Issue 36, 2023

Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation

Abstract

Methyltransferases provide excellent specificity in late-stage alkylation of biomolecules. Their dependence on S-adenosyl-L-methionine (SAM) mandates efficient access to SAM analogues for biocatalytic applications. We directly compared halide methyltransferase (HMT) and methionine adenosyltransferase (MAT) to access SAM analogues and explored their utility in cascade reactions with NovO for regioselective, late-stage Friedel-Crafts alkylation of a coumarin. The HMT cascade efficiently provided SAM for methylation, while the MAT cascade also supplied high levels of SAM analogues for alkylation reactions.

Graphical abstract: Comparative S-adenosyl-l-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation

Supplementary files

Article information

Article type
Communication
Submitted
01 mar 2023
Accepted
13 apr 2023
First published
13 apr 2023

Chem. Commun., 2023,59, 5463-5466

Comparative S-adenosyl-L-methionine analogue generation for selective biocatalytic Friedel-Crafts alkylation

A. Hoffmann, K. H. Schülke, S. C. Hammer, A. Rentmeister and N. V. Cornelissen, Chem. Commun., 2023, 59, 5463 DOI: 10.1039/D3CC01036H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements