Issue 47, 2023

Mukaiyama aldol reaction: an effective asymmetric approach to access chiral natural products and their derivatives/analogues

Abstract

The Mukaiyama aldol reaction is generally a Lewis-acid catalyzed cross-aldol reaction between an aldehyde or ketone and silyl enol ether. It was first described by Mukaiyama in 1973, almost 5 decades ago, to achieve the enantioselective synthesis of β-hydroxy carbonyl compounds in high percentage yields. Mukaiyama aldol adducts play a pivotal role in the synthesis of various naturally occurring and medicinally important organic compounds such as polyketides, alkaloids, macrolides, etc. This review highlights the significance of the Mukaiyama aldol reaction towards the asymmetric synthesis of a wide range of biologically active natural products reported recently (since 2020).

Graphical abstract: Mukaiyama aldol reaction: an effective asymmetric approach to access chiral natural products and their derivatives/analogues

Article information

Article type
Review Article
Submitted
26 jul 2023
Accepted
21 okt 2023
First published
08 nov 2023
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2023,13, 32975-33027

Mukaiyama aldol reaction: an effective asymmetric approach to access chiral natural products and their derivatives/analogues

A. Mushtaq and A. F. Zahoor, RSC Adv., 2023, 13, 32975 DOI: 10.1039/D3RA05058K

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