Efforts toward elucidating Thalidomide’s molecular target: an expedient synthesis of the first Thalidomide biotin analogue

Scott G. Stewart, Carlos J. Braun, Marta E. Polomska, Mahdad Karimi, Lawrence J. Abraham and Keith A. Stubbs

Org. Biomol. Chem., 2010, 8, 4059
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Concise synthesis of catechin probes enabling analysis and imaging of EGCg

Atsushi Yoshida, Yasuo Hirooka, Yusuke Sugata, Mariko Nitta, Tamiko Manabe, Shunsuke Ido, Kouki Murakami, Repon Kumer Saha, Takashi Suzuki, Motohiro Ohshima, Akira Yoshida, Kunihiko Itoh, Kosuke Shimizu, Naoto Oku, Takumi Furuta, Tomohiro Asakawa, Toshiyuki Wakimoto and Toshiyuki Kan

Chem. Commun., 2011, 47, 1794
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Selective Reconstitution and Recovery of Functional γ-Secretase Complex on Budded Baculovirus Particles

Ikuo Hayashi, Yasuomi Urano, Rie Fukuda, Noriko Isoo, Tatsuhiko Kodama, Takao Hamakubo, Taisuke Tomita and Takeshi Iwatsubo

Journal of Biological Chemistry, 2004, 279, 38040
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Biological significance and development of practical synthesis of biotin

Masahiko Seki

Medicinal Research Reviews, 2006, 26, 434
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Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands

Xue Zhi Zhao, Elena A. Semenova, Chenzhong Liao, Marc Nicklaus, Yves Pommier and Terrence R. Burke

Bioorganic & Medicinal Chemistry, 2006, 14, 7816
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FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons

Nobumasa Takasugi, Tomoki Sasaki, Ihori Ebinuma, Satoko Osawa, Hayato Isshiki, Koji Takeo, Taisuke Tomita, Takeshi Iwatsubo and Koichi M. Iijima

PLoS ONE, 2013, 8, e64050
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Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer’s Disease

Collin Y. Liu, Yu Ohki, Taisuke Tomita, Satoko Osawa, Bruce R. Reed, William Jagust, Victoria Van Berlo, Lee-Way Jin, Helena C. Chui, Giovanni Coppola and John M. Ringman

Journal of Alzheimer’s Disease, 2017, 58, 1035
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Concise and Short Synthesis of Functionalized 5,6-Dihydropyridin-2-ones by Means of Palladium(0)-Catalyzed Cross-Coupling of Ketene Aminal Phosphates

Makoto Sasaki, Haruhiko Fuwa, Akane Kaneko, Yasuaki Sugimoto, Taisuke Tomita and Takeshi Iwatsubo

HETEROCYCLES, 2006, 70, 101
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Synthesis of Chemical-Biology Tools Enabling in vivo Imaging and Analysis of Epigallocatechin Gallate

Tomohiro Asakawa, Atsushi Yoshida, Yasuo Hirooka, Takashi Suzuki, Kunihiko Itoh, Kosuke Shimizu, Naoto Oku, Takumi Furuta, Toshiyuki Wakimoto, Makoto Inai and Toshiyuki Kan

HETEROCYCLES, 2016, 93, 218
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Convenient Synthesis of Photoaffinity Probes and Evaluation of Their Labeling Abilities

Toshiyuki Kan, Yoichi Kita, Yuichi Morohashi, Yusuke Tominari, Shinnosuke Hosoda, Taisuke Tomita, Hideaki Natsugari, Takeshi Iwatsubo and Tohru Fukuyama

Org. Lett., 2007, 9, 2055
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Inhibition of γ-Secretase Activity by a Monoclonal Antibody against the Extracellular Hydrophilic Loop of Presenilin 1

Shizuka Takagi-Niidome, Satoko Osawa, Taisuke Tomita and Takeshi Iwatsubo

Biochemistry, 2013, 52, 61
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C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-Butyl Ester)

Yuichi Morohashi, Toshiyuki Kan, Yusuke Tominari, Haruhiko Fuwa, Yumiko Okamura, Naoto Watanabe, Chihiro Sato, Hideaki Natsugari, Tohru Fukuyama, Takeshi Iwatsubo and Taisuke Tomita

Journal of Biological Chemistry, 2006, 281, 14670
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The 4-nitrobenzenesulfonyl group as a convenient N-protecting group for iminosugars—synthesis of oligosaccharide inhibitors of heparanase

Zsuzsánna Csíki and Péter Fügedi

Tetrahedron Letters, 2010, 51, 391
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Total Syntheses of (+)-Sesamin and (+)-Sesaminol

Ryo Ishikawa, Naoto Yoshida, Yusuke Akao, Yusuke Kawabe, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima and Toshiyuki Kan

Chemistry Letters, 2014, 43, 1572
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Labeling study of avidin by modular method for affinity labeling (MoAL)

Shuichi Nakanishi, Hiroyuki Tanaka, Kazuhito Hioki, Kohei Yamada and Munetaka Kunishima

Bioorganic & Medicinal Chemistry Letters, 2010, 20, 7050
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Divergent Synthesis of Multifunctional Molecular Probes To Elucidate the Enzyme Specificity of Dipeptidic γ-Secretase Inhibitors

Haruhiko Fuwa, Yasuko Takahashi, Yu Konno, Naoto Watanabe, Hiroyuki Miyashita, Makoto Sasaki, Hideaki Natsugari, Toshiyuki Kan, Tohru Fukuyama, Taisuke Tomita and Takeshi Iwatsubo

ACS Chem. Biol., 2007, 2, 408
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Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger–aza-Wittig reaction of ω-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues

Haruhiko Fuwa, Yumiko Okamura, Yuichi Morohashi, Taisuke Tomita, Takeshi Iwatsubo, Toshiyuki Kan, Tohru Fukuyama and Hideaki Natsugari

Tetrahedron Letters, 2004, 45, 2323
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Synthesis of Food Effective Constituents toward the Development for Chemical Biology Investigations

Makoto Inai, Tomohiro Asakawa and Toshiyuki Kan

J. Syn. Org. Chem., Jpn., 2016, 74, 412
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Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

Haruhiko Fuwa, Kenichi Hiromoto, Yasuko Takahashi, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama, Takeshi Iwatsubo, Taisuke Tomita and Hideaki Natsugari

Bioorganic & Medicinal Chemistry Letters, 2006, 16, 4184
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Practical Synthesis of Kainoids: A New Chemical Probe Precursor and a Fluorescent Probe

Shingo Sasaki, Hiroto Suzuki, Hitoshi Ouchi, Tomohiro Asakawa, Makoto Inai, Ryuichi Sakai, Keiko Shimamoto, Yoshitaka Hamashima and Toshiyuki Kan

Org. Lett., 2014, 16, 564
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Concise synthesis of dideoxy-epigallocatechin gallate (DO-EGCG) and evaluation of its anti-influenza virus activity

Takumi Furuta, Yasuo Hirooka, Ayako Abe, Yusuke Sugata, Mitsuru Ueda, Kouki Murakami, Takashi Suzuki, Kiyoshi Tanaka and Toshiyuki Kan

Bioorganic & Medicinal Chemistry Letters, 2007, 17, 3095
DOI: 10.1016/j.bmcl.2007.03.041

Parallel synthesis of DAPT derivatives and their γ-secretase-inhibitory activity

Toshiyuki Kan, Yusuke Tominari, Kentaro Rikimaru, Yuichi Morohashi, Hideaki Natsugari, Taisuke Tomita, Takeshi Iwatsubo and Tohru Fukuyama

Bioorganic & Medicinal Chemistry Letters, 2004, 14, 1983
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BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate

Nobumasa Takasugi, Tomoki Sasaki, Kunimichi Suzuki, Satoko Osawa, Hayato Isshiki, Yukiko Hori, Naoaki Shimada, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Virginia M.-Y. Lee, John Q. Trojanowski, Taisuke Tomita and Takeshi Iwatsubo

J. Neurosci., 2011, 31, 6850
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Structure of the Catalytic Pore of γ-Secretase Probed by the Accessibility of Substituted Cysteines

Chihiro Sato, Yuichi Morohashi, Taisuke Tomita and Takeshi Iwatsubo

J. Neurosci., 2006, 26, 12081
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Combinatorial Chemistry Online

N.K Terrett

Combinatorial Chemistry - an Online Journal, 2003, 5, 35
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Inhibition of γ-Secretase Activity by Helical β-Peptide Foldamers

Yuki Imamura, Naoto Watanabe, Naoki Umezawa, Takeshi Iwatsubo, Nobuki Kato, Taisuke Tomita and Tsunehiko Higuchi

J. Am. Chem. Soc., 2009, 131, 7353
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Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates

Yasuko Takahashi, Haruhiko Fuwa, Akane Kaneko, Makoto Sasaki, Satoshi Yokoshima, Hifumi Koizumi, Tohru Takebe, Toshiyuki Kan, Takeshi Iwatsubo, Taisuke Tomita, Hideaki Natsugari and Tohru Fukuyama

Bioorganic & Medicinal Chemistry Letters, 2006, 16, 3813
DOI: 10.1016/j.bmcl.2006.04.025

Tubulin Photoaffinity Labeling with Biotin‐Tagged Derivatives of Potent Diketopiperazine Antimicrotubule Agents

Yuri Yamazaki , Kyoko Kohno, Hiroyuki Yasui, Yoshiaki Kiso, Miki Akamatsu, Benjamin Nicholson, Gordafaried Deyanat‐Yazdi, Saskia Neuteboom, Barbara Potts, G. Kenneth Lloyd and Yoshio Hayashi

ChemBioChem, 2008, 9, 3074
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Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker

Satoshi Yokoshima, Yuzo Abe, Naoto Watanabe, Yoichi Kita, Toshiyuki Kan, Takeshi Iwatsubo, Taisuke Tomita and Tohru Fukuyama

Bioorganic & Medicinal Chemistry Letters, 2009, 19, 6869
DOI: 10.1016/j.bmcl.2009.10.086