Issue 80, 2013

Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

Abstract

We describe coumarin derivatives that are non-fluorescent in aqueous buffers and that very selectively bind to transthyretin (TTR) in complex biological environments potently inhibiting TTR amyloidogenesis while also exhibiting sensitive off–on fluorescent sensing of the properly folded quaternary structure of TTR.

Graphical abstract: Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

Supplementary files

Article information

Article type
Communication
Submitted
21 jun 2013
Accepted
06 aug 2013
First published
07 aug 2013

Chem. Commun., 2013,49, 9188-9190

Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors

N. Myung, S. Connelly, B. Kim, S. J. Park, I. A. Wilson, J. W. Kelly and S. Choi, Chem. Commun., 2013, 49, 9188 DOI: 10.1039/C3CC44667K

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