Issue 8, 2024

A ZIF-8-encapsulated interpenetrated hydrogel/nanofiber composite patch for chronic wound treatment

Abstract

Designing wound dressings necessitates the crucial considerations of maintaining a moist environment and implementing effective bacterial control. Furthermore, developing a three-dimensional framework emulating the extracellular matrix (ECM) confers advantages in fostering cellular migration and proliferation. Inspired by this, hydrogel/nanofiber composites have been demonstrated as promising materials for wound dressings. The composites also overcome the disadvantages of poor mechanical properties and rapid release of traditional pure hydrogels. In this study, we constructed a calcium alginate hydrogel/polylactic acid nanofiber (CAH/PLANF) composite with an interpenetrated network. Additionally, the synthesis of zeolitic imidazolate framework-8 (ZIF-8) incorporated into the composite system endowed the system with enhanced mechanical properties and photodynamic antibacterial attributes. The obtained composite patch (ZIF-8@CAH/PLANF) exhibited excellent swelling, strong mechanical properties, low cytotoxicity, and durable photodynamic antibacterial effect with an antibacterial efficacy of higher than 99.99%. Finally, bacterial infection and wound healing properties were investigated in vivo, and the ZIF-8@CAH/PLANF patch was proven to have the ability to fight infection and accelerate wound healing.

Graphical abstract: A ZIF-8-encapsulated interpenetrated hydrogel/nanofiber composite patch for chronic wound treatment

Supplementary files

Article information

Article type
Paper
Submitted
12 nov 2023
Accepted
23 jan 2024
First published
26 jan 2024

J. Mater. Chem. B, 2024,12, 2042-2053

A ZIF-8-encapsulated interpenetrated hydrogel/nanofiber composite patch for chronic wound treatment

H. Cheng, M. A. A. Newton, M. Rajib, Q. Zhang, W. Gao, Z. Lu, Y. Zheng, Z. Dai and J. Zhu, J. Mater. Chem. B, 2024, 12, 2042 DOI: 10.1039/D3TB02683C

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