Issue 11, 2024

H2O2-triggered controllable carbon monoxide delivery for photothermally augmented gas therapy

Abstract

Carbon monoxide (CO) gas therapy has shown great potential as a very promising approach in the ongoing fight against tumors. However, delivering unstable CO to the tumor site and safely releasing it for maximum efficacy still have unsatisfactory outcomes. In this study, we've developed nanotheranostics (IN-DPPCO NPs) based on conjugated polymer IN-DPP and carbon monoxide (CO) carrier polymer mPEG(CO) for photothermal augmented gas therapy. The IN-DPPCO NPs can release CO with the hydrogen peroxide (H2O2) overexpressed in the tumor microenvironment. Meanwhile, IN-DPPCO NPs exhibit strong absorption in the near-infrared window, showing a high photothermal conversion efficiency of up to 41.5% under 808 nm laser irradiation. In vitro and in vivo experiments demonstrate that these nanotheranostics exhibit good biocompatibility. Furthermore, the synergistic CO/photothermal therapy shows enhanced therapeutic efficacy compared to gas therapy alone. This work highlights the great promise of conjugated polymer nanoparticles as versatile nanocarriers for spatiotemporally controlled and on-demand delivery of gaseous messengers to achieve precision cancer theranostics.

Graphical abstract: H2O2-triggered controllable carbon monoxide delivery for photothermally augmented gas therapy

Supplementary files

Article information

Article type
Paper
Submitted
13 okt 2023
Accepted
08 feb 2024
First published
09 feb 2024

J. Mater. Chem. B, 2024,12, 2737-2745

H2O2-triggered controllable carbon monoxide delivery for photothermally augmented gas therapy

K. Chang, X. Sun, M. Fu, B. Han, X. Jiang, Q. Qi, Y. Zhang, T. Ni, C. Ge and Z. Yang, J. Mater. Chem. B, 2024, 12, 2737 DOI: 10.1039/D3TB02399K

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