Issue 16, 2018

Asperones A–E, five dimeric polyketides with new carbon skeletons from the fungus Aspergillus sp. AWG 1–15

Abstract

Asperones A–E (1–5), five dimeric polyketides with two distinct skeletons generated by the crucial [3 + 2] and [3 + 3] cycloadditions, were isolated from fungal metabolites of an Aspergillus sp. Their structures were established by spectroscopic data, chemical derivatization, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Compounds 2–4 showed significant nitric oxide (NO) inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophage cells, and exhibited IC50 values of 16.0, 13.2, and 6.0 μM, respectively.

Graphical abstract: Asperones A–E, five dimeric polyketides with new carbon skeletons from the fungus Aspergillus sp. AWG 1–15

Supplementary files

Article information

Article type
Research Article
Submitted
21 jan 2018
Accepted
14 mar 2018
First published
15 mar 2018

Org. Chem. Front., 2018,5, 2432-2436

Asperones A–E, five dimeric polyketides with new carbon skeletons from the fungus Aspergillus sp. AWG 1–15

G. Yin, Y. Wu, C. Han, X. Wang, H. Gao, Y. Yin, L. Kong and M. Yang, Org. Chem. Front., 2018, 5, 2432 DOI: 10.1039/C8QO00070K

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