Machine learning-aided quantification of antibody-based cancer immunotherapy by natural killer cells in microfluidic droplets

Saheli Sarkar, Wenjing Kang, Songyao Jiang, Kunpeng Li, Somak Ray, Ed Luther, Alexander R. Ivanov, Yun Fu and Tania Konry

Lab Chip, 2020, 20, 2317
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Haimeng Pei, Mei Yu, Defang Dong, Yiguo Wang, Qingling Li, Lu Li and Bo Tang

Chem. Sci., 2020, 11, 8895
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Ensemble latent assimilation with deep learning surrogate model: application to drop interaction in a microfluidics device

Yilin Zhuang, Sibo Cheng, Nina Kovalchuk, Mark Simmons, Omar K. Matar, Yi-Ke Guo and Rossella Arcucci

Lab Chip, 2022, 22, 3187
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Droplet microfluidics for functional temporal analysis and cell recovery on demand using microvalves: application in immunotherapies for cancer

Sagar N. Agnihotri, Giovanni Stefano Ugolini, Matthew Ryan Sullivan, Yichao Yang, Agustin De Ganzó, Ji Won Lim and Tania Konry

Lab Chip, 2022, 22, 3258
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Inverse micelle mediated calcium chloride transportation for facile alginate gelation in microdroplets

Fuyang Qu, Luoquan Li, Qinru Xiao and Yi-Ping Ho

Lab Chip, 2025, 25, 4588
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Single-cell droplet microfluidics for biomedical applications

Dan Liu, Meilin Sun, Jinwei Zhang, Rui Hu, Wenzhu Fu, Tingting Xuanyuan and Wenming Liu

Analyst, 2022, 147, 2294
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Static droplet array for culturing single live adherent cells in an isolated chemical microenvironment

Amin Hassanzadeh-Barforoushi, Andrew M. K. Law, Abbas Hejri, Mohsen Asadnia, Christopher J. Ormandy, David Gallego-Ortega and Majid Ebrahimi Warkiani

Lab Chip, 2018, 18, 2156
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Construction of single-cell arrays and assay of cell drug resistance in an integrated microfluidic platform

Long Pang, Wenming Liu, Chang Tian, Juan Xu, Tianbao Li, Shu-Wei Chen and Jinyi Wang

Lab Chip, 2016, 16, 4612
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Microdroplet chain array for cell migration assays

Yan Ma, Jian-Zhang Pan, Shi-Ping Zhao, Qi Lou, Ying Zhu and Qun Fang

Lab Chip, 2016, 16, 4658
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Cell Culture in Microfluidic Droplets

Sébastien Sart, Gustave Ronteix, Shreyansh Jain, Gabriel Amselem and Charles N. Baroud

Chem. Rev., 2022, 122, 7061
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Fluid rheology prediction using interface detection and machine learning regression

Alexandra Bran and Corneliu Balan

Physics of Fluids, 2025, 37
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On-chip anticancer drug screening – Recent progress in microfluidic platforms to address challenges in chemotherapy

Nandini Dhiman, Peter Kingshott, Huseyin Sumer, Chandra S. Sharma and Subha Narayan Rath

Biosensors and Bioelectronics, 2019, 137, 236
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Microfluidic-based platforms for cell-to-cell communication studies

Lvyang Zhu, Qu Tang, Zhenzhen Mao, Huanhuan Chen, Li Wu and Yuling Qin

Biofabrication, 2024, 16, 012005
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Detection of Small Subsets of CD4+ Lymphocytes with SmartFlare Nanoprobes

A. P. Toptygina, R. Sh. Zakirov, K. S. Kapitanova and E. L. Semikina

Bull Exp Biol Med, 2019, 168, 270
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Dynamic analysis of immune and cancer cell interactions at single cell level in microfluidic droplets

S. Sarkar, P. Sabhachandani, D. Stroopinsky, K. Palmer, N. Cohen, J. Rosenblatt, D. Avigan and T. Konry

Biomicrofluidics, 2016, 10
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Microdroplets-on-chip: A review

Aihui Wang, Aynur Abdulla and Xianting Ding

Proc Inst Mech Eng H, 2019, 233, 683
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A droplet‐merging platform for comparative functional analysis of m1 and m2 macrophages in response to e. coli‐induced stimuli

Evangelia Hondroulis, Alexandru Movila, Pooja Sabhachandani, Saheli Sarkar, Noa Cohen, Toshihisa Kawai and Tania Konry

Biotech & Bioengineering, 2017, 114, 705
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Microfluidic cell isolation technology for drug testing of single tumor cells and their clusters

Swastika S. Bithi and Siva A. Vanapalli

Sci Rep, 2017, 7
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Innovative Tools and Technology for Analysis of Single Cells and Cell–Cell Interaction

Tania Konry, Saheli Sarkar, Pooja Sabhachandani and Noa Cohen

Annu. Rev. Biomed. Eng., 2016, 18, 259
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Droplet-based microtumor model to assess cell-ECM interactions and drug resistance of gastric cancer cells

Minjeong Jang, Ilkyoo Koh, Seok Jae Lee, Jae-Ho Cheong and Pilnam Kim

Sci Rep, 2017, 7
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Microfluidic technology for multiple single-cell capture

Cheng-Kun He and Chia-Hsien Hsu

Biomicrofluidics, 2021, 15
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Interrogation of single-cell communications on microfluidic platforms

Lu Huang, Yin Chen and Jianhua Zhou

Cell Reports Physical Science, 2022, 3, 101129
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Dynamic Analysis of Human Natural Killer Cell Response at Single-Cell Resolution in B-Cell Non-Hodgkin Lymphoma

Saheli Sarkar, Pooja Sabhachandani, Dashnamoorthy Ravi, Sayalee Potdar, Sneha Purvey, Afshin Beheshti, Andrew M. Evens and Tania Konry

Front. Immunol., 2017, 8
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Microfluidic Devices for Drug Delivery Systems and Drug Screening

Samar Damiati, Uday B. Kompella, Safa A. Damiati and Rimantas Kodzius

Genes, 2018, 9, 103
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Application of microfluidic chip technology in pharmaceutical analysis: A review

Ping Cui and Sicen Wang

Journal of Pharmaceutical Analysis, 2019, 9, 238
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Nanoliter-Scale Droplet–Droplet Microfluidic Microextraction Coupled with MALDI-TOF Mass Spectrometry for Metabolite Analysis of Cell Droplets

Wen-Hua Sun, Yan Wei, Xiao-Li Guo, Qiong Wu, Xin Di and Qun Fang

Anal. Chem., 2020, 92, 8759
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Microengineered 3D Tumor Models for Anti-Cancer Drug Discovery in Female-Related Cancers

Farbod Amirghasemi, Emmanuela Adjei-Sowah, Barbara A. Pockaj and Mehdi Nikkhah

Ann Biomed Eng, 2021, 49, 1943
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Coupling Microfluidic Platforms, Microfabrication, and Tissue Engineered Scaffolds to Investigate Tumor Cells Mechanobiology

Martial Millet, Raoua Ben Messaoud, Carole Luthold and Francois Bordeleau

Micromachines, 2019, 10, 418
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The Convergence of Artificial Intelligence and Microfluidics in Drug Research and Development

Du Qiao, Hongxia Li, Xue Zhang, Xuhui Chen, Jiang Zhang, Jianan Zou, Danyang Zhao, Weiping Zhu, Xuhong Qian and Honglin Li

Engineering, 2025
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Application of Microfluidics in Drug Development from Traditional Medicine

Xue Li, Xiaoming Fan, Zhu Li, Lina Shi, Jinkuan Liu, Hongzhi Luo, Lijun Wang, Xiaoxin Du, Wenzhu Chen, Jiuchuan Guo, Chenzhong Li and Shan Liu

Biosensors, 2022, 12, 870
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Recent advances in microfluidic platforms for single-cell analysis in cancer biology, diagnosis and therapy

Hamed Tavakoli, Wan Zhou, Lei Ma, Stefani Perez, Andrea Ibarra, Feng Xu, Sihui Zhan and XiuJun Li

TrAC Trends in Analytical Chemistry, 2019, 117, 13
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On the synergy of biomicrofluidic technologies and real-time 3D tracking: A perspective

Liu Hong and Leonardo P. Chamorro

Biomicrofluidics, 2023, 17
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Integrated microfluidic platform for rapid antimicrobial susceptibility testing and bacterial growth analysis using bead-based biosensor via fluorescence imaging

Pooja Sabhachandani, Saheli Sarkar, Paola C. Zucchi, Betsy A. Whitfield, James E. Kirby, Elizabeth B. Hirsch and Tania Konry

Microchim Acta, 2017, 184, 4619
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Dendronized fluorosurfactant for highly stable water-in-fluorinated oil emulsions with minimal inter-droplet transfer of small molecules

Mohammad Suman Chowdhury, Wenshan Zheng, Shalini Kumari, John Heyman, Xingcai Zhang, Pradip Dey, David A. Weitz and Rainer Haag

Nat Commun, 2019, 10
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Acoustofluidic Droplet Sorter Based on Single Phase Focused Transducers

Ruoyu Zhong, Shujie Yang, Giovanni Stefano Ugolini, Ty Naquin, Jinxin Zhang, Kaichun Yang, Jianping Xia, Tania Konry and Tony Jun Huang

Small, 2021, 17
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Machine learning phenomics (MLP) combining deep learning with time-lapse-microscopy for monitoring colorectal adenocarcinoma cells gene expression and drug-response

M. D’Orazio, M. Murdocca, A. Mencattini, P. Casti, J. Filippi, G. Antonelli, D. Di Giuseppe, M. C. Comes, C. Di Natale, F. Sangiuolo and E. Martinelli

Sci Rep, 2022, 12
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Review of the role of surfactant dynamics in drop microfluidics

Nina M. Kovalchuk and Mark J.H. Simmons

Advances in Colloid and Interface Science, 2023, 312, 102844
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Inkjet‐Patterned Microdroplets as Individual Microenvironments for Adherent Single Cell Culture

Tianze Xie, Qiang Zhang, Weifei Zhang, Shuo Feng and Jin‐Ming Lin

Small, 2022, 18
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Investigation of Different Free Image Analysis Software for High-Throughput Droplet Detection

Immanuel Sanka, Simona Bartkova, Pille Pata, Olli-Pekka Smolander and Ott Scheler

ACS Omega, 2021, 6, 22625
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Parallel probing of drug uptake of single cancer cells on a microfluidic device

Yoonsun Yang, Séverine Le Gac, Leon WMM Terstappen and Hoon Suk Rho

Electrophoresis, 2018, 39, 548
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3D imaging of moving cells within droplets with a staggered bifocal microlens array

Xinglong Huang, Yingzhe Piao, Jiayan Zhuang, Chunhui Wu, Dongrui Zhang, Xing Cheng and Boris Stoeber

Opt. Express, 2025, 33, 26152
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A Microfluidic Strategy for Controllable Generation of Water‐in‐Water Droplets as Biocompatible Microcarriers

Hai‐Tao Liu, Hui Wang, Wen‐Bo Wei, Hui Liu, Lei Jiang and Jian‐Hua Qin

Small, 2018, 14
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Advances in Microtechnology for Improved Cytotoxicity Assessment

Maite Garcia-Hernando, Fernando Benito-Lopez and Lourdes Basabe-Desmonts

Front. Mater., 2020, 7
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Droplet-based microfluidics: an efficient high-throughput portable system for cell encapsulation

Hengameh Dortaj, Ali Mohammad Amani, Lobat Tayebi, Negar Azarpira, Mahtab Ghasemi Toudeshkchouei, Ashraf Hassanpour-Dehnavi, Neda Karami, Milad Abbasi, Atefeh Najafian-Najafabadi, Zeinab Zarei Behjani and Ahmad Vaez

Journal of Microencapsulation, 2024, 41, 479
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Application of Microfluidic Systems for Breast Cancer Research

Zachary D. Frankman, Linan Jiang, Joyce A. Schroeder and Yitshak Zohar

Micromachines, 2022, 13, 152
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Interface Dynamics and the Influence of Gravity on Droplet Generation in a Y-microchannel

Alexandra Bran, Nicoleta Tanase and Corneliu Balan

Micromachines, 2022, 13, 1941
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An innovative single-cell approach for phenotyping and functional genotyping of CAR NK cells

Matthew Ryan Sullivan, Michael Finocchiaro, Yichao Yang, Judene Thomas, Alaa Ali, Isabel Kaplan, Yasmin Abdulhamid, Eden Bobilev, Michal Sheffer, Rizwan Romee and Tania Konry

J Immunother Cancer, 2024, 12, e008912
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Innovations in cancer treatment: evaluating drug resistance with lab-on-a-chip technologies

Parisa Heydari, Pouya Javaherchi, Meisam Samadzadeh, Reyhaneh Nasr Azadani, Alireza Bahrami Rad, Atefeh Zarepour, Arezoo Khosravi, Siavash Iravani and Ali Zarrabi

International Journal of Pharmaceutics, 2025, 682, 125936
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