Issue 4, 2018

Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes

Abstract

We report a novel metal–organic framework (MOF) featuring functional pores decorated with hydroxyl groups derived from the natural amino acid L-serine, which is able to establish specific interactions of different natures, strengths and directionalities with organic molecules of technological interest, i.e. ascorbic acid, pyridoxine, bupropion and 17-β-estradiol, based on their different sizes and chemical natures. The ability of 1 to distinctly organize guest molecules within its channels, through the concomitant effect of different directing supramolecular host–guest interactions, enables gaining unique insights, by means of single-crystal X-ray crystallography, into the host–guest interactions. These results increase our understanding of molecular recognition processes in MOFs, opening a myriad of potential technological applications in the near future.

Graphical abstract: Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes

Supplementary files

Article information

Article type
Communication
Submitted
13 mar 2018
Accepted
19 apr 2018
First published
19 apr 2018

Mater. Horiz., 2018,5, 683-690

Crystallographic snapshots of host–guest interactions in drugs@metal–organic frameworks: towards mimicking molecular recognition processes

M. Mon, R. Bruno, J. Ferrando-Soria, L. Bartella, L. Di Donna, M. Talia, R. Lappano, M. Maggiolini, D. Armentano and E. Pardo, Mater. Horiz., 2018, 5, 683 DOI: 10.1039/C8MH00302E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements