Issue 21, 2023

NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice

Abstract

In this study, we developed NIR-light responsive poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) by incorporating the ICG dye for the local delivery of small-molecule drugs and therapeutics. Since NIR light can penetrate the skin up to a depth of 2 mm, it allows externally controlled photothermal-induced drug release. The synthesized NPs had a size of approximately 100 nm upon conjugation with a model anticancer drug, doxorubicin (Dox), which demonstrated in vivo NIR-derived heat generation exceeding 45 °C within 5 minutes. The in vivo efficacy of these NPs was evaluated by administering them via the tail vein route in DMBA/TPA-treated mice, resulting in a significant decrease in tumor size (from 15 to 1 mm3). Histological results obtained from sacrificed tumor tissue also clearly supported the therapeutic activity of the developed NPs. This study indicates that NIR-guided PLGA-based NPs allow the localized delivery of therapeutics in a spatially controlled manner, potentially improving overall patient care.

Graphical abstract: NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice

Supplementary files

Article information

Article type
Paper
Submitted
07 jul 2023
Accepted
18 sep 2023
First published
20 sep 2023
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2023,4, 5175-5183

NIR-light-triggered delivery of doxorubicin-loaded PLGA nanoparticles for synergistic cancer therapy on DMBA/TPA induced tumor-bearing mice

T. Z. Khan, S. M. Newaj, A. Rahman, R. Tabassum, K. N. Tasnim, H. M. Reza, Md. S. Reza, S. Hong and S. Md. Sharker, Mater. Adv., 2023, 4, 5175 DOI: 10.1039/D3MA00375B

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