Issue 14, 2023

Plant-derived exosomal nanoparticles: potential therapeutic for inflammatory bowel disease

Abstract

Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is a chronic autoimmune disorder characterized by inflammation. However, currently available disease-modifying anti-IBD drugs exhibit limited efficacy in IBD therapy. Furthermore, existing therapeutic approaches provide only partial relief from IBD symptoms and are associated with certain side effects. In recent years, a novel category of nanoscale membrane vesicles, known as plant-derived exosome-like nanoparticles (PDENs), has been identified in edible plants. These PDENs are abundant in bioactive lipids, proteins, microRNAs, and other pharmacologically active compounds. Notably, PDENs possess immunomodulatory, antitumor, regenerative, and anti-inflammatory properties, making them particularly promising for the treatment of intestinal diseases. Moreover, PDENs can be engineered as targeted delivery systems for the efficient transport of chemical or nucleic acid drugs to the site of intestinal inflammation. In the present study, we provided an overview of PDENs, including their biogenesis, extraction, purification, and construction strategies, and elucidated their physiological functions and therapeutic effects on IBD. Additionally, we summarized the applications and potential of PDENs in IBD treatment while highlighting the future directions and challenges in the field of emerging nanotherapeutics for IBD therapy.

Graphical abstract: Plant-derived exosomal nanoparticles: potential therapeutic for inflammatory bowel disease

Article information

Article type
Review Article
Submitted
12 feb 2023
Accepted
21 jun 2023
First published
23 jun 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2023,5, 3575-3588

Plant-derived exosomal nanoparticles: potential therapeutic for inflammatory bowel disease

D. Li, Q. Tang, M. Yang, H. Xu, M. Zhu, Y. Zhang, C. Tian, Y. Nie, J. Wang, Y. Liang, L. Wang and J. Yao, Nanoscale Adv., 2023, 5, 3575 DOI: 10.1039/D3NA00093A

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