Issue 23, 2023

Microencapsulation of alcohol solvents and high-content actives for efficient transdermal delivery

Abstract

The barrier function of the skin in effectively protecting the underlying tissue from the surrounding environment makes it challenging to achieve the efficient transdermal delivery of actives. Herein, we report on alcohol-solvent-encapsulated microcapsules to achieve enhanced skin efficacy. We show that using palm oil as the shell material allows for the microencapsulation of a broad range of alcohol solvents, including ethanol and dipropylene glycol (DPG), as well as on-demand release. Moreover, clinical trials reveal that the high-content actives in microcapsules result in enhanced skin efficacy, and the presence of DPG effectively mediates the transdermal delivery of these actives without causing any skin irritation. We envision that the alcohol-solvent microencapsulation strategy outlined in this work offers new possibilities in cosmetics, food, and drug delivery systems.

Graphical abstract: Microencapsulation of alcohol solvents and high-content actives for efficient transdermal delivery

Supplementary files

Article information

Article type
Paper
Submitted
30 aug 2023
Accepted
28 sep 2023
First published
28 sep 2023

Biomater. Sci., 2023,11, 7531-7540

Microencapsulation of alcohol solvents and high-content actives for efficient transdermal delivery

J. H. Lee, Y. Hwang, M. Noh, J. H. Lee, J. B. Lee and H. Lee, Biomater. Sci., 2023, 11, 7531 DOI: 10.1039/D3BM01411H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements