Issue 5, 2023

Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices

Abstract

Recent years have seen continued expansion of the functionality of lab on a chip (LOC) devices. Indeed LOCs now provide scientists and developers with useful and versatile platforms across a myriad of chemical and biological applications. The field still fails, however, to integrate an often important element of bench-top analytics: real-time molecular measurements that can be used to “guide” a chemical response. Here we describe the analytical techniques that could provide LOCs with such real-time molecular monitoring capabilities. It appears to us that, among the approaches that are general (i.e., that are independent of the reactive or optical properties of their targets), sensing strategies relying on binding–induced conformational change of bioreceptors are most likely to succeed in such applications.

Graphical abstract: Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices

Article information

Article type
Perspective
Submitted
01 aug 2022
Accepted
07 nov 2022
First published
19 jan 2023

Lab Chip, 2023,23, 1339-1348

Author version available

Conformational-switch biosensors as novel tools to support continuous, real-time molecular monitoring in lab-on-a-chip devices

C. Parolo, A. Idili, J. Heikenfeld and K. W. Plaxco, Lab Chip, 2023, 23, 1339 DOI: 10.1039/D2LC00716A

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