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Comparing the greenness and sustainability of three routes to an HIV protease inhibitor intermediate

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Highly efficient and fast synthesis of di-iodinated succinimide derivatives from 1,6-enyne and I2 under air at room temperature

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Green Chem., 2022, 24, 8021
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Synthesis of a spiroketone intermediate featuring a green and sustainable telescoped flow process

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Making chemicals from the air: the new frontier for hybrid electrosyntheses in artificial tree-like devices

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Green Chem., 2024, 26, 15
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Improving the environmental hazard scores metric for solvent mixtures containing carbon dioxide for chromatographic separations

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Green Chem., 2022, 24, 4504
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Bacterial cellulose-based functional yarns: from design to applications

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2D green SPPS: green solvents for on-resin removal of acid sensitive protecting groups and lactamization

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Green Chem., 2019, 21, 2594
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Protecting-group-free mechanosynthesis of amides from hydroxycarboxylic acids: application to the synthesis of imatinib

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The periodic table of the elements of green and sustainable chemistry

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Green Chem., 2019, 21, 6545
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A tutorial review for research laboratories to support the vital path toward inherently sustainable and green synthetic chemistry

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Why we might be misusing process mass intensity (PMI) and a methodology to apply it effectively as a discovery level metric

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Green Chem., 2020, 22, 123
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Making better decisions during synthetic route design: leveraging prediction to achieve greenness-by-design

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Cumulative complexity meta-metrics as an efficiency measure and predictor of process mass intensity (PMI) during synthetic route design

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Green Chem., 2023, 25, 5543
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Retrosynthesis from transforms to predictive sustainable chemistry and nanotechnology: a brief tutorial review

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Building bio-Profiles for common catalytic reactions

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Green Chem., 2021, 23, 6373
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A Review on Green Synthesis of Biologically Active Compounds

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CGC, 2022, 9, 174
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A pervasive study on Green Manufacturing towards attaining sustainability

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Accelerating Pharmaceutical Development via Metal‐Mediated Bond Formation

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Israel Journal of Chemistry, 2020, 60, 340
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Green Chemistry Metrics, A Review

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Large-Scale Amide Coupling in Aqueous Media: Process for the Production of Diazabicyclooctane β-Lactamase Inhibitors

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Manufacturing mass intensity: 15 Years of Process Mass Intensity and development of the metric into plant cleaning and beyond

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Current Research in Green and Sustainable Chemistry, 2022, 5, 100229
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Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production

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5‐Hydroxymethylfurfural and Furfural Chemistry Toward Biobased Surfactants

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ChemSusChem, 2022, 15
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Green Chemistry in the Synthesis of Pharmaceuticals

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Mechanochemistry Can Reduce Life Cycle Environmental Impacts of Manufacturing Active Pharmaceutical Ingredients

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ACS Sustainable Chem. Eng., 2022, 10, 1430
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Development of a Recycling Process for an Industrial-Scale Production of Tipifarnib

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Org. Process Res. Dev., 2021, 25, 1664
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Synthesis of Vixotrigine, a Voltage- and Use-Dependent Sodium Channel Blocker. Part 2: Development of a Late-Stage Process

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Org. Process Res. Dev., 2020, 24, 2814
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Assessing the Greenness of Mechanochemical Processes with the DOZN 2.0 Tool

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ACS Sustainable Chem. Eng., 2022, 10, 5110
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Improved iGAL 2.0 Metric Empowers Pharmaceutical Scientists to Make Meaningful Contributions to United Nations Sustainable Development Goal 12

Frank Roschangar, Jun Li, Yanyan Zhou, Wim Aelterman, Alina Borovika, Juan Colberg, David P. Dickson, Fabrice Gallou, John D. Hayler, Stefan G. Koenig, Michael E. Kopach, Birgit Kosjek, David K. Leahy, Erin O’Brien, Austin G. Smith, Manuel Henry, Jutta Cook and Roger A. Sheldon

ACS Sustainable Chem. Eng., 2022, 10, 5148
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Green and sustainable metrics: Charting the course for green-by-design small molecule API synthesis

