Issue 7, 2024

Stimuli-responsive peptide hydrogels for biomedical applications

Abstract

Stimuli-responsive hydrogels can respond to external stimuli with a change in the network structure and thus have potential application in drug release, intelligent sensing, and scaffold construction. Peptides possess robust supramolecular self-assembly ability, enabling spontaneous formation of nanostructures through supramolecular interactions and subsequently hydrogels. Therefore, peptide-based stimuli-responsive hydrogels have been widely explored as smart soft materials for biomedical applications in the last decade. Herein, we present a review article on design strategies and research progress of peptide hydrogels as stimuli-responsive materials in the field of biomedicine. The latest design and development of peptide hydrogels with responsive behaviors to stimuli are first presented. The following part provides a systematic overview of the functions and applications of stimuli-responsive peptide hydrogels in tissue engineering, drug delivery, wound healing, antimicrobial treatment, 3D cell culture, biosensors, etc. Finally, the remaining challenges and future prospects of stimuli-responsive peptide hydrogels are proposed. It is believed that this review will contribute to the rational design and development of stimuli-responsive peptide hydrogels toward biomedical applications.

Graphical abstract: Stimuli-responsive peptide hydrogels for biomedical applications

Article information

Article type
Review Article
Submitted
03 nov 2023
Accepted
18 jan 2024
First published
20 jan 2024

J. Mater. Chem. B, 2024,12, 1748-1774

Stimuli-responsive peptide hydrogels for biomedical applications

H. Zhou, Y. Zhu, B. Yang, Y. Huo, Y. Yin, X. Jiang and W. Ji, J. Mater. Chem. B, 2024, 12, 1748 DOI: 10.1039/D3TB02610H

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