Issue 18, 2023

Inflammation-targeting polyamine nanomedicines for the treatment of ulcerative colitis

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by immune system dysfunction. Despite the availability of various anti-inflammatory drugs, they exhibit low therapeutic efficacy with systemic side effects. In this study, we developed oral anti-inflammatory polyamine-based nanomedicines for the treatment of ulcerative colitis. Polyamine-bearing nanoparticles were prepared by the self-assembly of hyaluronic acid in organic solvents and crosslinking with branched oligoethyleneimine. Polyamine nanoparticles were found to suppress excessive inflammatory responses by scavenging the reactive oxygen species (ROS). Moreover, these nanoparticles inhibited enzymatic degradation and targeting of inflamed intestinal tissues. Additionally, they suppressed the inflammatory responses and recovered the pathological disorders in the colon of an ulcerative colitis mouse model. Therefore, polyamine-based nanomedicines exhibit great potential as biocompatible ROS-scavenging drugs for the treatment of IBD.

Graphical abstract: Inflammation-targeting polyamine nanomedicines for the treatment of ulcerative colitis

Article information

Article type
Paper
Submitted
27 feb 2023
Accepted
03 apr 2023
First published
05 apr 2023

J. Mater. Chem. B, 2023,11, 4005-4013

Inflammation-targeting polyamine nanomedicines for the treatment of ulcerative colitis

A. Nishiguchi and T. Taguchi, J. Mater. Chem. B, 2023, 11, 4005 DOI: 10.1039/D3TB00424D

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