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Current Research in Green and Sustainable Chemistry, 2022, 5, 100324
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One-Pot Tandem Oxidative Bromination and Amination of Sulfenamide for the Synthesis of Sulfinamidines

Gao-feng Yang, He-sen Huang, Xiao-kang Nie, Shi-qi Zhang, Xin Cui, Zhuo Tang and Guang-xun Li

J. Org. Chem., 2023, 88, 4581
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Recent advances in the synthesis of active pharmaceutical and agrochemical ingredients in micellar media

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Current Opinion in Green and Sustainable Chemistry, 2023, 39, 100729
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Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics

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Org. Process Res. Dev., 2024, 28, 2885
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Green metrics in pharmaceutical development

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Challenges in the development of new green solvents for polymer dissolution

Anna Zhenova

Polymer International, 2020, 69, 895
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Green Synthesis of Molecules for the Treatment of Neglected Diseases

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CTMC, 2023, 23, 1004
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Green metric tools for analytical methods assessment critical review, case studies and crucify

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Driving Aspirational Process Mass Intensity Using Simple Structure-Based Prediction

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Org. Process Res. Dev., 2022, 26, 1405
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Cradle-to-gate life cycle assessment of a liquid pharmaceutical product through analysis of chemical production pathways

Çağrı Emre Güneş and Hatice Şengül

Clean Techn Environ Policy, 2022, 24, 1741
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Cumulative Green Chemistry Principle Score for Objective Assessment of Drug Synthesis

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ACS Sustainable Chem. Eng., 2023, 11, 16144
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Defossilization of pharmaceutical manufacturing

Lea Wollensack, Kristi Budzinski and Jan Backmann

Current Opinion in Green and Sustainable Chemistry, 2022, 33, 100586
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Integrated Life Cycle and Techno-Economic Assessment of Micellar Solvent Systems in Bulk Fine Chemical Production

Johannes Wunderlich, Georg A. Buchner, Michael Schwarze and Reinhard Schomäcker

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Solvent-free K–CaO/Ca(OH)2 mixed-phase nanocatalytic single-step methanolysis, ethanolysis and aminolysis of Pongamia pinnata triglycerides

Dinesh Kumar, Chan Hee Park and Cheol Sang Kim

Sustainable Chemistry and Pharmacy, 2020, 18, 100317
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Is Micellar Catalysis Green Chemistry?

Fabrizio Fabris, Markus Illner, Jens-Uwe Repke, Alessandro Scarso and Michael Schwarze

Molecules, 2023, 28, 4809
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Carbon footprint modelling of national health systems: Opportunities, challenges and recommendations

Amy Booth

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The chronological evolution of environment benign processes in the synthesis of natural products and APIs

Geetmani Singh Nongthombam, Abhipsha Saikia and Jagat Chandra Borah

Sustainable Chemistry and Pharmacy, 2024, 41, 101725
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Using Data Analysis To Evaluate and Compare Chemical Syntheses

Dustin Kaiser, Jianbo Yang and Georg Wuitschik

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Sustainable synthesis of melitracen HCl and its key intermediate, 10,10-Dimethylanthrone: A green solvent-driven and economically efficient approach with comprehensive sustainability analysis using iGAL 2.0

Dinesh Krishna Narukulla and Venkata Rao Kaki

Journal of the Indian Chemical Society, 2025, 102, 102067
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Evaluating Molecular Complexity with Open-Source Machine Learning Approaches to Predict Process Mass Intensity

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ACS Omega, 2024, 9, 28476
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Pd-Catalyzed C(sp2)–H/C(sp2)–H Coupling of Limonene

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J. Org. Chem., 2024, 89, 10451
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Shaping Effective Practices for Incorporating Sustainability Assessment in Manuscripts Submitted to ACS Sustainable Chemistry & Engineering: Catalysis and Catalytic Processes

Damien P. Debecker, King Kuok (Mimi) Hii, Audrey Moores, Liane M. Rossi, Bert Sels, David T. Allen and Bala Subramaniam

ACS Sustainable Chem. Eng., 2021, 9, 4936
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A Green Chemistry Continuum for a Robust and Sustainable Active Pharmaceutical Ingredient Supply Chain

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ACS Sustainable Chem. Eng., 2019, 7, 16937
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High-Yield Synthesis of 1-Hydroxyhexane-2,5-dione via Hydrogenation/Hydrolysis of 5-Hydroxymethyl-furfural in Ionic Liquid-Assisted Multi-Phase Systems

Daniele Polidoro, Irina Elena Mihai, Alvise Perosa and Maurizio Selva

ACS Sustainable Chem. Eng., 2023, 11, 2520
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Recent Highlights in Micellar Catalysis: An Industrial Outlook

Tharique N. Ansari, Guolin Xu, Andrew Preston and Peng Gao

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Development of Robust, Efficient and Scalable Transition Metal Catalyzed Transformations: Translation of Reactions from Micromole to Multi-Kilogram Scale Processes

Jacob M. Ganley, Candice L. Joe and Eric M. Simmons

ACS Catal., 2025, 15, 8317
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Advantages and drawbacks of life cycle assessment application to the pharmaceuticals: a short critical literature review

Marco Satta, Fabrizio Passarini, Daniele Cespi and Luca Ciacci

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Ideality in Context: Motivations for Total Synthesis

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Environmental Sustainability Strategy of Active Pharmaceutical Ingredient Manufacturing: A Perspective from the American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable

Juan Colberg, John L. Tucker, Isamir Martínez, J. Daniel Bailey, Christiana Briddell, Stefan G. Koenig, Michael E. Kopach, Sharon Michalak, Astrid Parsons, Paul F. Richardson, Frank Roschangar, Eva Vestergaard and Adelina Voutchkova-Kostal

ACS Sustainable Chem. Eng., 2025, 13, 10268
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Nanoconfinement Effects of Micellar Media in Asymmetric Catalysis

Tommaso Lorenzetto, Davide Frigatti, Fabrizio Fabris and Alessandro Scarso

Adv Synth Catal, 2022, 364, 1776
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“The hidden power and competitive advantage of applying green chemistry metrics”

John L. Tucker

Current Opinion in Green and Sustainable Chemistry, 2022, 35, 100606
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Catalytic Base‐Free Transfer Hydrogenation of Biomass Derived Furanic Aldehydes with Bioalcohols and PNP Pincer Complexes

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Solubility Modeling for Key Organic Compounds Used in Adavosertib (Anticancer API) Manufacturing

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ACS Omega, 2025, 10, 27964
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Bridging Lab and Industry with Flow Electrochemistry

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iScience, 2020, 23, 101720
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On an intensification factor for green chemistry and engineering: The value of an operationally simple decision-making tool in process assessment

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Sustainable Chemistry and Pharmacy, 2022, 27, 100651
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Solvent Eco-Impact Metric: A Tool for Chemists to Drive Sustainability in Chemical Processes across Safety, Health, Waste, and Environmental Aspects

Marco Ferrara, Federico Della Negra and Massimo Verzini

Org. Process Res. Dev., 2025, 29, 1110
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Challenges and Achievements of Peptide Synthesis in Aqueous and Micellar Media

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ChemBioChem, 2025, 26
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The PMI Predictor app to enable green-by-design chemical synthesis

Alina Borovika, Jacob Albrecht, Jun Li, Andrew S. Wells, Christiana Briddell, Barry R. Dillon, Louis J. Diorazio, James R. Gage, Fabrice Gallou, Stefan G. Koenig, Michael E. Kopach, David K. Leahy, Isamir Martinez, Martin Olbrich, Jared L. Piper, Frank Roschangar, Edward C. Sherer and Martin D. Eastgate

Nat Sustain, 2019, 2, 1034
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Water-Tuned Tautomer-Selective Tandem Synthesis of the 5,6-Dihydropyrimidin-4(3H)-ones, Driven under the Umbrella of Sustainable Chemistry

Nenad Janković, Srđan Stefanović, Jelena Petronijević, Nenad Joksimović, Slađana B. Novaković, Goran A. Bogdanović, Jovana Muškinja, Milan Vraneš, Zoran Ratković and Zorica Bugarčić

ACS Sustainable Chem. Eng., 2018, 6, 13358
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