Issue 14, 2023

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticles in vivo

Abstract

Lipid-based nanoparticles have made a breakthrough in clinical disease as delivery systems due to their biocompatibility, thermal and long-term stability, high loading ability, simplicity of preparation, inexpensive production costs, and scalable manufacturing production. In particular, during the COVID-19 pandemic, this delivery system served as a vital vaccine component for virus confrontation. To obtain effective drug delivery, lipid-based nanoparticles should reach the desired sites with high efficiency, enter target cells, and release drugs. The structures and compositions of lipid-based nanoparticles can be modified to regulate these behaviors in vivo to enhance the therapeutic effects. Herein, we briefly review the development of lipid-based nanoparticles, from simple self-assembled nanovesicle-structured liposomes to multifunctional lipid nanoparticles. Subsequently, we summarize the strategies that regulate their tissue distribution, cell internalization, and drug release, highlighting the importance of the structural and componential design. We conclude with insights for further research to advance lipid-based nanotechnology.

Graphical abstract: Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticles in vivo

Article information

Article type
Review Article
Submitted
04 mar 2023
Accepted
14 mai 2023
First published
15 mai 2023

Biomater. Sci., 2023,11, 4774-4788

Structural and componential design: new strategies regulating the behavior of lipid-based nanoparticles in vivo

Q. Zhong, C. Zheng, K. Yi, R. L. Mintz, S. Lv, Y. Tao and M. Li, Biomater. Sci., 2023, 11, 4774 DOI: 10.1039/D3BM00387F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements