Issue 31, 2021

Impact of molecular rigidity on the gene delivery efficiency of core–shell tecto dendrimers

Abstract

We report the construction of two types of core–shell tecto dendrimers (CSTDs) with different core rigidities to illustrate the impact of molecular rigidity on their gene delivery efficiency. Our study reveals that CSTDs designed with rigid cores enable promoted gene delivery, providing many possibilities for a wide range of gene delivery-associated biomedical applications.

Graphical abstract: Impact of molecular rigidity on the gene delivery efficiency of core–shell tecto dendrimers

Supplementary files

Article information

Article type
Communication
Submitted
14 jun 2021
Accepted
16 jul 2021
First published
19 jul 2021

J. Mater. Chem. B, 2021,9, 6149-6154

Impact of molecular rigidity on the gene delivery efficiency of core–shell tecto dendrimers

D. Wang, L. Chen, Y. Gao, C. Song, Z. Ouyang, C. Li, S. Mignani, J. Majoral, X. Shi and M. Shen, J. Mater. Chem. B, 2021, 9, 6149 DOI: 10.1039/D1TB01328A

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