Issue 28, 2023

Serum metabolomic analysis revealed potential metabolite biomarkers for diabetes mellitus with coronary heart disease

Abstract

Diabetes, including its predominant form, type 2 diabetes mellitus (T2DM), has a distinctive correlation with coronary heart disease (CHD). Patients with diabetes have shown statistically higher potential risk of developing CHD complications than those without diabetes. In this study, we have conducted a metabolomic analysis of serum samples from healthy controls as well as patients with T2DM or both T2DM and CHD (CHD–T2DM). Statistical analysis of the metabolomic data revealed 611 and 420 significantly altered metabolic signatures in T2DM and CHD–T2DM patients, respectively, when compared to the healthy controls. Meanwhile, 653 metabolic features were significantly different between the CHD–T2DM and T2DM groups. Some of the metabolites at significantly different levels were identified and may serve as potential biomarkers for T2DM or CHD–T2DM. We selected three candidates, phosphocreatine (PCr), cyclic guanosine monophosphate (cGMP) and taurine for further validation among independent T2DM, CHD–T2DM and healthy control populations. These three metabolites were found to be significantly elevated in the CHD–T2DM group when compared to both T2DM and healthy control groups by the metabolomic analysis. Our results indicated that both PCr and cGMP but not taurine were successfully validated and may serve as predictive biomarkers of CHD in patients with T2DM.

Graphical abstract: Serum metabolomic analysis revealed potential metabolite biomarkers for diabetes mellitus with coronary heart disease

Article information

Article type
Paper
Submitted
16 mai 2023
Accepted
30 jun 2023
First published
03 jul 2023

Anal. Methods, 2023,15, 3432-3438

Serum metabolomic analysis revealed potential metabolite biomarkers for diabetes mellitus with coronary heart disease

Z. Jin, W. Hu and Y. Yang, Anal. Methods, 2023, 15, 3432 DOI: 10.1039/D3AY00778B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements