Issue 9, 2023

Gold-catalyzed multicomponent reactions

Abstract

Multicomponent reactions (MCRs) have emerged as an important branch in organic synthesis for the creation of complex molecular structures from more than two starting materials in a one-pot fashion. Conventionally, the use of transition metals as catalysts has been well-known for achieving MCRs and a number of reviews on this topic are documented in the literature. Gold, unlike other transition metals, offers unique reactivity profiles meaning that newer molecules which were previously inaccessible can be synthesized. In the past few years, gold catalysts have emerged as powerful contenders for achieving MCRs that are unique on mechanistic grounds. This comprehensive review summarizes the state-of-the-art in the development of gold-catalyzed MCRs with a special emphasis on recent developments.

Graphical abstract: Gold-catalyzed multicomponent reactions

Article information

Article type
Review Article
Submitted
23 feb 2023
Accepted
21 mar 2023
First published
22 mar 2023

Org. Chem. Front., 2023,10, 2359-2384

Gold-catalyzed multicomponent reactions

A. G. Tathe, S. S. Saswade and N. T. Patil, Org. Chem. Front., 2023, 10, 2359 DOI: 10.1039/D3QO00272A

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