Issue 17, 2023

The importance of and difficulties involved in creating molecular probes for a carbon monoxide gasotransmitter

Abstract

As one of the triumvirate of recognized gasotransmitter molecules, namely NO, H2S, and CO, the physiological effects of CO and its potential as a biomarker have been widely investigated, garnering particular attention due to its reported hypotensive, anti-inflammatory, and cytoprotective properties, making it a promising therapeutic agent. However, the development of CO molecular probes has remained relatively stagnant in comparison with the fluorescent probes for NO and H2S, owing to its inert molecular state under physiological conditions. In this review, starting from elucidating the definition and significance of CO as a gasotransmitter, the imperative for the advancement of CO probes, especially fluorescent probes, is expounded. Subsequently, the current state of development of CO probe methodologies is comprehensively reviewed, with an overview of the challenges and prospects in this burgeoning field of research.

Graphical abstract: The importance of and difficulties involved in creating molecular probes for a carbon monoxide gasotransmitter

Article information

Article type
Critical Review
Submitted
27 mai 2023
Accepted
10 jul 2023
First published
11 jul 2023

Analyst, 2023,148, 3952-3970

The importance of and difficulties involved in creating molecular probes for a carbon monoxide gasotransmitter

H. Liu, T. Liu, Q. Qin, B. Li, F. Li, B. Zhang and W. Sun, Analyst, 2023, 148, 3952 DOI: 10.1039/D3AN00849E

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