Issue 97, 2021

Recent advances in the synthesis of N-heteroarenes via catalytic dehydrogenation of N-heterocycles

Abstract

Bio-active molecules having N-heteroarene core are widely used for numerous medicinal applications and as lifesaving drugs. In this direction, dehydrogenation of partially saturated aromatic N-heterocycles shows utmost importance for the synthesis of heterocycles. This feature article highlights the recent advances, from 2009 to April 2021, on the dehydrogenation of N-heteroaromatics. Notable features considering the development of newer catalysis for dehydrogenations are: (i) approaches based on precious metal catalysis, (ii) newer strategies and catalyst development technology using non-precious metal-catalysts for N-heterocycles having one or more heteroatoms, (iii) Synthesis of five or six-membered N-heterocycles using photocatalysis, electrocatalytic, and organo-catalytic approaches using different homogeneous and heterogeneous conditions’ (iv) metal free (base and acid-promoted) dehydrogenation along with I2, N-hydroxyphthalimide (NHPI) and bio catalyzed miscellaneous examples have also been discussed, (v) mechanistic studies for various dehydrogenation reactions and (vi) synthetic applications of various bio-active molecules including post-drug derivatization are discussed.

Graphical abstract: Recent advances in the synthesis of N-heteroarenes via catalytic dehydrogenation of N-heterocycles

Article information

Article type
Feature Article
Submitted
01 sep 2021
Accepted
27 okt 2021
First published
27 okt 2021

Chem. Commun., 2021,57, 13042-13058

Recent advances in the synthesis of N-heteroarenes via catalytic dehydrogenation of N-heterocycles

A. Bera, S. Bera and D. Banerjee, Chem. Commun., 2021, 57, 13042 DOI: 10.1039/D1CC04919D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements