Non-invasive diagnostic test for lung cancer using biospectroscopy and variable selection techniques in saliva samples

Camilo L. M. Morais, Kássio M. G. Lima, Andrew W. Dickinson, Tarek Saba, Thomas Bongers, Maneesh N. Singh, Francis L. Martin and Danielle Bury

Analyst, 2024, 149, 4851
DOI: 10.1039/D4AN00726C

Blind source separation of molecular components of the human skinin vivo: non-negative matrix factorization of Raman microspectroscopy data

B. P. Yakimov, A. V. Venets, J. Schleusener, V. V. Fadeev, J. Lademann, E. A. Shirshin and M. E. Darvin

Analyst, 2021, 146, 3185
DOI: 10.1039/D0AN02480E

Towards development of a novel universal medical diagnostic method: Raman spectroscopy and machine learning

Nicole M. Ralbovsky and Igor K. Lednev

Chem. Soc. Rev., 2020, 49, 7428
DOI: 10.1039/D0CS01019G

Enhanced characterization of breast cancer phenotypes using Raman micro-spectroscopy on stainless steel substrate

Giju Thomas, Sean T. Fitzgerald, Rekha Gautam, Fuyao Chen, Ezekiel Haugen, Pratheepa Kumari Rasiah, Wilson R. Adams and Anita Mahadevan-Jansen

Anal. Methods, 2023, 15, 1188
DOI: 10.1039/D2AY01764D

High reliability Ag/Ni/NiO nanowire-based SERS for cancer detection: a study on breast cancer

Alondra Hernandez Cedillo, Javier Mendez-Lozoya, Coral Hernandez Cedillo, Alfred L. M. Bothwell and Miguel Jose Yacaman

Nanoscale Adv., 2026, 8, 1197
DOI: 10.1039/D5NA00890E

Raman-Based Techniques in Medical Applications for Diagnostic Tasks: A Review

Yulia Khristoforova, Lyudmila Bratchenko and Ivan Bratchenko

IJMS, 2023, 24, 15605
DOI: 10.3390/ijms242115605

Solitary pulmonary nodule imaging approaches and the role of optical fibre-based technologies

Susan Fernandes, Gareth Williams, Elvira Williams, Katjana Ehrlich, James Stone, Neil Finlayson, Mark Bradley, Robert R. Thomson, Ahsan R. Akram and Kevin Dhaliwal

Eur Respir J, 2021, 57, 2002537
DOI: 10.1183/13993003.02537-2020

Artificial Intelligence in Chemistry: Current Trends and Future Directions

Zachary J. Baum, Xiang Yu, Philippe Y. Ayala, Yanan Zhao, Steven P. Watkins and Qiongqiong Zhou

J. Chem. Inf. Model., 2021, 61, 3197
DOI: 10.1021/acs.jcim.1c00619

Power of Light: Raman Spectroscopy and Machine Learning for the Detection of Lung Cancer

Harun Hano, Charles H. Lawrie, Beatriz Suarez, Alfredo Paredes Lario, Ibone Elejoste Echeverría, Jenifer Gómez Mediavilla, Marina Izaskun Crespo Cruz, Eneko Lopez and Andreas Seifert

ACS Omega, 2024, 9, 14084
DOI: 10.1021/acsomega.3c09537

Correlation and Difference Between Raman Spectral Characteristic and Feature Evaluation for Leukocytes and Tumor Cells

Yixin Dai, Wenxue Li, Liu Wang, Chuan Luo, Qing Huang and Lin Pang

Appl Spectrosc, 2021, 75, 1516
DOI: 10.1177/00037028211050663

Towards Raman-Based Screening of Acute Lymphoblastic Leukemia-Type B (B-ALL) Subtypes

Patrycja Leszczenko, Aleksandra Borek-Dorosz, Anna Maria Nowakowska, Adriana Adamczyk, Sviatlana Kashyrskaya, Justyna Jakubowska, Marta Ząbczyńska, Agata Pastorczak, Kinga Ostrowska, Malgorzata Baranska, Katarzyna Maria Marzec and Katarzyna Majzner

Cancers, 2021, 13, 5483
DOI: 10.3390/cancers13215483

Detection of lung cancer through SERS analysis of serum

Jiamin Shi, Rui Li, Yuchen Wang, Chenlei Zhang, Xiaohong Lyu, Yuan Wan and Zhanwu Yu

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 314, 124189
DOI: 10.1016/j.saa.2024.124189

Early Detection of Pre-Cancerous and Cancerous Cells Using Raman Spectroscopy-Based Machine Learning

Uraib Sharaha, Daniel Hania, Itshak Lapidot, Ahmad Salman and Mahmoud Huleihel

Cells, 2023, 12, 1909
DOI: 10.3390/cells12141909

Application of Fourier transform infrared (FTIR) spectroscopy in liquid biopsy to predict the response to the first-line immunotherapy in non-small-cell lung cancer (NSCLC) patients

Natalia Galant, Marcin Nicoś, Maryna Khalavka, Natalia Krzyżanowska, Izabela Chmielewska, Barbara Kuźnar-Kamińska, Paweł Krawczyk, Anna Sroka-Bartnicka and Joanna Depciuch

Biochemical and Biophysical Research Communications, 2025, 771, 152007
DOI: 10.1016/j.bbrc.2025.152007

A Review on Integrated ZnO-Based SERS Biosensors and Their Potential in Detecting Biomarkers of Neurodegenerative Diseases

Alia Colniță, Vlad-Alexandru Toma, Ioana Andreea Brezeștean, Muhammad Ali Tahir and Nicoleta Elena Dina

Biosensors, 2023, 13, 499
DOI: 10.3390/bios13050499

Novel aspects of Raman spectroscopy in skin research

Dominique Lunter, Victoria Klang, Dorottya Kocsis, Zsófia Varga‐Medveczky, Szilvia Berkó and Franciska Erdő

Experimental Dermatology, 2022, 31, 1311
DOI: 10.1111/exd.14645

Time‐resolved fluorescence and diffuse reflectance for lung squamous carcinoma margin detection

Sarah Costa, Qiyin Fang, Thomas Farrell, Erica Dao and Michael Farquharson

Lasers Surg Med, 2024, 56, 279
DOI: 10.1002/lsm.23761

Discrimination of Healthy and Cancerous Colon Cells Based on FTIR Spectroscopy and Machine Learning Algorithms

Maria Lasalvia, Crescenzio Gallo, Vito Capozzi and Giuseppe Perna

Applied Sciences, 2023, 13, 10325
DOI: 10.3390/app131810325

Raman imaging and chemometric methods in human normal bronchial and cancer lung cells: Raman biomarkers of lipid reprogramming

Monika Kopec, Karolina Beton-Mysur and Halina Abramczyk

Chemistry and Physics of Lipids, 2023, 257, 105339
DOI: 10.1016/j.chemphyslip.2023.105339

Rapid detection of lung cancer based on serum Raman spectroscopy and a support vector machine: a case-control study

Linfang Yan, Huiting Su, Jiafei Liu, Xiaozheng Wen, Huaichao Luo, Yu Yin and Xiaoqiang Guo

BMC Cancer, 2024, 24
DOI: 10.1186/s12885-024-12578-y

Characterization of Serum Biochemical Changes in Response to Alcohol Consumption Using FT‐Raman Spectroscopy

Hasan Mırsal, Zeynep Ceylan, Devrim Sarıbal, Joseph Cebulski, Joanna Depciuch and Zozan Guleken

J Raman Spectroscopy, 2025, 56, 25
DOI: 10.1002/jrs.6739

Analysis of liquid biopsy by Raman spectroscopy to facilitate prediction of response to immunotherapy in non-small-cell lung cancer (NSCLC) patients

Natalia Galant, Marcin Nicoś, Adrianna Kryska, Natalia Krzyżanowska, Tomasz Jankowski, Barbara Kuźnar-Kamińska, Paweł Krawczyk, Anna Sroka-Bartnicka and Joanna Depciuch

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2026, 344, 126750
DOI: 10.1016/j.saa.2025.126750

Fused Raman spectroscopic analysis of blood and saliva delivers high accuracy for head and neck cancer diagnostics

Hanna J. Koster, Antonio Guillen-Perez, Juan Sebastian Gomez-Diaz, Maria Navas-Moreno, Andrew C. Birkeland and Randy P. Carney

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-22197-x

Serum laser Raman spectroscopy as a potential diagnostic tool to discriminate the benignancy or malignancy of pulmonary nodules

Huaichao Luo, Ruiling Zu, Lintao Li, Yao Deng, Shuya He, Xing Yin, Kaijiong Zhang, Qiao He, Yu Yin, Gang Yin, Dezhong Yao and Dongsheng Wang

iScience, 2023, 26, 106693
DOI: 10.1016/j.isci.2023.106693

Enhancing lung cancer diagnostics through Raman spectroscopy and machine learning

Rahat Ullah, Kiran Parveen, Imran Rehan and Saranjam Khan

Phys. Scr., 2025, 100, 046015
DOI: 10.1088/1402-4896/adc214

Characterization and discrimination of spike protein in SARS‐CoV‐2 virus‐like particles via surface‐enhanced Raman spectroscopy

Munevver Akdeniz, Zakarya Al‐Shaebi, Mine Altunbek, Canan Bayraktar, Alisan Kayabolen, Tugba Bagci‐Onder and Omer Aydin

Biotechnology Journal, 2024, 19
DOI: 10.1002/biot.202300191

Advancing clinical diagnostics: the potential of analytical Raman spectroscopy in oncology, dermatology, and diabetes

Rabia’tul A’dawiah, Alicia Ann May Yap, Poongkulali Rajarahm, Songhua Zheng, Ruochong Zhang, Yi Qi, Dinish U.S., Wenyi Xu, Ghayathri Balasundaram, Malini Olivo and Renzhe Bi

Applied Spectroscopy Reviews, 2025, 60, 776
DOI: 10.1080/05704928.2025.2485280

AI‐Guided SERS Defines a Pan‐Cancer Diagnostic Biomarker

Cai Zhang, Wen‐Hui Zhao, Duo Zuo, Tianxing Zhou, Wenjing Hou, Lingwei Wang, Shangheng Shi, Yang Yang, Yuanyuan Liu, Shao‐Kai Sun, Li Ren, Zhaoxiang Ye, Dingbin Liu, Dong Li, Xiaoyuan Chen and Jihui Hao

Advanced Science, 2026, 13
DOI: 10.1002/advs.202516268

Mining Global and Local Semantics From Unlabeled Spectra for Spectral Classification

Wei Luo, Haiming Yao, Ang Gao, Tao Zhou and Xue Wang

IEEE J. Biomed. Health Inform., 2026, 30, 808
DOI: 10.1109/JBHI.2025.3588122

Identification of meat species by combined laser-induced breakdown and Raman spectroscopies

Haoran Sun, Chao Song, Xiaomei Lin and Xun Gao

Spectrochimica Acta Part B: Atomic Spectroscopy, 2022, 194, 106456
DOI: 10.1016/j.sab.2022.106456

Clinical applications of Raman and FTIR spectroscopy for noninvasive diagnosis and management of lung cancer

Natalia Galant, Marcin Nicoś, Anna Sroka-Bartnicka and Paweł Krawczyk

Applied Spectroscopy Reviews, 2025, 1
DOI: 10.1080/05704928.2025.2560316

A Practical Nanoplasmonic SERS Substrate for Differential Diagnosis of Lung Normal and Cancer Cells through Multivariate Statistical Analysis

Bini Abraham, Neethu Emmanuel, Nandu Ajikumar, Sanoop Pulassery, Liya Elsa Varghese, Vishnu Priya Murali, Arun Munnilath, Kasutabh Kumar Maiti and Karuvath Yoosaf

ChemNanoMat, 2023, 9
DOI: 10.1002/cnma.202300378

Reconstructing Randomly Masked Spectra Helps DNNs Identify Discriminant Wavenumbers

Yingying Wu, Jinchao Liu, Yan Wang, Stuart Gibson, Margarita Osadchy and Yongchun Fang

IEEE Trans. Pattern Anal. Mach. Intell., 2024, 46, 3845
DOI: 10.1109/TPAMI.2023.3347617

Electrochemical ultrasensitive detection of CYFRA21-1 using Ti3C2Tx-MXene as enhancer and covalent organic frameworks as labels

