Issue 10, 2018

Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies

Abstract

The delivery of proteins into cells is a potential game changer for a wide array of therapeutic purposes, including cancer therapy, immunomodulation and treatment of inherited diseases. In this review, we present recently developed nanoassemblies for protein delivery that utilize strategies that range from direct assembly, encapsulation and composite formation. We will discuss factors that affect the efficacy of nanoassemblies for delivery from the perspective of both nanoparticles and proteins. Challenges in the field, particularly achieving effective cytosolar protein delivery through endosomal escape or evasion are discussed.

Graphical abstract: Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies

Article information

Article type
Tutorial Review
Submitted
03 jan 2018
First published
14 mar 2018

Chem. Soc. Rev., 2018,47, 3421-3432

Author version available

Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies

F. Scaletti, J. Hardie, Y. Lee, D. C. Luther, M. Ray and V. M. Rotello, Chem. Soc. Rev., 2018, 47, 3421 DOI: 10.1039/C8CS00008E

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