Issue 23, 2023

Targeted photodynamic therapy for breast cancer: the potential of glyconanoparticles

Abstract

Photodynamic therapy (PDT) uses a non-toxic light sensitive molecule, a photosensitiser, that releases cytotoxic reactive oxygen species upon activation with light of a specific wavelength. Here, glycan-modified 16 nm gold nanoparticles (glycoAuNPs) were explored for their use in targeted PDT, where the photosensitiser was localised to the target cell through selective glycan–lectin interactions. Polyacrylamide (PAA)-glycans were chosen to assess glycan binding to the cell lines. These PAA-glycans indicated the selective uptake of a galactose-derivative PAA by two breast cancer cell lines, SK-BR-3 and MDA-MD-231. Subsequently, AuNPs were modified with a galactose-derivative ligand and an amine derivate of the photosensitiser chlorin e6 was incorporated to the nanoparticle surface via amide bond formation using EDC/NHS coupling chemistry. The dual modified nanoparticles were investigated for the targeted cell killing of breast cancer cells, demonstrating the versatility of using glycoAuNPs for selective binding to different cancer cells and their potential use for targeted PDT.

Graphical abstract: Targeted photodynamic therapy for breast cancer: the potential of glyconanoparticles

Supplementary files

Article information

Article type
Paper
Submitted
21 jul 2023
Accepted
15 okt 2023
First published
27 okt 2023
This article is Open Access
Creative Commons BY license

Nanoscale Adv., 2023,5, 6501-6513

Targeted photodynamic therapy for breast cancer: the potential of glyconanoparticles

B. A. Thomas-Moore, S. Dedola, D. A. Russell, R. A. Field and M. J. Marín, Nanoscale Adv., 2023, 5, 6501 DOI: 10.1039/D3NA00544E

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