip
Guocheng Fang, Yu‐Cheng Chen, Hongxu Lu and Dayong Jin
Adv Funct Materials, 2023, 33
DOI: 10.1002/adfm.202215043

Multilayered microfluidic platform for three-dimensional vascularized organ-on-a-chip applications
Chenyang Zhou, Zhangjie Li, Jiaqi Xu, Dingyuan Yu, Lian Xuan and Xiaolin Wang
Bio-des. Manuf., 2025, 8, 930
DOI: 10.1631/bdm.2500091

3D microengineered vascularized tumor spheroids for drug delivery and efficacy testing
Jungho Ahn, Da-Hyun Kim, Dong-Jun Koo, Jungeun Lim, Tae-Eun Park, Jungseub Lee, Jihoon Ko, Seongchan Kim, Minjae Kim, Kyung-Sun Kang, Dal-Hee Min, Sung-Yon Kim, YongTae Kim and Noo Li Jeon
Acta Biomaterialia, 2023, 165, 153
DOI: 10.1016/j.actbio.2022.10.009

Culture of cancer spheroids and evaluation of anti-cancer drugs in 3D-printed miniaturized continuous stirred tank reactors (mCSTRs)
Salvador Gallegos-Martínez, Itzel Montserrat Lara-Mayorga, Mohamadmahdi Samandari, Christian Mendoza-Buenrostro, Brenda Giselle Flores-Garza, Luisa María Reyes-Cortés, Juan Carlos Segoviano-Ramírez, Yu Shrike Zhang, Grissel Trujillo-de Santiago and Mario Moisés Álvarez
Biofabrication, 2022, 14, 035007
DOI: 10.1088/1758-5090/ac61a4

Vascularization of iNSC spheroid in a 3D spheroid‐on‐a‐chip platform enhances neural maturation
Nari Shin, Youngtaek Kim, Jihoon Ko, Soon Won Choi, Sujin Hyung, Seung‐Eun Lee, Seunghyuk Park, Jiyoung Song, Noo Li Jeon and Kyung‐Sun Kang
Biotech & Bioengineering, 2022, 119, 566
DOI: 10.1002/bit.27978

Unlocking the Potential of Spheroids in Personalized Medicine: A Systematic Review of Seeding Methodologies
Karolina M. Lonkwic, Radosław Zajdel and Krzysztof Kaczka
IJMS, 2025, 26, 6478
DOI: 10.3390/ijms26136478

Three-dimensional in vitro culture models in oncology research
Camille Jubelin, Javier Muñoz-Garcia, Laurent Griscom, Denis Cochonneau, Emilie Ollivier, Marie-Françoise Heymann, François M. Vallette, Lisa Oliver and Dominique Heymann
Cell Biosci, 2022, 12
DOI: 10.1186/s13578-022-00887-3

Organ‐on‐a‐Chip Fabrication Using Dynamic Photomask
Terry Ching, Shu‐Yung Chang, Takanobu Takenouchi, Yu Shrike Zhang, Yi‐Chin Toh and Michinao Hashimoto
Small Methods, 2026, 10
DOI: 10.1002/smtd.202400416

On-chip Raman spectroscopy of live single cells for the staging of oesophageal adenocarcinoma progression
Alisha Farooq, Christopher D. Wood, John E. Ladbury and Stephen D. Evans
Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-52079-3

Biosensors integrated 3D organoid/organ-on-a-chip system: A real-time biomechanical, biophysical, and biochemical monitoring and characterization
Shan Liu, Shikha Kumari, Hongyi He, Parichita Mishra, Bhisham Narayan Singh, Divakar Singh, Sutong Liu, Pradeep Srivastava and Chenzhong Li
Biosensors and Bioelectronics, 2023, 231, 115285
DOI: 10.1016/j.bios.2023.115285

Bevacizumab and anlotinib combination therapy acts via HIF-1α suppression to exert synergistic anti-angiogenic and anti-tumor effects in non-small cell lung cancer
Nafeisha Simayi, Jiaying Li, Junkai Hu, Ning Jia, Rongxue Wan, Jinbiao Xie and Wenhua Huang
Front. Immunol., 2025, 16
DOI: 10.3389/fimmu.2025.1613368

Biosynthetic, biomimetic, and self-assembled vascularized Organ-on-a-Chip systems
Anna Fritschen and Andreas Blaeser
Biomaterials, 2021, 268, 120556
DOI: 10.1016/j.biomaterials.2020.120556

Augmented 3D Printing for Multiscale Microphysiological Systems
Kyeong Seob Hwang, Jiyoung Song, Hyun Wook Kang, Jongbaeg Kim, Cheol Woo Ha, Nakwon Choi, Seokyoung Bang and Hong Nam Kim
Small, 2025, 21
DOI: 10.1002/smll.202504750

Bibliometric study of plastics microfluidic chip from 1994 to 2022: A review
Rhesa Muhammad Faisal, Olusola Olaitan Ayeleru, Helen Uchenna Modekwe and Ishmael Matala Ramatsa
Heliyon, 2025, 11, e42102
DOI: 10.1016/j.heliyon.2025.e42102

Challenges of applying multicellular tumor spheroids in preclinical phase
Se Jik Han, Sangwoo Kwon and Kyung Sook Kim
Cancer Cell Int, 2021, 21
DOI: 10.1186/s12935-021-01853-8

Advancements and challenges in SLA-based microfluidic devices for organ-on-chip applications
Francisca Barbosa, Paula Coutinho, Maximiano P. Ribeiro, André F. Moreira, Luís M. Lourenço and Sónia P. Miguel
Materials & Design, 2025, 256, 114254
DOI: 10.1016/j.matdes.2025.114254

AI‐Driven Microphysiological Systems for Advancing Nanoparticle Therapeutics
Yedam Lee, Jaehong Min, Sujin Kim and Jihoon Ko
Advanced Intelligent Systems, 2025, 7
DOI: 10.1002/aisy.202500022

Organ-on-a-Chip Platforms for Drug Screening and Delivery in Tumor Cells: A Systematic Review
Inês M. Gonçalves, Violeta Carvalho, Raquel O. Rodrigues, Diana Pinho, Senhorinha F. C. F. Teixeira, Ana Moita, Takeshi Hori, Hirokazu Kaji, Rui Lima and Graça Minas
Cancers, 2022, 14, 935
DOI: 10.3390/cancers14040935

3D Microphysiological System‐Inspired Scalable Vascularized Tissue Constructs for Regenerative Medicine
Seokyoung Bang, Dongha Tahk, Young Hwan Choi, Somin Lee, Jungeun Lim, Seung‐Ryeol Lee, Byung‐Soo Kim, Hong Nam Kim, Nathaniel S. Hwang and Noo Li Jeon
Adv Funct Materials, 2022, 32
DOI: 10.1002/adfm.202105475

Three-Dimensional Vascularized Lung Cancer-on-a-Chip with Lung Extracellular Matrix Hydrogels for In Vitro Screening
Sangun Park, Tae Kim, Soo Kim, Seungkwon You and Youngmee Jung
Cancers, 2021, 13, 3930
DOI: 10.3390/cancers13163930

Vascularized tumor models for the evaluation of drug delivery systems: a paradigm shift
Elliot Lopez-Vince, Claire Wilhelm and Teresa Simon-Yarza
Drug Deliv. and Transl. Res., 2024, 14, 2216
DOI: 10.1007/s13346-024-01580-3

One-step achievement of tumor spheroid-induced angiogenesis in a high-throughput microfluidic platform: one-step tumor angiogenesis platform
Seonghyuk Park, Youngtaek Kim, Jihoon Ko, Jiyoung Song, Jeeyun Lee, Young-Kwon Hong and Noo Li Jeon
Organoid, 2023, 3, e3
DOI: 10.51335/organoid.2023.3.e3

In vitro modeling of solid tumor interactions with perfused blood vessels
Tae Joon Kwak and Esak Lee
Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-77180-1

Investigating the Interactions of Glioma Stem Cells in the Perivascular Niche at Single‐Cell Resolution using a Microfluidic Tumor Microenvironment Model
Emmanuela A. Adjei‐Sowah, Samantha A. O'Connor, Jaimeson Veldhuizen, Costanza Lo Cascio, Christopher Plaisier, Shwetal Mehta and Mehdi Nikkhah
Advanced Science, 2022, 9
DOI: 10.1002/advs.202201436

Recent Advances in Three-Dimensional Multicellular Spheroid Culture and Future Development
Honglin Shen, Shuxiang Cai, Chuanxiang Wu, Wenguang Yang, Haibo Yu and Lianqing Liu
Micromachines, 2021, 12, 96
DOI: 10.3390/mi12010096

A method for reproducible high‐resolution imaging of 3D cancer cell spheroids
Thomas A. Phillips, Valeria Caprettini, Nandini Aggarwal, Stefania Marcotti, Rob Tetley, Yanlan Mao, Tanya Shaw, Ciro Chiappini, Maddy Parsons and Susan Cox
Journal of Microscopy, 2023, 291, 30
DOI: 10.1111/jmi.13169

Clinically Relevant Tissue Scale Responses as New Readouts from Organs-on-a-Chip for Precision Medicine
Olivier T. Guenat, Thomas Geiser and François Berthiaume
Annual Rev. Anal. Chem., 2020, 13, 111
DOI: 10.1146/annurev-anchem-061318-114919

A Facile and Scalable Hydrogel Patterning Method for Microfluidic 3D Cell Culture and Spheroid-in-Gel Culture Array
Chengxun Su, Yon Jin Chuah, Hong Boon Ong, Hui Min Tay, Rinkoo Dalan and Han Wei Hou
Biosensors, 2021, 11, 509
DOI: 10.3390/bios11120509

Building Blood Vessel Chips with Enhanced Physiological Relevance
Xuan Mu, Marie Denise Gerhard‐Herman and Yu Shrike Zhang
Adv Materials Technologies, 2023, 8
DOI: 10.1002/admt.202201778

From Spheroids to Tumor-on-a-Chip for Cancer Modeling and Therapeutic Testing
Maria Veronica Lipreri, Marilina Tamara Totaro, Nicola Baldini and Sofia Avnet
Micromachines, 2025, 16, 1343
DOI: 10.3390/mi16121343

In vitro vascularized tumor platform for modeling tumor‐vasculature interactions of inflammatory breast cancer
Manasa Gadde, Caleb Phillips, Neda Ghousifam, Anna G. Sorace, Enoch Wong, Savitri Krishnamurthy, Anum Syed, Omar Rahal, Thomas E. Yankeelov, Wendy A. Woodward and Marissa N. Rylander
Biotech & Bioengineering, 2020, 117, 3572
DOI: 10.1002/bit.27487

Microphysiological systems as reliable drug discovery and evaluation tools: Evolution from innovation to maturity
Hye-Ran Moon, Nishanth Surianarayanan, Tarun Singh and Bumsoo Han
Biomicrofluidics, 2023, 17
DOI: 10.1063/5.0179444

In vitro 3D Systems to Model Tumor Angiogenesis and Interactions With Stromal Cells
Noémie Brassard-Jollive, Catherine Monnot, Laurent Muller and Stéphane Germain
Front. Cell Dev. Biol., 2020, 8
DOI: 10.3389/fcell.2020.594903

Angiogenic Sprouting Dynamics Mediated by Endothelial‐Fibroblast Interactions in Microfluidic Systems
Noosheen Walji, Sina Kheiri and Edmond W. K. Young
Advanced Biology, 2021, 5
DOI: 10.1002/adbi.202101080

Multi-organ-on-chip approach in cancer research
Agnieszka Zuchowska and Sandra Skorupska
Organs-on-a-Chip, 2022, 4, 100014
DOI: 10.1016/j.ooc.2021.100014

In Vitro Models of Blood and Lymphatic Vessels—Connecting Tissues and Immunity
Amanda Bogseth, Ann Ramirez, Erik Vaughan and Katharina Maisel
Advanced Biology, 2023, 7
DOI: 10.1002/adbi.202200041

The Role of Mechanical Properties and Structure of Type I Collagen Hydrogels on Colorectal Cancer Cell Migration
Hector Castro‐Abril, Jónathan Heras, Jesús del Barrio, Laura Paz, Clara Alcaine, Marina Pérez Aliácar, Diego Garzón‐Alvarado, Manuel Doblaré and Ignacio Ochoa
Macromolecular Bioscience, 2023, 23
DOI: 10.1002/mabi.202300108

Organoids for Cancer Research: Advances and Challenges
Miaomaio Xin, Qian Li, Dongyang Wang and Zheng Wang
Advanced Biology, 2024, 8
DOI: 10.1002/adbi.202400056

Microfluidic high-throughput 3D cell culture
Jihoon Ko, Dohyun Park, Jungseub Lee, Sangmin Jung, Kyusuk Baek, Kyung E. Sung, Jeeyun Lee and Noo Li Jeon
Nat Rev Bioeng, 2024, 2, 453
DOI: 10.1038/s44222-024-00163-8

The Edifice of Vasculature-On-Chips: A Focused Review on the Key Elements and Assembly of Angiogenesis Models
Joshua Lim, Hsu-Wei Fang, Sasinan Bupphathong, Po-Chan Sung, Chen-En Yeh, Wei Huang and Chih-Hsin Lin
ACS Biomater. Sci. Eng., 2024, 10, 3548
DOI: 10.1021/acsbiomaterials.3c01978

Molecular insights of metastasis and cancer progression derived using 3D cancer spheroid co-culture in vitro platform
Unnati Modi, Pooja Makwana and Rajesh Vasita
Critical Reviews in Oncology/Hematology, 2021, 168, 103511
DOI: 10.1016/j.critrevonc.2021.103511

Organ-on-Chip platforms to study tumor evolution and chemosensitivity
Venzil Lavie Dsouza, Raviprasad Kuthethur, Shama Prasada Kabekkodu and Sanjiban Chakrabarty
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2022, 1877, 188717
DOI: 10.1016/j.bbcan.2022.188717

Technological Advances in Tumor-On-Chip Technology: From Bench to Bedside
Santa Bērziņa, Alexandra Harrison, Valérie Taly and Wenjin Xiao
Cancers, 2021, 13, 4192
DOI: 10.3390/cancers13164192

Flow‐IMPACT: A Pumpless, High‐Throughput 3D Cell Culture Platform for Investigation of Synergistic Angiogenic Effects
Seonghyuk Park, Youngtaek Kim, Jungseub Lee, Sangmin Jung, Jongho Hong, Suryong Kim, Seung‐Ryeol Lee, Jiyoung Song, Siwan Park, Young Sun Oh, Jihoon Ko and Noo Li Jeon
Adv Materials Technologies, 2025, 10
DOI: 10.1002/admt.202401526

A 3D vascularized tumor spheroid microfluidic platform for head and neck cancer research: new insights
Jooin Bang, Jiyoung Yeo, Su Ji Lee, Hansol Lee, Jinyoung Kim, Sohyeon Jeong, Eeseul Kang, Hoon Suk Rho, YongTae Kim and Jun-Ook Park
Biomed Microdevices, 2025, 27
DOI: 10.1007/s10544-025-00748-z

An Easy-to-Fabricate Microfluidic Shallow Trench Induced Three-Dimensional Cell Culturing and Imaging (STICI3D) Platform
Umut Can Coskun, Funda Kus, Ateeq Ur Rehman, Berna Morova, Merve Gulle, Hatice Baser, Demet Kul, Alper Kiraz, Kemal Baysal and Ahmet Erten
ACS Omega, 2022, 7, 8281
DOI: 10.1021/acsomega.1c05118

Study of Drug Resistance in Chemotherapy Induced by Extracellular Vesicles on a Microchip
Tianyuan Fang, Wei Lu, Jingfeng Zhang, Ke Ge, Zhanhong Chen, Min Wang and Bo Yao
Anal. Chem., 2022, 94, 16919
DOI: 10.1021/acs.analchem.2c04330

On-chip modeling of tumor evolution: Advances, challenges and opportunities
Chengpan Li, Joseph Benjamin Holman, Zhengdi Shi, Bensheng Qiu and Weiping Ding
Materials Today Bio, 2023, 21, 100724
DOI: 10.1016/j.mtbio.2023.100724

Scaffold‐based spheroid models of glioblastoma multiforme and its use in drug screening
Ceera Manikandan and Amit Kumar Jaiswal
Biotech & Bioengineering, 2023, 120, 2117
DOI: 10.1002/bit.28481

Spheroids in cancer research: Recent advances and opportunities
Sanchit Arora, Somay Singh, Anuj Mittal, Nimeet Desai, Dharmendra Kumar Khatri, Dalapathi Gugulothu, Viney Lather, Deepti Pandita and Lalitkumar K. Vora
Journal of Drug Delivery Science and Technology, 2024, 100, 106033
DOI: 10.1016/j.jddst.2024.106033

Emerging tumor-on-chips with electrochemical biosensors
Lanjie Lei, Biao Ma, Chengtao Xu and Hong Liu
TrAC Trends in Analytical Chemistry, 2022, 153, 116640
DOI: 10.1016/j.trac.2022.116640

Recent advances in sex-specific reproductive microphysiological systems for the systematic evaluation of assisted reproductive technology
Minkyeong Jeong, Kiyeon Park, Dawit Jung, Sieun Shin, Jungseub Lee, Jihoon Ko, Seokyoung Bang and Jungho Ahn
Materials Today Bio, 2026, 38, 103050
DOI: 10.1016/j.mtbio.2026.103050

Reducing tumor invasiveness by ramucirumab and TGF‐β receptor kinase inhibitor in a diffuse‐type gastric cancer patient‐derived cell model
Song‐Yi Lee, Seonggyu Byeon, Jihoon Ko, Sujin Hyung, In‐Kyoung Lee, Noo Li Jeon, Jung Yong Hong, Seung Tae Kim, Se Hoon Park and Jeeyun Lee
Cancer Medicine, 2021, 10, 7253
DOI: 10.1002/cam4.4259

Tumor spheroid-based and microtumor-based vascularized models for replicating the vascularized tumor microenvironment
Jiyoung Song, Jihoon Ko, Nakwon Choi, Noo Li Jeon and Hong Nam Kim
Organoid, 2023, 3, e6
DOI: 10.51335/organoid.2023.3.e6

Cancer-on-chip: a 3D model for the study of the tumor microenvironment
Elisa Cauli, Michela Anna Polidoro, Simona Marzorati, Claudio Bernardi, Marco Rasponi and Ana Lleo
J Biol Eng, 2023, 17
DOI: 10.1186/s13036-023-00372-6

Anti-Cancer Activity Profiling of Chemotherapeutic Agents in 3D Co-Cultures of Pancreatic Tumor Spheroids with Cancer-Associated Fibroblasts and Macrophages
So-Dam Jang, Jeeyeun Song, Hyun-Ah Kim, Chang-Nim Im, Iftikhar Ali Khawar, Jong Kook Park and Hyo-Jeong Kuh
Cancers, 2021, 13, 5955
DOI: 10.3390/cancers13235955

All‐in‐one microfluidic design to integrate vascularized tumor spheroid into high‐throughput platform
Youngtaek Kim, Jihoon Ko, Nari Shin, Seonghyuk Park, Seung‐Ryeol Lee, Suryong Kim, Jiyoung Song, Seokjun Lee, Kyung‐Sun Kang, Jeeyun Lee and Noo Li Jeon
Biotech & Bioengineering, 2022, 119, 3678
DOI: 10.1002/bit.28221

Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro
Thomas Collins, Emily Pyne, Martin Christensen, Alexander Iles, Nicole Pamme and Isabel M. Pires
Biomicrofluidics, 2021, 15
DOI: 10.1063/5.0061373

A Dynamic 3D Tumor Spheroid Chip Enables More Accurate Nanomedicine Uptake Evaluation
Jialang Zhuang, Jie Zhang, Minhao Wu and Yuanqing Zhang
Advanced Science, 2019, 6
DOI: 10.1002/advs.201901462

Microfluidic System to Analyze the Effects of Interleukin 6 on Lymphatic Breast Cancer Metastasis
Hyeon-Yeol Cho, Jin-Ha Choi, Kyeong-Jun Kim, Minkyu Shin and Jeong-Woo Choi
Front. Bioeng. Biotechnol., 2021, 8
DOI: 10.3389/fbioe.2020.611802

3D Cancer Models: Depicting Cellular Crosstalk within the Tumour Microenvironment
Teresa Franchi-Mendes, Rodrigo Eduardo, Giacomo Domenici and Catarina Brito
Cancers, 2021, 13, 4610
DOI: 10.3390/cancers13184610

Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system
Chutong Tian, Shunzhe Zheng, Xinying Liu and Ken-ichiro Kamei
J Nanobiotechnol, 2022, 20
DOI: 10.1186/s12951-022-01552-0

The Importance of Spheroids in Analyzing Nanomedicine Efficacy
Inês Mó, Ivo J Sabino, Duarte de Melo-Diogo, Rita Lima-Sousa, Cátia G Alves and Ilídio J Correia
Nanomedicine (Lond.), 2020, 15, 1513
DOI: 10.2217/nnm-2020-0054

Facile Photopatterning of Perfusable Microchannels in Synthetic Hydrogels to Recreate Microphysiological Environments
Ana Mora‐Boza, Adriana Mulero‐Russe, Nikolas Di Caprio, Jason A. Burdick, Ankur Singh and Andrés J. García
Advanced Materials, 2023, 35
DOI: 10.1002/adma.202306765

Evaluation of nanoparticle albumin-bound paclitaxel loaded macrophages for glioblastoma treatment based on a microfluidic chip
Zuorun Xie, Junyi Ye, Xinghua Gao, Hang Chen, Maosong Chen, Jiangfang Lian, Jingyun Ma and Hongcai Wang
Front. Bioeng. Biotechnol., 2024, 12
DOI: 10.3389/fbioe.2024.1361682

Anchor‐IMPACT: A standardized microfluidic platform for high‐throughput antiangiogenic drug screening
Suryong Kim, Jihoon Ko, Seung‐Ryeol Lee, Dohyun Park, Seunghyuk Park and Noo Li Jeon
Biotech & Bioengineering, 2021, 118, 2524
DOI: 10.1002/bit.27765

Exploring the Complexity of Cutaneous Squamous CellCarcinoma Microenvironment: Focus on Immune Cell Roles by Novel 3D In Vitro Models
Marika Quadri, Marco Iuliano, Paolo Rosa, Giorgio Mangino and Elisabetta Palazzo
Life, 2025, 15, 1170
DOI: 10.3390/life15081170

Vascularized Tumor‐on‐a‐Chip Model as a Platform for Studying Tumor‐Microenvironment‐Drug Interaction
Hyelim Kim, Seung‐Woo Cho and Hong Nam Kim
Macromolecular Bioscience, 2025, 25
DOI: 10.1002/mabi.202500240

In Vitro Human Cancer Models for Biomedical Applications
Jane Choi, Gül Kozalak, Ighli di Bari, Quratulain Babar, Zahra Niknam, Yousef Rasmi and Kar Yong
Cancers, 2022, 14, 2284
DOI: 10.3390/cancers14092284

Patient-derived exosomes facilitate therapeutic targeting of oncogenic MET in advanced gastric cancer
Sujin Hyung, Jihoon Ko, You Jeong Heo, Steven M. Blum, Seung Tae Kim, Se Hoon Park, Joon Oh Park, Won Ki Kang, Ho Yeong Lim, Samuel J. Klempner and Jeeyun Lee
Sci. Adv., 2023, 9
DOI: 10.1126/sciadv.adk1098

Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction
Claudia Tanja Mierke
Front. Cell Dev. Biol., 2022, 10
DOI: 10.3389/fcell.2022.789841

Compelling standardized and high-throughput micro-/millifluidic plates for biomedical research: from laboratory to market
Longjun Gu, Peidi Liu, Wen Zhao, Yuhang Fan, Yuwen Wang and Pu Chen
MedMat, 2025, 2, 101
DOI: 10.1097/mm9.0000000000000016

Bioengineering Stem Cell-Derived Glioblastoma Organoids: A Comprehensive Review
Alexandra D. Avera and Yonghyun Kim
Pharmaceuticals, 2025, 18, 1830
DOI: 10.3390/ph18121830

Advanced Cellular Models for Preclinical Drug Testing: From 2D Cultures to Organ-on-a-Chip Technology
Valentina Foglizzo, Emiliano Cocco and Serena Marchiò
Cancers, 2022, 14, 3692
DOI: 10.3390/cancers14153692

Pump‐Less Platform Enables Long‐Term Recirculating Perfusion of 3D Printed Tubular Tissues
Feng Zhang, Dawn S. Y. Lin, Shravanthi Rajasekar, Alexander Sotra and Boyang Zhang
Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202300423

Genetically Engineered Filamentous Bacteriophages Displaying TGF-β1 Promote Angiogenesis in 3D Microenvironments
In-Hyuk Baek, Volkhard Helms and Youngjun Kim
JFB, 2024, 15, 314
DOI: 10.3390/jfb15110314

Construction of a Fibroblast-Associated Tumor Spheroid Model Based on a Collagen Drop Array Chip
Hyewon Roh, Hwisoo Kim and Je-Kyun Park
Biosensors, 2021, 11, 506
DOI: 10.3390/bios11120506

Multi-niche human bone marrow on-a-chip for studying the interactions of adoptive CAR-T cell therapies with multiple myeloma
Delta Ghoshal, Ingrid Petersen, Rachel Ringquist, Liana Kramer, Eshant Bhatia, Thomas Hu, Ariane Richard, Reda Park, Jenna Corbin, Savi Agarwal, Abel Thomas, Sebastian Ramirez, Jacob Tharayil, Emma Downey, Frank Ketchum, Abigail Ochal, Neha Sonthi, Sagar Lonial, James N. Kochenderfer, Reginald Tran, Mandy Zhu, Wilbur A. Lam, Ahmet F. Coskun and Krishnendu Roy
Biomaterials, 2025, 316, 123016
DOI: 10.1016/j.biomaterials.2024.123016

A polysaccharide-based hydrogel platform for tumor spheroid production and anticancer drug screening
Elliot Lopez-Vince, Teresa Simon-Yarza and Claire Wilhelm
Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-87896-7

Spatiotemporal Heterogeneity of Tumor Glucose Metabolism Reprogramming: From Single-Cell Mechanisms to Precision Interventions
Xiaoxue Chai, Qian Tao and Lili Li
IJMS, 2025, 26, 6901
DOI: 10.3390/ijms26146901

Spheroid‐on‐a‐Chip Platforms for Tumor Microenvironment and Drug Development
Pierre Claver Uzabakiriho, Fan Jiajun, Benedictor Alexander Nguchu, Sajid Iqbal, Clarisse Manishimwe and Peter Shaw
Adv Materials Technologies, 2025, 10
DOI: 10.1002/admt.202401821

From cell spheroids to vascularized cancer organoids: Microfluidic tumor-on-a-chip models for preclinical drug evaluations
Yue Wu, Yuyuan Zhou, Xiaochen Qin and Yaling Liu
Biomicrofluidics, 2021, 15
DOI: 10.1063/5.0062697

Three-dimensional heterotypic colorectal cancer spheroid models for evaluation of drug response
Jia Ning Nicolette Yau and Giulia Adriani
Front. Oncol., 2023, 13
DOI: 10.3389/fonc.2023.1148930

3D printed microfluidics for cell biological applications
Liang Zhao and Xiayan Wang
TrAC Trends in Analytical Chemistry, 2023, 158, 116864
DOI: 10.1016/j.trac.2022.116864

U-IMPACT: a universal 3D microfluidic cell culture platform
Seung-Ryeol Lee, Youngtaek Kim, Suryong Kim, Jiho Kim, Seonghyuk Park, Stephen Rhee, Dohyun Park, Byungjun Lee, Kyusuk Baek, Ho-Young Kim and Noo Li Jeon
Microsyst Nanoeng, 2022, 8
DOI: 10.1038/s41378-022-00431-w

Recapitulating the Cancer‐Immunity Cycle on a Chip
Yujin Lee, Jaehong Min, Solbin Kim, Wooju Park, Jihoon Ko and Noo Li Jeon
Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202401927

Novel 3D µtissues Mimicking the Fibrotic Stroma in Pancreatic Cancer to Study Cellular Interactions and Stroma-Modulating Therapeutics
Kunal P. Pednekar, Marcel A. Heinrich, Joop van Baarlen and Jai Prakash
Cancers, 2021, 13, 5006
DOI: 10.3390/cancers13195006

Recent Advances on Cell-Based Co-Culture Strategies for Prevascularization in Tissue Engineering
Sepehr Shafiee, Siavash Shariatzadeh, Ali Zafari, Alireza Majd and Hassan Niknejad
Front. Bioeng. Biotechnol., 2021, 9
DOI: 10.3389/fbioe.2021.745314

Engineering Organ-on-a-Chip to Accelerate Translational Research
Jihoon Ko, Dohyun Park, Somin Lee, Burcu Gumuscu and Noo Jeon
Micromachines, 2022, 13, 1200
DOI: 10.3390/mi13081200

On-Chip Replication of Extremely Early-Stage Tumor Behavior
Chengpan Li, Shibo Li, Kun Du, Ping Li, Bensheng Qiu and Weiping Ding
ACS Appl. Mater. Interfaces, 2021, 13, 19768
DOI: 10.1021/acsami.1c03740

Aspiration-mediated hydrogel micropatterning using rail-based open microfluidic devices for high-throughput 3D cell culture
Dohyun Park, Jungseub Lee, Younggyun Lee, Kyungmin Son, Jin Woo Choi, William J. Jeang, Hyeri Choi, Yunchan Hwang, Ho-Young Kim and Noo Li Jeon
Sci Rep, 2021, 11
DOI: 10.1038/s41598-021-99387-6

A Novel Ex Vivo Tumor Spheroid-Tissue Model for Investigating Microvascular Remodeling and Lymphatic Blood Vessel Plasticity
Arinola O. Lampejo, Suzanne E. Lightsey, Maria C. Gomes, Christian M. Nguyen, Dietmar W. Siemann, Blanka Sharma and Walter L. Murfee
Ann Biomed Eng, 2024, 52, 2457
DOI: 10.1007/s10439-024-03535-8

Lab-On-A-Chip for the Development of Pro-/Anti-Angiogenic Nanomedicines to Treat Brain Diseases
Subhathirai Subramaniyan Parimalam, Simona Badilescu, Nahum Sonenberg, Rama Bhat and Muthukumaran Packirisamy
IJMS, 2019, 20, 6126
DOI: 10.3390/ijms20246126

Engineered Vasculature for Organ-on-a-Chip Systems
Abdellah Aazmi, Hongzhao Zhou, Yuting Li, Mengfei Yu, Xiaobin Xu, Yutong Wu, Liang Ma, Bin Zhang and Huayong Yang
Engineering, 2022, 9, 131
DOI: 10.1016/j.eng.2021.06.020

Fibrosis‐on‐Chip: A Guide to Recapitulate the Essential Features of Fibrotic Disease
Emma M. Streutker, Utku Devamoglu, Madelon C. Vonk, Wouter P. R. Verdurmen and Séverine Le Gac
Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202303991

Microfluidics in High-Throughput Drug Screening: Organ-on-a-Chip and C. elegans-Based Innovations
Sunhee Yoon, Dilara Kilicarslan You, Uiechan Jeong, Mina Lee, Eunhye Kim, Tae-Joon Jeon and Sun Min Kim
Biosensors, 2024, 14, 55
DOI: 10.3390/bios14010055

3D Printing for Cardiovascular Applications: From End-to-End Processes to Emerging Developments
Ramtin Gharleghi, Claire A. Dessalles, Ronil Lal, Sinead McCraith, Kiran Sarathy, Nigel Jepson, James Otton, Abdul I. Barakat and Susann Beier
Ann Biomed Eng, 2021, 49, 1598
DOI: 10.1007/s10439-021-02784-1

A guide to the organ-on-a-chip
Chak Ming Leung, Pim de Haan, Kacey Ronaldson-Bouchard, Ge-Ah Kim, Jihoon Ko, Hoon Suk Rho, Zhu Chen, Pamela Habibovic, Noo Li Jeon, Shuichi Takayama, Michael L. Shuler, Gordana Vunjak-Novakovic, Olivier Frey, Elisabeth Verpoorte and Yi-Chin Toh
Nat Rev Methods Primers, 2022, 2
DOI: 10.1038/s43586-022-00118-6

Magnetically Integrated Tumor–Vascular Interface System to Mimic Pro-angiogenic Endothelial Dysregulations for On-Chip Drug Testing
Vikram Surendran, Simrit Safarulla, Christian Griffith, Reem Ali, Ankit Madan, William Polacheck and Arvind Chandrasekaran
ACS Appl. Mater. Interfaces, 2024, 16, 47075
DOI: 10.1021/acsami.4c01766

A vascularized tumors-on-a-chip model for studying tumor-angiogenesis interplay, heterogeneity and drug responses
Suyeon Shin, Yurim Choi, WonJun Jang, Batjargal Ulziituya, Giheon Ha, Raehui Kang, Soojin Park, Minseok Kim, Yu Shrike Zhang, Han-Jun Kim and Junmin Lee
Materials Today Bio, 2025, 32, 101741
DOI: 10.1016/j.mtbio.2025.101741

Pump‐Free Unidirectional Vertical Centrifugal Microfluidic Platform for Dynamic 3D Tumor Cluster Culture and Functional Drug Screening
Ke Ning, Yuanyuan Xie, Xiaoyan Yang, Yirong Chen, Wen Sun, Jinhua Chen, Jingtao Zhu, Yan Li, Yingshuai Liu and Ling Yu
Adv Healthcare Materials, 2026, 15
DOI: 10.1002/adhm.202504241

Design of an Integrated Microvascularized Human Skin-on-a-Chip Tissue Equivalent Model
Christian F. E. Jones, Stefania Di Cio, John T. Connelly and Julien E. Gautrot
Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.915702

Development of Tumor-Vasculature Interaction on Chip Mimicking Vessel Co-Option of Glioblastoma
Jinseung Bae, Min-Hyeok Kim, Seokgyu Han and Sungsu Park
BioChip J, 2023, 17, 77
DOI: 10.1007/s13206-022-00090-z

Design patterns of tumor-on-chips utilizing fluidic devices and their latest trends
Nobuhito Mori and Yasuyuki S. Kida
DDS, 2024, 39, 184
DOI: 10.2745/dds.39.184

Advances in the construction of human organs-on-chips
Yi Zeng and Zhongze Gu
Chin. Sci. Bull., 2023, 68, 4954
DOI: 10.1360/TB-2023-0435

Modeling 3D Human Tumor Lymphatic Vessel Network Using High‐Throughput Platform
Somin Lee, Habin Kang, Dohyun Park, James Yu, Seung Kwon Koh, Duck Cho, Da‐Hyun Kim, Kyung‐Sun Kang and Noo Li Jeon
Advanced Biology, 2021, 5
DOI: 10.1002/adbi.202000195

Inner ear organoids: progress and outlook, with a focus on the vascularization
Farideh Moeinvaziri, Ibrahim Zarkesh, Paria Pooyan, Desmond A. Nunez and Hossein Baharvand
The FEBS Journal, 2022, 289, 7368
DOI: 10.1111/febs.16146

A digital manufactured microfluidic platform for flexible construction of 3D co-culture tumor model with spatiotemporal resolution
Chao Han, Renchao Zhang, Xiwen He, Yuan Fang, Gang Cen, Weidong Wu, Chen Huang and Xiang Chen
Biofabrication, 2025, 17, 015029
DOI: 10.1088/1758-5090/ad9636

Advances in human organs-on-chips and applications for drug screening and personalized medicine
Chenyang Zhou, Zhangjie Li, Kangyi Lu, Yijun Liu, Lian Xuan, Hongju Mao and Xiaolin Wang
Fundamental Research, 2025, 5, 1258
DOI: 10.1016/j.fmre.2023.12.019

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk
Marina Green Buzhor, Giuseppe Longobardi, Or Kandli, Anne Krinsky, Opal Avramoff, Anshika Katyal, Koren Salomon, Adan Miari, Dana Venkert, Tania T. Barnatan, América García Alvarado, Shahar Greenberg and Ronit Satchi‐Fainaro
Adv Healthcare Materials, 2026, 15
DOI: 10.1002/adhm.202503198

Glioma-on-a-Chip Models
Merve Ustun, Sajjad Rahmani Dabbagh, Irem Ilci, Tugba Bagci-Onder and Savas Tasoglu
Micromachines, 2021, 12, 490
DOI: 10.3390/mi12050490

Bridging the Gap: How Organ‐on‐a‐Chip Technology Facilitates the Battle against Glioma
Su Liu, Zhenyu Gong, Dairan Zhou, Vanesa Ayala‐Nunez, Tao Xu and Peter Wick
Small Science, 2026, 6
DOI: 10.1002/smsc.202500154

Progressive hypoxia‐on‐a‐chip: An in vitro oxygen gradient model for capturing the effects of hypoxia on primary hepatocytes in health and disease
Young Bok (Abraham) Kang, Jinsu Eo, Beyza Bulutoglu, Martin L. Yarmush and O. Berk Usta
Biotech & Bioengineering, 2020, 117, 763
DOI: 10.1002/bit.27225

Review: 3D cell models for organ-on-a-chip applications
Agnieszka Żuchowska, Patrycja Baranowska, Magdalena Flont, Zbigniew Brzózka and Elżbieta Jastrzębska
Analytica Chimica Acta, 2024, 1301, 342413
DOI: 10.1016/j.aca.2024.342413

Cadherin‐6 is a novel mediator for the migration of mesenchymal stem cells to glioblastoma cells in response to stromal cell‐derived factor‐1
Aran Park, Seung‐Eun Kim, Jinyeong Yu, Donghyun Son, Kyung‐Sup Kim, Eunjin Koh and Ki‐Sook Park
FEBS Open Bio, 2024, 14, 1192
DOI: 10.1002/2211-5463.13815

Direct Microextrusion Printing of a Low Viscosity Hydrogel on a Supportive Microstructured Bioprinting Substrate for the Vasculogenesis of Endothelial Cells
Soo Jee Kim, Gihyun Lee and Je‐Kyun Park
Adv Materials Technologies, 2022, 7
DOI: 10.1002/admt.202101326

Recent advances in microfluidic technology and applications for anti-cancer drug screening
Yiwei Shi, Ying Cai, Yuhong Cao, Zhanying Hong and Yifeng Chai
TrAC Trends in Analytical Chemistry, 2021, 134, 116118
DOI: 10.1016/j.trac.2020.116118

Real-Time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-Chip
Natalia Feiner-Gracia, Adrianna Glinkowska Mares, Marina Buzhor, Romen Rodriguez-Trujillo, Josep Samitier Marti, Roey J. Amir, Silvia Pujals and Lorenzo Albertazzi
ACS Appl. Bio Mater., 2021, 4, 669
DOI: 10.1021/acsabm.0c01209

New Strategy for Promoting Vascularization in Tumor Spheroids in a Microfluidic Assay
Zhengpeng Wan, Marie A. Floryan, Mark F. Coughlin, Shun Zhang, Amy X. Zhong, Sarah E. Shelton, Xun Wang, Chenguang Xu, David A. Barbie and Roger D. Kamm
Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202201784

Microengineered 3D Tumor Models for Anti-Cancer Drug Discovery in Female-Related Cancers
Farbod Amirghasemi, Emmanuela Adjei-Sowah, Barbara A. Pockaj and Mehdi Nikkhah
Ann Biomed Eng, 2021, 49, 1943
DOI: 10.1007/s10439-020-02704-9

Patient‐Derived Microphysiological Systems for Precision Medicine
Jihoon Ko, Jiyoung Song, Nakwon Choi and Hong Nam Kim
Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202303161

Reprogrammed Lung Metastasis Immunodeficiency via Targeted Penetrated Delivery of M1 Macrophage‐Wrapped NanoCubes‐Mediated T Cell Infiltration
Kang‐Li Wang, Cheng‐Han Li, Pin‐Xuan Huang, Hsiu‐Ching Liu, Bhanu Nirosha Yalamandala, Wan‐Chi Pan, Hoi Man Iao and Shang‐Hsiu Hu
Small, 2025, 21
DOI: 10.1002/smll.202406790

Tissue-engineered vascular microphysiological platform to study immune modulation of xenograft rejection
Tae Hee Kim, Ji-Jing Yan, Joon Young Jang, Gwang-Min Lee, Sun-Kyung Lee, Beom Seok Kim, Justin J. Chung, Soo Hyun Kim, Youngmee Jung and Jaeseok Yang
Sci. Adv., 2021, 7
DOI: 10.1126/sciadv.abg2237

Towards Cellular Ultrastructural Characterization in Organ-on-a-Chip by Transmission Electron Microscopy
Adrianna Glinkowska Mares, Natalia Feiner-Gracia, Yolanda Muela, Gema Martínez, Lidia Delgado, Lorenzo Albertazzi and Silvia Pujals
Applied Nano, 2021, 2, 289
DOI: 10.3390/applnano2040021

The future of personalized cardiovascular medicine demands 3D and 4D printing, stem cells, and artificial intelligence
Monique Bax, Jordan Thorpe and Valentin Romanov
Front. Sens., 2023, 4
DOI: 10.3389/fsens.2023.1294721

Biomaterials meet organ-on-chips – a perspective on tumor modeling
Cátia F. Monteiro, Inês A. Deus, Catarina A. Custódio and João F. Mano
International Materials Reviews, 2025, 70, 31
DOI: 10.1177/09506608241303436

Advances and applications of organ-on-a-chip technology
Jeong Sik Kong, Jisoo Kim, Jinah Jang and Dong-Woo Cho
Cell Reports Methods, 2026, 6, 101361
DOI: 10.1016/j.crmeth.2026.101361

Recent advances in 3D models of tumor invasion
Della S. Shin and Kristi S. Anseth
Current Opinion in Biomedical Engineering, 2021, 19, 100310
DOI: 10.1016/j.cobme.2021.100310

Cancer Models on Chip: Paving the Way to Large‐Scale Trial Applications
João Ferreira Gil, Carla Sofia Moura, Vania Silverio, Gil Gonçalves and Hélder A. Santos
Advanced Materials, 2023, 35
DOI: 10.1002/adma.202300692

Microfluidic platforms in diagnostic of ovarian cancer
Farnaz Dabbagh Moghaddam, Delara Dadgar, Yasaman Esmaeili, Shahrzad Babolmorad, Ehsan Ilkhani, Maedeh Rafiee, Xiang-Dong Wang and Pooyan Makvandi
Environmental Research, 2023, 237, 117084
DOI: 10.1016/j.envres.2023.117084

Bioprinted Organoids Platform with Tumor Vasculature for Implementing Precision Personalized Medicine Targeted Towards Gastric Cancer
Jisoo Kim, Jungmin Kim, Ge Gao, Yoo‐mi Choi, Jaewook Kim, Dong‐Woo Cho, Jae‐Ho Cheong and Jinah Jang
Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202306676

Vascularized organoid-on-a-chip: design, imaging, and analysis
Tingting Yu, Qihang Yang, Bo Peng, Zhongze Gu and Dan Zhu
Angiogenesis, 2024, 27, 147
DOI: 10.1007/s10456-024-09905-z

3D Microfluidic Platform and Tumor Vascular Mapping for Evaluating Anti-Angiogenic RNAi-Based Nanomedicine
Somin Lee, Seongchan Kim, Dong-Jun Koo, James Yu, Hyeongjun Cho, Hyojin Lee, Joon Myong Song, Sung-Yon Kim, Dal-Hee Min and Noo Li Jeon
ACS Nano, 2021, 15, 338
DOI: 10.1021/acsnano.0c05110

Recent Advances of Organ-on-a-Chip in Cancer Modeling Research
Xingxing Liu, Qiuping Su, Xiaoyu Zhang, Wenjian Yang, Junhua Ning, Kangle Jia, Jinlan Xin, Huanling Li, Longfei Yu, Yuheng Liao and Diming Zhang
Biosensors, 2022, 12, 1045
DOI: 10.3390/bios12111045

Advances of 3D Cell Co-Culture Technology Based on Microfluidic Chips
Can Li, Wei He, Yihua Song, Xia Zhang, Jianfei Sun and Zuojian Zhou
Biosensors, 2024, 14, 336
DOI: 10.3390/bios14070336

3D In Vitro Platform for Cell and Explant Culture in Liquid-like Solids
Duy T. Nguyen, Jack E. Famiglietti, Ryan A. Smolchek, Zadia Dupee, Nickolas Diodati, Diego I. Pedro, Juan M. Urueña, Matthew A. Schaller and W. Gregory Sawyer
Cells, 2022, 11, 967
DOI: 10.3390/cells11060967

Angiogenesis and Functional Vessel Formation Induced by Interstitial Flow and Vascular Endothelial Growth Factor Using a Microfluidic Chip
Yufang Liu, Jiao Li, Jiasheng Zhou, Xue Liu, Huibing Li, Yao Lu, Bingcheng Lin, Xiaojie Li and Tingjiao Liu
Micromachines, 2022, 13, 225
DOI: 10.3390/mi13020225

Cell Culture Model Evolution and Its Impact on Improving Therapy Efficiency in Lung Cancer
Viviana Roman, Mirela Mihaila, Nicoleta Radu, Stefania Marineata, Carmen Cristina Diaconu and Marinela Bostan
Cancers, 2023, 15, 4996
DOI: 10.3390/cancers15204996

Engineered hydrogels for brain tumor culture and therapy
Jai Thakor, Samad Ahadian, Ali Niakan, Ethan Banton, Fatemeh Nasrollahi, Mohammad M. Hasani-Sadrabadi and Ali Khademhosseini
Bio-des. Manuf., 2020, 3, 203
DOI: 10.1007/s42242-020-00084-6

Tumor spheroid-based microtumor models for preclinical evaluation of anticancer nanomedicines
Iftikhar Ali Khawar, Torsha Ghosh, Jong Kook Park and Hyo-Jeong Kuh
J. Pharm. Investig., 2021, 51, 541
DOI: 10.1007/s40005-021-00534-y

Microfluidics and Organoids, the Power Couple of Developmental Biology and Oncology Studies
Laura Ann Hetzel, Ahmed Ali, Vincenzo Corbo and Thomas Hankemeier
IJMS, 2023, 24, 10882
DOI: 10.3390/ijms241310882