Inhibitory effect of selected Indian honey on colon cancer cell growth by inducing apoptosis and targeting the β-catenin/Wnt pathway

Neeladrisingha Das, Neelanjana Ray, Abhinandan R. Patil, Shashank Sagar Saini, Bhairavnath Waghmode, Chandrachur Ghosh, Sunita B. Patil, Sandeep B. Patil, Chandrasekhar S. Mote, Surendra Saini, B. L. Saraswat, Debabrata Sircar and Partha Roy

Food Funct., 2022, 13, 8283
DOI: 10.1039/D1FO03727G

Physicochemical and Rheological Characteristics of Monofloral Honeys—Kinetics of Creaming–Crystallization

Kerasia Polatidou, Chrysanthi Nouska, Chrysoula Tananaki, Costas G. Biliaderis and Athina Lazaridou

Foods, 2025, 14, 1835
DOI: 10.3390/foods14101835

Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation

Massimiliano Gasparrini, Sadia Afrin, Tamara Y. Forbes-Hernández, Danila Cianciosi, Patricia Reboredo-Rodriguez, Adolfo Amici, Maurizio Battino and Francesca Giampieri

Food and Chemical Toxicology, 2018, 120, 578
DOI: 10.1016/j.fct.2018.08.001

Strawberry tree honey as a new potential functional food. Part 1: Strawberry tree honey reduces colon cancer cell proliferation and colony formation ability, inhibits cell cycle and promotes apoptosis by regulating EGFR and MAPKs signaling pathways

Sadia Afrin, Francesca Giampieri, Danila Cianciosi, Francesca Pistollato, Johura Ansary, Mattia Pacetti, Adolfo Amici, Patricia Reboredo-Rodríguez, Jesus Simal-Gandara, Josè L. Quiles, Tamara Y. Forbes-Hernández and Maurizio Battino

Journal of Functional Foods, 2019, 57, 439
DOI: 10.1016/j.jff.2019.04.035

Comparative study of the protective and therapeutic effects of Manuka and Saudi Sidr honey on experimentally induced gastric ulcer in rats

Reem Alazragi, Ghadeer Al-Ghamdi and Rasha H. Hussein

Materials Today: Proceedings, 2023, 81, 612
DOI: 10.1016/j.matpr.2021.04.069

Neferine and isoliensinine enhance ‘intracellular uptake of cisplatin’ and induce ‘ROS-mediated apoptosis’ in colorectal cancer cells – A comparative study

Prasath Manogaran, Narasimha Murthy Beeraka, Chih-Yang Huang and Viswanadha Vijaya Padma

Food and Chemical Toxicology, 2019, 132, 110652
DOI: 10.1016/j.fct.2019.110652

5-Hydroxymethyl-Furfural and Structurally Related Compounds Block the Ion Conductance in Human Aquaporin-1 Channels and Slow Cancer Cell Migration and Invasion

Pak Hin Chow, Mohamad Kourghi, Jinxin V. Pei, Saeed Nourmohammadi and Andrea J. Yool

Molecular Pharmacology, 2020, 98, 38
DOI: 10.1124/mol.119.119172

Natural products targeting glycolysis in cancer

Yuanyuan Zhao, Louisa S Chard Dunmall, Zhenguo Cheng, Yaohe Wang and Lingling Si

Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.1036502

Beeswax by-Products Efficiently Counteract the Oxidative Damage Induced by an Oxidant Agent in Human Dermal Fibroblasts

Francesca Giampieri, Massimiliano Gasparrini, Tamara Y. Forbes-Hernández, Piera Pia Manna, Jiaojiao Zhang, Patricia Reboredo-Rodríguez, Danila Cianciosi, Jose L. Quiles, Cristina Torres Fernández-Piñar, Francisco Josè Orantes-Bermejo, Stefano Bompadre, Sadia Afrin and Maurizio Battino

IJMS, 2018, 19, 2842
DOI: 10.3390/ijms19092842

An updated review of functional ingredients of Manuka honey and their value-added innovations

Sunan Wang, Yi Qiu and Fan Zhu

Food Chemistry, 2024, 440, 138060
DOI: 10.1016/j.foodchem.2023.138060

Comparison of the Chemical Composition and Biological Activity of Mature and Immature Honey: An HPLC/QTOF/MS-Based Metabolomic Approach

Nana Guo, Liuwei Zhao, Yazhou Zhao, Qiangqiang Li, Xiaofeng Xue, Liming Wu, Margarita Gomez Escalada, Kai Wang and Wenjun Peng

J. Agric. Food Chem., 2020, 68, 4062
DOI: 10.1021/acs.jafc.9b07604

Identification of syrup adulteration in wolfberry honey using CNN-CBAM-SVM combined with 1H NMR

Shengkang Ji, Shengyu Hao, Jichun Cui, Jie Yuan and Hongzhuan Xuan

Food Chemistry, 2025, 493, 145728
DOI: 10.1016/j.foodchem.2025.145728

Relevance of functional foods in the Mediterranean diet: the role of olive oil, berries and honey in the prevention of cancer and cardiovascular diseases

Maurizio Battino, Tamara Y. Forbes-Hernández, Massimiliano Gasparrini, Sadia Afrin, Danila Cianciosi, Jiaojiao Zhang, Piera P. Manna, Patricia Reboredo-Rodríguez, Alfonso Varela Lopez, Josè L. Quiles, Bruno Mezzetti, Stefano Bompadre, Jianbo Xiao and Francesca Giampieri

Critical Reviews in Food Science and Nutrition, 2019, 59, 893
DOI: 10.1080/10408398.2018.1526165

In silico Approach of Some Selected Manuka Honey Constituents as Epstein–Barr Virus (EBV) Nuclear Antigen 1 (EBNA1) Inhibitors

Achmad Chusnu Romdhoni and Mohd Razif Mohamad Yunus

Biomolecular and Health Science Journal, 2023, 6, 111
DOI: 10.4103/bhsj.bhsj_13_23

Manuka honey, a unique mono-floral honey. A comprehensive review of its bioactives, metabolism, action mechanisms, and therapeutic merits

Fardous F. El-Senduny, Nesrine M. Hegazi, Ghada E. Abd Elghani and Mohamed A. Farag

Food Bioscience, 2021, 42, 101038
DOI: 10.1016/j.fbio.2021.101038

Bioactive compounds in Apis mellifera monofloral honeys

Rafael Viteri, Flavia Zacconi, Gloria Montenegro and Ady Giordano

Journal of Food Science, 2021, 86, 1552
DOI: 10.1111/1750-3841.15706

Controlling metastatic cancer: the role of phytochemicals in cell signaling

Andrea Kapinova, Peter Kubatka, Alena Liskova, Denis Baranenko, Peter Kruzliak, Milan Matta, Dietrich Büsselberg, Bibiana Malicherova, Anthony Zulli, Taeg Kyu Kwon, Eva Jezkova, Dana Blahutova, Pavol Zubor and Jan Danko

J Cancer Res Clin Oncol, 2019, 145, 1087
DOI: 10.1007/s00432-019-02892-5

Therapeutic and preventive properties of honey and its bioactive compounds in cancer: an evidence-based review

Sadia Afrin, Shoja M. Haneefa, Maria J. Fernandez-Cabezudo, Francesca Giampieri, Basel K. al-Ramadi and Maurizio Battino

Nutr. Res. Rev., 2020, 33, 50
DOI: 10.1017/S0954422419000192

The Influence of In Vitro Gastrointestinal Digestion on the Anticancer Activity of Manuka Honey

