Issue 11, 2024

Trends in bioactivity: inducing and detecting mineralization of regenerative polymeric scaffolds

Abstract

Due to limitations of biological and alloplastic grafts, regenerative engineering has emerged as a promising alternative to treat bone defects. Bioactive polymeric scaffolds are an integral part of such an approach. Bioactivity importantly induces hydroxyapatite mineralization that promotes osteoinductivity and osseointegration with surrounding bone tissue. Strategies to confer bioactivity to polymeric scaffolds utilize bioceramic fillers, coatings and surface treatments, and additives. These approaches can also favorably impact mechanical and degradation properties. A variety of fabrication methods are utilized to prepare scaffolds with requisite morphological features. The bioactivity of scaffolds may be evaluated with a broad set of techniques, including in vitro (acellular and cellular) and in vivo methods. Herein, we highlight contemporary and emerging approaches to prepare and assess scaffold bioactivity, as well as existing challenges.

Graphical abstract: Trends in bioactivity: inducing and detecting mineralization of regenerative polymeric scaffolds

Article information

Article type
Perspective
Submitted
10 nov 2023
Accepted
14 feb 2024
First published
16 feb 2024
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2024,12, 2720-2736

Trends in bioactivity: inducing and detecting mineralization of regenerative polymeric scaffolds

B. M. Nitschke, F. O. Beltran, M. S. Hahn and M. A. Grunlan, J. Mater. Chem. B, 2024, 12, 2720 DOI: 10.1039/D3TB02674D

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