Multiphase photochemistry in flow mode via an integrated continuous stirred tank reactor (CSTR) approach

Antonella Ilenia Alfano; Megan Smyth; Scott Wharry; Thomas S. Moody; Manuel Nuño; Chris Butters; Marcus Baumann

doi:10.1039/D4CC02477J

Multiphase photochemistry in flow mode via an integrated continuous stirred tank reactor (CSTR) approach†

Antonella Ilenia Alfano,

*^a Megan Smyth,

^b Scott Wharry,

^b Thomas S. Moody,

^bc Manuel Nuño,

^d Chris Butters^d and Marcus Baumann

*^a

Author affiliations

* Corresponding authors

^a School of Chemistry, University College Dublin, Science Centre South, Dublin 4, Ireland
E-mail: marcus.baumann@ucd.ie

^b Almac Sciences, Technology Department, Craigavon BT63 5QD, UK

^c Arran Chemical Company, Monksland Industrial Estate, Roscommon N37 DN24, Ireland

^d Vapourtec, Fornham St Genevieve, Bury St Edmunds, Suffolk, UK

Abstract

A new photochemical CSTR system capable of handling solids in scaled continuous processes is presented. High-power UV-LEDs are integrated in these CSTRs containing an insoluble base that aids in generating pyrazolines via cycloaddition between alkenes and in situ generated diazo species. Contrary to reported batch methods product degradation via ring contraction is suppressed whilst generating gram quantities of spirocyclic pyrazolines.

This article is part of the themed collection: CC 60th Anniversary Authors Collection

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DOI: https://doi.org/10.1039/D4CC02477J
Article type: Communication
Submitted: 21 mai 2024
Accepted: 12 jun 2024
First published: 13 jun 2024
This article is Open Access

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Chem. Commun., 2024, Advance Article

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Multiphase photochemistry in flow mode via an integrated continuous stirred tank reactor (CSTR) approach

A. I. Alfano, M. Smyth, S. Wharry, T. S. Moody, M. Nuño, C. Butters and M. Baumann, Chem. Commun., 2024, Advance Article , DOI: 10.1039/D4CC02477J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Communications

Multiphase photochemistry in flow mode via an integrated continuous stirred tank reactor (CSTR) approach†

Abstract

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Multiphase photochemistry in flow mode via an integrated continuous stirred tank reactor (CSTR) approach

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