Issue 63, 2023

Amyloid peptide hydrogels via formation of coordination polymers with Ag+ by its core peptide equipped with a C-cysteine

Abstract

We report that the core sequence of amyloid β (Aβ) peptide, KLVFF, when equipped with a C-terminal cysteine residue, exhibited an extremely low minimum hydrogelation concentration of 0.05 wt% in the presence of Ag+ in pH 5 buffer, with this concentration 2 orders of magnitude lower than that of the pentapeptide itself. The CD signal of the Ag+-L-KLVFFC hydrogel was observed to be sensitive to the early-stage aggregation of amyloid β peptide.

Graphical abstract: Amyloid peptide hydrogels via formation of coordination polymers with Ag+ by its core peptide equipped with a C-cysteine

Supplementary files

Article information

Article type
Communication
Submitted
28 apr 2023
Accepted
10 jul 2023
First published
10 jul 2023

Chem. Commun., 2023,59, 9599-9602

Amyloid peptide hydrogels via formation of coordination polymers with Ag+ by its core peptide equipped with a C-cysteine

Q. Wang, F. Zhou, D. Tao, J. Wei, R. Cai and Y. Jiang, Chem. Commun., 2023, 59, 9599 DOI: 10.1039/D3CC02076B

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