Issue 10, 2023

A mace-like heterostructural enriched injectable hydrogel composite for on-demand promotion of diabetic wound healing

Abstract

Wound healing is a multifaceted process that involves hemostasis, inflammation, proliferation, and remodeling stages. Diabetic wounds affect the transition of the organized phases and result in delayed healing due to impaired angiogenesis, chronic inflammation, bacterial infection, and insufficient growth factors. Multifunctional heterostructural nanoparticles enriched minimally invasive hydrogels for on-demand procedural distribution to aid wound healing at various stages has become a promising strategy. Herein, silk fibroin-hyaluronic acid based injectable hydrogels incorporated with mace-like Au–CuS heterostructural nanoparticles (gAu–CuS HSs) were used to cure diabetic wounds. SF–HA and the rough surface of gAu–CuS HSs confer a synergistic hemostatic phase with a nano-bridge effect and rapidly close the wounds. During the inflammation stage, gAu–CuS HSs perform in-space resonance energy transfer under 808 nm laser irradiation which in return produces reactive oxygen species for bacterial destruction. The unusual mace-like rough structure of nanoparticles causes macrophage transfer to the M2 phenotype, regulates cytokine expression (interleukin 6, transforming factor-β1, interferon γ, and interleukin-10), promotes angiogenesis, and promotes cell multiplication and fibroblast emigration to the wound area during the proliferation and remodeling phase. Overall, the gAu–CuS HSs reinforced injectable hydrogel programmatically accelerates wound healing and could represent a versatile strategy for advanced diabetic wound healing.

Graphical abstract: A mace-like heterostructural enriched injectable hydrogel composite for on-demand promotion of diabetic wound healing

Supplementary files

Article information

Article type
Paper
Submitted
03 nov 2022
Accepted
24 jan 2023
First published
25 jan 2023
This article is Open Access
Creative Commons BY-NC license

J. Mater. Chem. B, 2023,11, 2166-2183

A mace-like heterostructural enriched injectable hydrogel composite for on-demand promotion of diabetic wound healing

L. Wang, Z. Hussain, P. Zheng, Y. Zhang, Y. Cao, T. Gao, Z. Zhang, Y. Zhang and R. Pei, J. Mater. Chem. B, 2023, 11, 2166 DOI: 10.1039/D2TB02403A

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements