Issue 48, 2022

Spatiotemporal control over 3D protein nanocage superlattices for the hierarchical encapsulation and release of different cargo molecules

Abstract

Taking inspiration from Nature, we have constructed a two-compartment system based on 3D ferritin nanocage superlattices, the self-assembly behavior of which can be spatiotemporally controlled using two designed switches. One pH switch regulates the assembly of the ferritin subunit into its shell-like structure, whereas the other metal switch is responsible for assembly of the 3D superlattices from ferritin nanocages as building blocks. Consequently, this system holds great promise for the hierarchical encapsulation and release of two different cargo molecules.

Graphical abstract: Spatiotemporal control over 3D protein nanocage superlattices for the hierarchical encapsulation and release of different cargo molecules

Supplementary files

Article information

Article type
Communication
Submitted
13 sep 2022
Accepted
25 nov 2022
First published
25 nov 2022

J. Mater. Chem. B, 2022,10, 9968-9973

Spatiotemporal control over 3D protein nanocage superlattices for the hierarchical encapsulation and release of different cargo molecules

X. Zhang, R. Zeng, T. Zhang, C. Lv, J. Zang and G. Zhao, J. Mater. Chem. B, 2022, 10, 9968 DOI: 10.1039/D2TB01961B

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