Issue 24, 2023

Hybrid core–shell nanoparticles for cell-specific magnetic separation and photothermal heating

Abstract

Hyperthermia, as the process of heating a malignant site above 42 °C to trigger cell death, has emerged as an effective and selective cancer therapy strategy. Various modalities of hyperthermia have been proposed, among which magnetic and photothermal hyperthermia are known to benefit from the use of nanomaterials. In this context, we introduce herein a hybrid colloidal nanostructure comprising plasmonic gold nanorods (AuNRs) covered by a silica shell, onto which iron oxide nanoparticles (IONPs) are subsequently grown. The resulting hybrid nanostructures are responsive to both external magnetic fields and near-infrared irradiation. As a result, they can be applied for the targeted magnetic separation of selected cell populations – upon targeting by antibody functionalization – as well as for photothermal heating. Through this combined functionality, the therapeutic effect of photothermal heating can be enhanced. We demonstrate both the fabrication of the hybrid system and its application for targeted photothermal hyperthermia of human glioblastoma cells.

Graphical abstract: Hybrid core–shell nanoparticles for cell-specific magnetic separation and photothermal heating

Supplementary files

Article information

Article type
Paper
Submitted
23 feb 2023
Accepted
04 apr 2023
First published
05 apr 2023

J. Mater. Chem. B, 2023,11, 5574-5585

Hybrid core–shell nanoparticles for cell-specific magnetic separation and photothermal heating

C. de la Encarnación, F. Jungwirth, D. Vila-Liarte, C. Renero-Lecuna, S. Kavak, I. Orue, C. Wilhelm, S. Bals, M. Henriksen-Lacey, D. Jimenez de Aberasturi and L. M. Liz-Marzán, J. Mater. Chem. B, 2023, 11, 5574 DOI: 10.1039/D3TB00397C

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