Danila Cianciosi, Tamara Yuliett Forbes-Hernández, Sadia Afrin, Massimiliano Gasparrini, José L. Quiles, Emilio Gil, Stefano Bompadre, Jesus Simal-Gandara, Maurizio Battino and Francesca Giampieri

Antioxidants, 2020, 9, 64
DOI: 10.3390/antiox9010064

The Development and Application of a HPTLC-Derived Database for the Identification of Phenolics in Honey

Ivan Lozada Lawag, Tomislav Sostaric, Lee Yong Lim, Katherine Hammer and Cornelia Locher

Molecules, 2022, 27, 6651
DOI: 10.3390/molecules27196651

SIRT1: a novel regulator in colorectal cancer

Weiwei Dong, Jinjing Lu, You Li, Juan Zeng, Xiaoyun Du, Ao Yu, Xuechan Zhao, Feng Chi, Zhuo Xi and Shuo Cao

Biomedicine & Pharmacotherapy, 2024, 178, 117176
DOI: 10.1016/j.biopha.2024.117176

Honey Polyphenols Ameliorate DSS‐Induced Ulcerative Colitis via Modulating Gut Microbiota in Rats

Haoan Zhao, Ni Cheng, Wenqi Zhou, Sinan Chen, Qian Wang, Hui Gao, Xiaofeng Xue, Liming Wu and Wei Cao

Molecular Nutrition Food Res, 2019, 63
DOI: 10.1002/mnfr.201900638

From metabolism to malignancy: the multifaceted role of PGC1α in cancer

Yue Wang, Jianing Peng, Dengyuan Yang, Zhongjie Xing, Bo Jiang, Xu Ding, Chaoyu Jiang, Bing Ouyang and Lei Su

Front. Oncol., 2024, 14
DOI: 10.3389/fonc.2024.1383809

Ultra-Small Iron Nanoparticles Target Mitochondria Inducing Autophagy, Acting on Mitochondrial DNA and Reducing Respiration

Lorenzo Rivas-García, José Luis Quiles, Alfonso Varela-López, Francesca Giampieri, Maurizio Battino, Jörg Bettmer, María Montes-Bayón, Juan Llopis and Cristina Sánchez-González

Pharmaceutics, 2021, 13, 90
DOI: 10.3390/pharmaceutics13010090

Effects of Sangju Honey on Oral Squamous Carcinoma Cells

Nangwon Yee, Hyeonjin Kim, Eungyung Kim, Yong Ho Cha, Lei Ma, Na Eun Cho, Dongwook Kim, Chae Yeon Kim, Sung-Hyun Kim, Zaeyoung Ryoo, Junkoo Yi and Myoung Ok Kim

J Cancer Prev, 2022, 27, 239
DOI: 10.15430/JCP.2022.27.4.239

Physicochemical Characteristics and Bioactive Compounds of Different Types of Honey and Their Biological and Therapeutic Properties: A Comprehensive Review

Mohammad A. Al-Kafaween, Mohammad Alwahsh, Abu Bakar Mohd Hilmi and Dina H. Abulebdah

Antibiotics, 2023, 12, 337
DOI: 10.3390/antibiotics12020337

Strawberry tree honey as a new potential functional food. Part 2: Strawberry tree honey increases ROS generation by suppressing Nrf2-ARE and NF-кB signaling pathways and decreases metabolic phenotypes and metastatic activity in colon cancer cells

Sadia Afrin, Tamara Y. Forbes-Hernández, Danila Cianciosi, Francesca Pistollato, JiaoJiao Zhang, Mattia Pacetti, Adolfo Amici, Patricia Reboredo-Rodríguez, Jesus Simal-Gandara, Stefano Bompadre, Josè L. Quiles, Francesca Giampieri and Maurizio Battino

Journal of Functional Foods, 2019, 57, 477
DOI: 10.1016/j.jff.2019.04.037

Quality Assessment and Bioactive Component Analysis of Honey from Different Geographical Regions in Erzurum, Türkiye

Adem Savaş, Halil İbrahim Binici, İhsan Güngör Şat and Mustafa Kiliç

Akademik Gıda, 2024, 22, 215
DOI: 10.24323/akademik-gida.1603870

Antiproliferative effects of bioaccessible fractions of honeys from Sicilian black honeybee (Apis mellifera ssp. sicula) on human colorectal carcinoma cells

Antonio Cilla, Gabriel López‐García, Reyes Barberá, Anna Frazzitta, Ignazio Restivo, Luisa Tesoriere and Alessandro Attanzio

Int J of Food Sci Tech, 2022, 57, 2636
DOI: 10.1111/ijfs.15169

Honey with added value – enriched with rutin and quercetin from Sophora flower

Sofija Đorđević, Nebojša Nedić, Aleksandra Pavlović, Dušanka Milojković-Opsenica, Živoslav Tešić and Uroš Gašić

Journal of Herbal Medicine, 2022, 34, 100580
DOI: 10.1016/j.hermed.2022.100580

Anti-Tumor Activity of Hypericum perforatum L. and Hyperforin through Modulation of Inflammatory Signaling, ROS Generation and Proton Dynamics

Marta Menegazzi, Pellegrino Masiello and Michela Novelli

Antioxidants, 2020, 10, 18
DOI: 10.3390/antiox10010018

Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 1: Enhancement of cellular viability, regulation of cellular apoptosis and improvement of mitochondrial functionality

Sadia Afrin, Massimiliano Gasparrini, Tamara Y. Forbes-Hernández, Danila Cianciosi, Patricia Reboredo-Rodriguez, Piera Pia Manna, Maurizio Battino and Francesca Giampieri

Food and Chemical Toxicology, 2018, 121, 203
DOI: 10.1016/j.fct.2018.09.001

Hawthorn Proanthocyanidin Extract Inhibits Colorectal Carcinoma Metastasis by Targeting the Epithelial-Mesenchymal Transition Process and Wnt/β-Catenin Signaling Pathway

Ziwei Wang, Yasai Sun, Mengying Wu, Liangfu Zhou, Yu Zheng, Ting Ren, Meijiao Li and Wen Zhao

Foods, 2024, 13, 1171
DOI: 10.3390/foods13081171

The role of SIRT1 in the development of gastrointestinal tumors

Yueming Zhang, Xiaokai Zhou, Jinghui Zhai, Jie Ma and Sixi Zhang

Front. Cell Dev. Biol., 2025, 13
DOI: 10.3389/fcell.2025.1606530

Composition, functional properties and safety of honey: a review

Hong Wang, Lantao Li, Xiaohui Lin, Weidong Bai, Gengsheng Xiao and Gongliang Liu

J Sci Food Agric, 2023, 103, 6767
DOI: 10.1002/jsfa.12720

Reductive Stress, Bioactive Compounds, Redox-Active Metals, and Dormant Tumor Cell Biology to Develop Redox-Based Tools for the Treatment of Cancer

José L. Quiles, Cristina Sánchez-González, Laura Vera-Ramírez, Francesca Giampieri, M. Dolores Navarro-Hortal, Jianbo Xiao, Juan Llopis, Maurizio Battino and Alfonso Varela-López

Antioxidants & Redox Signaling, 2020, 33, 860
DOI: 10.1089/ars.2020.8051

Therapeutic properties of some specific honey types

Marijana Sakač, Pavle Jovanov, Aleksandar Marić, Dragana Plavšić, Dimitar Jakimov and Branislava Đermanović

Food & Feed Res, 2025, 52, 67
DOI: 10.5937/ffr0-53050

Bee Products and Colorectal Cancer—Active Components and Mechanism of Action

Justyna Moskwa, Sylwia Katarzyna Naliwajko, Dominika Dobiecka and Katarzyna Socha

Nutrients, 2023, 15, 1614
DOI: 10.3390/nu15071614