Issue 5, 2023

Scavenging neurotoxic aldehydes using lysine carbon dots

Abstract

Reactive aldehydes generated in cells and tissues are associated with adverse physiological effects. Dihydroxyphenylacetaldehyde (DOPAL), the biogenic aldehyde enzymatically produced from dopamine, is cytotoxic, generates reactive oxygen species, and triggers aggregation of proteins such as α-synuclein implicated in Parkinson's disease. Here, we demonstrate that carbon dots (C-dots) prepared from lysine as the carbonaceous precursor bind DOPAL molecules through interactions between the aldehyde units and amine residues on the C-dot surface. A set of biophysical and in vitro experiments attests to attenuation of the adverse biological activity of DOPAL. In particular, we show that the lysine-C-dots inhibit DOPAL-induced α-synuclein oligomerization and cytotoxicity. This work underlines the potential of lysine-C-dots as an effective therapeutic vehicle for aldehyde scavenging.

Graphical abstract: Scavenging neurotoxic aldehydes using lysine carbon dots

Supplementary files

Article information

Article type
Paper
Submitted
13 nov 2022
Accepted
17 jan 2023
First published
19 jan 2023
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2023,5, 1356-1367

Scavenging neurotoxic aldehydes using lysine carbon dots

D. N. Bloch, M. Sandre, S. Ben Zichri, A. Masato, S. Kolusheva, L. Bubacco and R. Jelinek, Nanoscale Adv., 2023, 5, 1356 DOI: 10.1039/D2NA00804A

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