Issue 46, 2023

Recent developments for intermolecular enantioselective amination of non-acidic C(sp3)–H bonds

Abstract

Enantioenriched chiral amines are of exceptional importance in the pharmaceutical industry. Recently, several new methods for the installation of these functional groups directly from non-acidic C(sp3)–H bonds by catalytic intermolecular enantioselective amination have been reported. These methods represent significant advances of the field and most of them display high levels of enantioselectivity, utilize the C(sp3)–H substrate as the limiting reagent, feature good functional group tolerance, and show compatibility with late-stage C(sp3)–H amination of advanced substrates. This perspective provides an overview of the recent developments in this rapidly advancing field and outlines possibilities and limitations, which will help identify unsolved challenges and guide future research efforts.

Graphical abstract: Recent developments for intermolecular enantioselective amination of non-acidic C(sp3)–H bonds

Article information

Article type
Perspective
Submitted
04 sep 2023
Accepted
07 nov 2023
First published
08 nov 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2023,14, 13278-13289

Recent developments for intermolecular enantioselective amination of non-acidic C(sp3)–H bonds

H. Li, X. Chen and S. Kramer, Chem. Sci., 2023, 14, 13278 DOI: 10.1039/D3SC04643E

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