Assessing inter- and intramolecular continuous-flow strategies towards methylphenidate (Ritalin) hydrochloride

Romaric Gérardy, Marc Winter, Alessandra Vizza and Jean-Christophe M. Monbaliu

React. Chem. Eng., 2017, 2, 149
DOI: 10.1039/C6RE00184J

Stereoselective synthesis of 2,3,4-highly substituted oxetanes by intramolecular C–C bond forming Michael addition

Guo-Ming Ho and Yu-Jang Li

Chem. Commun., 2016, 52, 12108
DOI: 10.1039/C6CC06857J

Synthesis of oxetane and azetidine ethers as ester isosteres by Brønsted acid catalysed alkylation of alcohols with 3-aryl-oxetanols and 3-aryl-azetidinols

Peerawat Saejong, Juan J. Rojas, Camille Denis, Andrew J. P. White, Anne Sophie Voisin-Chiret, Chulho Choi and James A. Bull

Org. Biomol. Chem., 2023, 21, 5553
DOI: 10.1039/D3OB00731F

Synthesis of seven-membered heterocycles via copper-catalyzed cross-coupling of terminal alkynes with diazo compounds and sequential Michael addition

Shenghu Yan, Shengyu Cao and Jiangtao Sun

Org. Biomol. Chem., 2017, 15, 5272
DOI: 10.1039/C7OB01091E

A controlled selective synthesis of dihydropyrans through tandem reaction of alkynes with diazo compounds

Junxiang Min, Guangyang Xu and Jiangtao Sun

Chem. Commun., 2017, 53, 4350
DOI: 10.1039/C7CC01616F

Facile synthesis of 1,4-oxazines by ruthenium-catalyzed tandem N–H insertion/cyclization of α-arylamino ketones and diazo pyruvates

Farrukh Sajjad, Yanmei Chen, Xue Tian, Suzhen Dong, Alavala Gopi Krishna Reddy, Wenhao Hu and Dong Xing

Org. Biomol. Chem., 2021, 19, 1769
DOI: 10.1039/D0OB01913E

Recent strategies used in the synthesis of saturated four-membered heterocycles

Kien P. Malarney, Shekhar KC and Valerie A. Schmidt

Org. Biomol. Chem., 2021, 19, 8425
DOI: 10.1039/D1OB00988E

(Z)-selective methoxy group-embedded Weinreb amide-type Horner–Wadsworth–Emmons reaction promoted by magnesium cation

Takatsugu Murata, Daiki Usukura, Hisazumi Tsutsui and Isamu Shiina

Chemistry Letters, 2025, 54
DOI: 10.1093/chemle/upaf119

Catalytic Asymmetric Diarylphosphine Addition to α-Diazoesters for the Synthesis of P-Stereogenic Phosphinates via P*—N Bond Formation

László B. Balázs, Yinhua Huang, Jasmina B. Khalikuzzaman, Yongxin Li, Sumod A. Pullarkat and Pak-Hing Leung

J. Org. Chem., 2020, 85, 14763
DOI: 10.1021/acs.joc.0c00181

Synthesis of Spirooxindole Oxetanes Through a Domino Reaction of 3‐Hydroxyoxindoles and Phenyl Vinyl Selenone

Martina Palomba, Elisabetta Scarcella, Luca Sancineto, Luana Bagnoli, Claudio Santi and Francesca Marini

Eur J Org Chem, 2019, 2019, 5396
DOI: 10.1002/ejoc.201900499

Evaluating New Chemistry to Drive Molecular Discovery: Fit for Purpose?

Daniel J. Foley, Adam Nelson and Stephen P. Marsden

Angew Chem Int Ed, 2016, 55, 13650
DOI: 10.1002/anie.201604193

Structurally Divergent Lithium Catalyzed Friedel–Crafts Reactions on Oxetan‐3‐ols: Synthesis of 3,3‐Diaryloxetanes and 2,3‐Dihydrobenzofurans

Rosemary A. Croft, James J. Mousseau, Chulho Choi and James A. Bull

Chemistry A European J, 2016, 22, 16271
DOI: 10.1002/chem.201604031

Oxetane ethers are formed reversibly in the lithium-catalyzed Friedel–Crafts alkylation of phenols with oxetanols: Synthesis of dihydrobenzofurans, diaryloxetanes, and oxetane ethers

Rosemary A. Croft, James J. Mousseau, Chulho Choi and James A. Bull

Tetrahedron, 2018, 74, 5427
DOI: 10.1016/j.tet.2018.02.069

Carbene X H bond insertions catalyzed by copper(I) macrocyclic pyridine-containing ligand (PcL) complexes

Giorgio Tseberlidis, Alessandro Caselli and Rubén Vicente

Journal of Organometallic Chemistry, 2017, 835, 1
DOI: 10.1016/j.jorganchem.2017.02.027

Regioselective and Stereoselective Heck–Matsuda Arylations of Trisubstituted Allylic Alkenols and Their Silyl and Methyl Ether Derivatives To Access Two Contiguous Stereogenic Centers: Expanding the Redox-Relay Process and Application in the Total Synthesis of meso-Hexestrol

Carlise Frota, Ellen Christine Polo, Henrique Esteves and Carlos Roque Duarte Correia

J. Org. Chem., 2018, 83, 2198
DOI: 10.1021/acs.joc.7b03098

Regio- and Stereoselective Synthesis of Sulfur-Bearing Four-Membered Heterocycles: Direct Access to 2,4-Disubstituted Thietane 1-Oxides

Leonardo Degennaro, Laura Carroccia, Giovanna Parisi, Marina Zenzola, Giuseppe Romanazzi, Flavio Fanelli, Luisa Pisano and Renzo Luisi

J. Org. Chem., 2015, 80, 12201
DOI: 10.1021/acs.joc.5b02126

Synthesis of Substituted 1,4-Dioxenes through O–H Insertion and Cyclization Using Keto-Diazo Compounds

Owen A. Davis, Rosemary A. Croft and James A. Bull

J. Org. Chem., 2016, 81, 11477
DOI: 10.1021/acs.joc.6b02134

Controlling the Conformational Energy of a Phenyl Group by Tuning the Strength of a Nonclassical CH···O Hydrogen Bond: The Case of 5-Phenyl-1,3-dioxane

William F. Bailey, Kyle M. Lambert, Zachary D. Stempel, Kenneth B. Wiberg and Brandon Q. Mercado

J. Org. Chem., 2016, 81, 12116
DOI: 10.1021/acs.joc.6b02428

A unified “top-down” approach for the synthesis of diverse lead-like molecular scaffolds

Chloe Townley, Lindsay McMurray, Stephen P. Marsden and Adam Nelson

Bioorganic & Medicinal Chemistry Letters, 2022, 62, 128631
DOI: 10.1016/j.bmcl.2022.128631

Lithium‐Catalyzed Thiol Alkylation with Tertiary and Secondary Alcohols: Synthesis of 3‐Sulfanyl‐Oxetanes as Bioisosteres

Rosemary A. Croft, James J. Mousseau, Chulho Choi and James A. Bull

Chemistry A European J, 2018, 24, 818
DOI: 10.1002/chem.201705576

Synthesis of Structurally Diverse N‐Substituted Quaternary‐Carbon‐Containing Small Molecules from α,α‐Disubstituted Propargyl Amino Esters

Natalia Mateu, Sarah L. Kidd, Leen Kalash, Hannah F. Sore, Andrew Madin, Andreas Bender and David R. Spring

Chemistry A European J, 2018, 24, 13681
DOI: 10.1002/chem.201803143

Construction of a Shape‐Diverse Fragment Set: Design, Synthesis and Screen against Aurora‐A Kinase

Rong Zhang, Patrick J. McIntyre, Patrick M. Collins, Daniel J. Foley, Christopher Arter, Frank von Delft, Richard Bayliss, Stuart Warriner and Adam Nelson

Chemistry A European J, 2019, 25, 6831
DOI: 10.1002/chem.201900815

Harnessing Oxetane and Azetidine Sulfonyl Fluorides for Opportunities in Drug Discovery

Oliver L. Symes, Hikaru Ishikura, Callum S. Begg, Juan J. Rojas, Harry A. Speller, Anson M. Cherk, Marco Fang, Domingo Leung, Rosemary A. Croft, Joe I. Higham, Kaiyun Huang, Anna Barnard, Peter Haycock, Andrew J. P. White, Chulho Choi and James A. Bull

J. Am. Chem. Soc., 2024, 146, 35377
DOI: 10.1021/jacs.4c14164

An efficient morpholinium ionic liquid based catalyst system for cycloaddition of CO2 and epoxides under mild conditions

Yuhan Shang, Qing Gong, Mai Zheng, Haibo Zhang and Xiaohai Zhou

Journal of Molecular Liquids, 2019, 283, 235
DOI: 10.1016/j.molliq.2019.03.089

Synthesis of 3-Aryl-3-Sulfanyl Azetidines by Iron-Catalyzed Thiol Alkylation with N-Cbz Azetidinols

Maryne A. J. Dubois, Anna Lazaridou, Chulho Choi, James J. Mousseau and James A. Bull

J. Org. Chem., 2019, 84, 5943
DOI: 10.1021/acs.joc.9b00613

A One-Pot Reaction of α-Imino Rhodium Carbenoids and Halohydrins: Access to 2,6-Substituted Dihydro-2H-1,4-oxazines

Kieran D. Jones, Michael J. Nutt, Elena Comninos, Alexandre N. Sobolev, Stephen A. Moggach, Tomoya Miura, Masahiro Murakami and Scott G. Stewart

Org. Lett., 2020, 22, 3490
DOI: 10.1021/acs.orglett.0c00947

Thermal Stability and Explosive Hazard Assessment of Diazo Compounds and Diazo Transfer Reagents

Sebastian P. Green, Katherine M. Wheelhouse, Andrew D. Payne, Jason P. Hallett, Philip W. Miller and James A. Bull

Org. Process Res. Dev., 2020, 24, 67
DOI: 10.1021/acs.oprd.9b00422

Rapid Assembly of Saturated Nitrogen Heterocycles in One‐Pot: Diazo‐Heterocycle “Stitching” by N–H Insertion and Cyclization

Alexander J. Boddy, Dominic P. Affron, Christopher J. Cordier, Emma L. Rivers, Alan C. Spivey and James A. Bull

Angew Chem Int Ed, 2019, 58, 1458
DOI: 10.1002/anie.201812925

Divergent Synthesis of Cyclopropane‐Containing Lead‐Like Compounds, Fragments and Building Blocks through a Cobalt Catalyzed Cyclopropanation of Phenyl Vinyl Sulfide

Stephen J. Chawner, Manuel J. Cases‐Thomas and James A. Bull

Eur J Org Chem, 2017, 2017, 5015
DOI: 10.1002/ejoc.201701030

Evaluierung neuer Reaktionen zur Steuerung der Wirkstoff‐Forschung: ein Eignungstest

Daniel J. Foley, Adam Nelson and Stephen P. Marsden

Angewandte Chemie, 2016, 128, 13850
DOI: 10.1002/ange.201604193

Catalyst- and Substituent-Controlled Regio- and Stereoselective Synthesis of Indolyl Acrylates by Lewis-Acid-Catalyzed Direct Functionalization of 3-Formylindoles with Diazo Esters

Sana Jamshaid, Shreedhar Devkota and Yong Rok Lee

Org. Lett., 2021, 23, 2140
DOI: 10.1021/acs.orglett.1c00277

Continuous Process to Safely Manufacture an Aryldiazoacetate and Its Direct Use in a Dirhodium-Catalyzed Enantioselective Cyclopropanation

Stephen P. Lathrop, Laurie B. Mlinar, Onkar N. Manjrekar, Yong Zhou, Kaid C. Harper, Eric R. Sacia, Molly Higgins, Andrew R. Bogdan, Zhe Wang, Steven M. Richter, Wei Gong, Eric A. Voight, Jeremy Henle, Moiz Diwan, Jeffrey M. Kallemeyn, Jack C. Sharland, Bo Wei and Huw M. L. Davies

Org. Process Res. Dev., 2023, 27, 90
DOI: 10.1021/acs.oprd.2c00288

Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections

Sarah L. Kidd, Thomas J. Osberger, Natalia Mateu, Hannah F. Sore and David R. Spring

Front. Chem., 2018, 6
DOI: 10.3389/fchem.2018.00460

Chemical Space Exploration of Oxetanes

Fernando Rodrigues de Sá Alves, Rafael M. Couñago and Stefan Laufer

IJMS, 2020, 21, 8199
DOI: 10.3390/ijms21218199

Unified synthesis of diverse building blocks for application in the discovery of bioactive small molecules

Scott Rice, Daniel J. Cox, Stephen P. Marsden and Adam Nelson

Tetrahedron, 2019, 75, 130513
DOI: 10.1016/j.tet.2019.130513

Catalytic Regioselective Isomerization of 2,2‐Disubstituted Oxetanes to Homoallylic Alcohols

Albert Cabré, Sergi Rafael, Giuseppe Sciortino, Gregori Ujaque, Xavier Verdaguer, Agustí Lledós and Antoni Riera

Angewandte Chemie, 2020, 132, 7591
DOI: 10.1002/ange.201915772

ChemInform Abstract: Synthesis of Diversely Functionalized 2,2‐Disubstituted Oxetanes: Fragment Motifs in New Chemical Space.

Owen A. Davis, Rosemary A. Croft and James A. Bull

ChemInform, 2016, 47
DOI: 10.1002/chin.201608116

Synthesis of oxetane/azetidine containing spirocycles via the 1,3-dipolar cycloaddition reaction

Benjamin Jones, Mitchell Proud and Visuvanathar Sridharan

Tetrahedron Letters, 2016, 57, 2811
DOI: 10.1016/j.tetlet.2016.05.053

Homologation of Alkyl Acetates, Alkyl Ethers, Acetals, and Ketals by Formal Insertion of Diazo Compounds into a Carbon–Carbon Bond

Fei Wang, Junyi Yi, Yoshihiro Nishimoto and Makoto Yasuda

Synthesis, 2021, 53, 4004
DOI: 10.1055/a-1523-1551

Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry

James A. Bull, Rosemary A. Croft, Owen A. Davis, Robert Doran and Kate F. Morgan

Chem. Rev., 2016, 116, 12150
DOI: 10.1021/acs.chemrev.6b00274

Rapid Assembly of Saturated Nitrogen Heterocycles in One‐Pot: Diazo‐Heterocycle “Stitching” by N–H Insertion and Cyclization

Alexander J. Boddy, Dominic P. Affron, Christopher J. Cordier, Emma L. Rivers, Alan C. Spivey and James A. Bull

Angewandte Chemie, 2019, 131, 1472
DOI: 10.1002/ange.201812925

Diazo chemistry in the access to novel fatty acids linked to spiro-fused oxetane-pyrazolone scaffold

Igor Solovyev, Dmitry Dar'in and Mikhail Krasavin

Mendeleev Communications, 2023, 33, 21
DOI: 10.1016/j.mencom.2023.01.006

Oxygen- and Sulphur-Containing Heterocyclic Compounds as Potential Anticancer Agents

Harshita Sachdeva, Sarita Khaturia, Mohammad Saquib, Narsingh Khatik, Abhinav Raj Khandelwal, Ravina Meena and Khushboo Sharma

Appl Biochem Biotechnol, 2022, 194, 6438
DOI: 10.1007/s12010-022-04099-w

The Symbiotic Relationship Between Drug Discovery and Organic Chemistry

Oleksandr O. Grygorenko, Dmitriy M. Volochnyuk, Sergey V. Ryabukhin and Duncan B. Judd

Chemistry A European J, 2020, 26, 1196
DOI: 10.1002/chem.201903232

Thermolysis of 2-diazo-3-aryl ketoesters: New route to α-aryl malonates and aromatic esters

Zhao Zhang, Mengyao Tang, Lei Zang, Liang-Hua Zou and Jie Li

Tetrahedron Letters, 2016, 57, 5681
DOI: 10.1016/j.tetlet.2016.11.016

Flow microreactor synthesis of 2,2-disubstituted oxetanes via 2-phenyloxetan-2-yl lithium

Leonardo Degennaro, Aiichiro Nagaki, Yuya Moriwaki, Giuseppe Romanazzi, Maria Michela DelľAnna, Jun-ichi Yoshida and Renzo Luisi

Open Chemistry, 2016, 14, 377
DOI: 10.1515/chem-2016-0041

Catalytic Regioselective Isomerization of 2,2‐Disubstituted Oxetanes to Homoallylic Alcohols

Albert Cabré, Sergi Rafael, Giuseppe Sciortino, Gregori Ujaque, Xavier Verdaguer, Agustí Lledós and Antoni Riera

Angew Chem Int Ed, 2020, 59, 7521
DOI: 10.1002/anie.201915772