Issue 88, 2023

High-order framework nucleic acid for targeted-delivery of antisense peptide nucleic acids to overcome drug resistance

Abstract

A sophisticated high-order framework nucleic acid (FNA) was engineered for the targeted delivery and responsive release of environment tolerant antisense peptide nucleic acids (asPNAs). The dendritic FNA-asPNAs system was constructed via simple one-pot modular assembly and demonstrated a good synergistic effect with chemotherapy on drug resistant cancer cells.

Graphical abstract: High-order framework nucleic acid for targeted-delivery of antisense peptide nucleic acids to overcome drug resistance

Supplementary files

Article information

Article type
Communication
Submitted
31 aug 2023
Accepted
12 okt 2023
First published
13 okt 2023
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2023,59, 13223-13226

High-order framework nucleic acid for targeted-delivery of antisense peptide nucleic acids to overcome drug resistance

S. Xing, X. Lan, J. Zhang, M. Li and B. Wang, Chem. Commun., 2023, 59, 13223 DOI: 10.1039/D3CC04298G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements