Issue 35, 2023

Responsive calcium-derived nanoassemblies induce mitochondrial disorder to promote tumor calcification

Abstract

Physiological calcification of the treated tumor area is considered to be a predictor of good prognosis. Promoting tumor calcification by inducing mitochondrial metabolic disorder and destroying calcium equilibrium has a potential inhibitory effect on tumor proliferation. Here, by promoting calcification by inducing mitochondrial dysfunction combined with triggering a surge of reactive oxygen species, we construct a bioresponsive calcification initiator, termed CaP-AA, using CaHPO4 covalently doped L-ascorbic acid. CaHPO4 releases Ca2+ within the cytoplasm of tumor cells to trigger calcium overload. Meanwhile, exogenous L-ascorbic acid indirectly enhances metabolic balance disruption via pro-oxidant effects. Such Ca2+ overload increases the likelihood of tumor calcification in vivo for tumor inhibition by perturbing mitochondrial homeostasis. The introduction of responsive calcium sources that would, in turn, trigger intratumoral calcification mediated by perturbing mitochondrial homeostasis would be an effective regulatory strategy for tumor therapy.

Graphical abstract: Responsive calcium-derived nanoassemblies induce mitochondrial disorder to promote tumor calcification

Supplementary files

Article information

Article type
Edge Article
Submitted
08 jun 2023
Accepted
14 aug 2023
First published
23 aug 2023
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2023,14, 9350-9359

Responsive calcium-derived nanoassemblies induce mitochondrial disorder to promote tumor calcification

Y. Zhao, X. Yu, W. Kong, R. Kong, E. Zhang, L. Xia, J. Zhang, F. Qu and W. Tan, Chem. Sci., 2023, 14, 9350 DOI: 10.1039/D3SC02945J

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