Issue 23, 2023

A mitochondrion-targeted fluorescent probe based on ESIPT phthalimide for the detection of Hg2+ with large Stokes shift

Abstract

A novel mitochondrion-targeted Hg2+-specific fluorescent probe 1 based on ESIPT phthalimide was designed and synthesized for the first time. Owing to the blockage of the ESIPT process between the hydroxy group and the carbonyl oxygen of the imide by the diphenylphosphinothioate group, 1 was almost nonfluorescent. After reacting with Hg2+, 1 exhibited a dramatic fluorescence enhancement due to the recovery of the ESIPT process through Hg2+-induced desulfurization-hydrolysis of the diphenylphosphinothioate moiety and the cleavage of the P–O bond. 1 showed a large Stokes shift, rapid response and high sensitivity and selectivity for Hg2+ over other metal ions. Moreover, 1 was successfully employed to image Hg2+ in the mitochondria of living cells.

Graphical abstract: A mitochondrion-targeted fluorescent probe based on ESIPT phthalimide for the detection of Hg2+ with large Stokes shift

Supplementary files

Article information

Article type
Paper
Submitted
30 sep 2023
Accepted
22 okt 2023
First published
02 nov 2023

Analyst, 2023,148, 5882-5888

A mitochondrion-targeted fluorescent probe based on ESIPT phthalimide for the detection of Hg2+ with large Stokes shift

A. Ren, W. Yao and D. Zhu, Analyst, 2023, 148, 5882 DOI: 10.1039/D3AN01671D

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