Issue 95, 2019

Cooperative enhancement of antibacterial activity of sanguinarine drug through p-sulfonatocalix[6]arene functionalized silver nanoparticles

Abstract

The amelioration of antibacterial efficacy along with the reduced minimum inhibitory concentration (MIC) of sanguinarine (SGR) drug have been demonstrated through the uptake of SGR by p-sulfonatocalix[6]arene functionalized silver nanoparticles. The large upward pKa shift and enhanced stability of SGR resulting from the favorable supra-nanomolecular strategy are deciphered into an improved antibacterial drug against different pathogenic micro-organisms including multi drug resistant bacteria.

Graphical abstract: Cooperative enhancement of antibacterial activity of sanguinarine drug through p-sulfonatocalix[6]arene functionalized silver nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
19 sep 2019
Accepted
04 nov 2019
First published
05 nov 2019

Chem. Commun., 2019,55, 14275-14278

Cooperative enhancement of antibacterial activity of sanguinarine drug through p-sulfonatocalix[6]arene functionalized silver nanoparticles

C. Mehra, R. Gala, A. Kakatkar, V. Kumar, R. Khurana, S. Chatterjee, N. N. Kumar, N. Barooah, A. C. Bhasikuttan and J. Mohanty, Chem. Commun., 2019, 55, 14275 DOI: 10.1039/C9CC07378G

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