Issue 18, 2023

Synthesis of α-cyanato-α′-carbonyl sulfoxonium ylides in water

Abstract

A new strategy for direct access to unreported α-cyanato-α′-carbonyl sulfoxonium ylides is reported. The developed open-flask operation is a catalyst-, metal- and additive-free green process, which has good compatibility with various substituents and generally excellent yields. This protocol can be applied to gram-scale production and modification of bioactive drugs which demonstrate the practicality of this method.

Graphical abstract: Synthesis of α-cyanato-α′-carbonyl sulfoxonium ylides in water

Supplementary files

Article information

Article type
Communication
Submitted
22 jul 2023
Accepted
30 aug 2023
First published
31 aug 2023

Green Chem., 2023,25, 7068-7072

Synthesis of α-cyanato-α′-carbonyl sulfoxonium ylides in water

Q. Zhang, C. Luo, R. Lai, Z. Lin, P. Jia, S. Xu, L. Guo and Y. Wu, Green Chem., 2023, 25, 7068 DOI: 10.1039/D3GC02683C

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