Jiamin Cheng, Kai Hu, Qianrui Liu, Yanju Liu, Huaixia Yang and Jinming Kong

Anal Bioanal Chem, 2021, 413, 2543
DOI: 10.1007/s00216-021-03212-y

Advanced bronchoscopic techniques for the diagnosis and treatment of peripheral lung cancer

Tess Kramer and Jouke T. Annema

Lung Cancer, 2021, 161, 152
DOI: 10.1016/j.lungcan.2021.09.015

Utility of Raman Spectroscopy in Pulmonary Medicine

Pauls Dzelve, Arta Legzdiņa, Andra Krūmiņa and Madara Tirzīte

ARM, 2024, 92, 421
DOI: 10.3390/arm92050038

Assignment of Regioisomers Using Infrared Spectroscopy: A Python Coding Exercise in Data Processing and Machine Learning

Samuel T. Cahill, Joseph E. B. Young, Max Howe, Ryan Clark, Andrew F. Worrall and Malcolm I. Stewart

J. Chem. Educ., 2024, 101, 2925
DOI: 10.1021/acs.jchemed.4c00295

Hyperspectral imaging for discrimination of Keemun black tea quality categories: Multivariate calibration analysis and data fusion

Guangxin Ren, Ying Liu, Jingming Ning and Zhengzhu Zhang

Int J of Food Sci Tech, 2021, 56, 2580
DOI: 10.1111/ijfs.14624

Precise diagnosis of small cell and non-small cell lung cancer based on Raman spectroscopy

Wendong Sun, Liwei Liao, Ruochen Zhu, Yuexiang Wang, Keren Chen, Gang Hou and Shuo Chen

Photodiagnosis and Photodynamic Therapy, 2025, 55, 104747
DOI: 10.1016/j.pdpdt.2025.104747

Label-free, rapid and highly accurate identification and categorization of leukemia cells via Raman spectroscopy

Luyue Jiang, Matthew Xinhu Ren, Gang Niu, Jingang Shi, Xinhao Cao, Yan Duan, Heping Wu, Zhen Xie, Yi Quan, Libo Zhao, Zhuangde Jiang, Yihong Gong, Wei Ren and Gang Zhao

Sensors and Actuators B: Chemical, 2023, 395, 134497
DOI: 10.1016/j.snb.2023.134497

Iodine excess induces hepatic, renal and pancreatic injury in female mice as determined by attenuated total reflection Fourier‐transform infrared spectrometry

Yang Guo, Chunhui Hu, Bintong Xia, Xianwen Zhou, Sihan Luo, Ruijia Gan, Peng Duan and Yan Tan

J of Applied Toxicology, 2022, 42, 600
DOI: 10.1002/jat.4242

Enhancing Diagnostic Reliability of Ex Vivo Adenocarcinoma Identification Using Minimally Processed, Heterogeneous Raman Spectra and Deep Learning

S. Kiran Koya, Michelle A. Brusatori, Sally Yurgelevic, Changhe Huang, Emma Velasco, Lekhana Katuri, Michael J. Simoff and Gregory W. Auner

J Raman Spectroscopy, 2026
DOI: 10.1002/jrs.70115

Raman Spectroscopy Assisted by Machine Learning Algorithms for the Prediction of Different Types of Oral Cancer Cells

Maria Lasalvia, Vito Capozzi and Giuseppe Perna

Applied Sciences, 2026, 16, 2380
DOI: 10.3390/app16052380

Raman Microspectral Study and Classification of the Pathological Evolution of Breast Cancer Using Both Principal Component Analysis-Linear Discriminant Analysis and Principal Component Analysis-Support Vector Machine

Heping Li, Yu Ren, Fan Yu, Dongliang Song, Lizhe Zhu, Shibo Yu, Siyuan Jiang, Shuang Wang and Alessandra Durazzo

Journal of Spectroscopy, 2021, 2021, 1
DOI: 10.1155/2021/5572782

Optical sensor for fast and accurate lung cancer detection with tissue autofluorescence and diffuse reflectance spectroscopy

Xianbei Yang, Anzhi Chen, Kaicheng U, Sophia Meixuan Zhang, Peihao Wang, Zheng Li, Yi Luo and Yong Cui

Thoracic Cancer, 2025, 16
DOI: 10.1111/1759-7714.15476